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Article: A Compass at Weak Magnetic Fields Using Thymine Dimer Repair

TitleA Compass at Weak Magnetic Fields Using Thymine Dimer Repair
Authors
Issue Date2018
Citation
ACS Central Science, 2018, v. 4, n. 3, p. 405-412 How to Cite?
AbstractHow birds sense the variations in Earth's magnetic field for navigation is poorly understood, although cryptochromes, proteins homologous to photolyases, have been proposed to participate in this magnetic sensing. Here, in electrochemical studies with an applied magnetic field, we monitor the repair of cyclobutane pyrimidine dimer lesions in duplex DNA by photolyase, mutants of photolyase, and a modified cryptochrome. We find that the yield of dimer repair is dependent on the strength and angle of the applied magnetic field even when using magnetic fields weaker than 1 gauss. This high sensitivity to weak magnetic fields depends upon a fast radical pair reaction on the thymines leading to repair. These data illustrate chemically how cyclobutane pyrimidine dimer repair may be used in a biological compass informed by variations in Earth's magnetic field.
Persistent Identifierhttp://hdl.handle.net/10722/262786
ISSN
2019 Impact Factor: 12.685
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZwang, TJ-
dc.contributor.authorTse, ECM-
dc.contributor.authorZhong, D-
dc.contributor.authorBarton, JK-
dc.date.accessioned2018-10-08T02:47:02Z-
dc.date.available2018-10-08T02:47:02Z-
dc.date.issued2018-
dc.identifier.citationACS Central Science, 2018, v. 4, n. 3, p. 405-412-
dc.identifier.issn2374-7943-
dc.identifier.urihttp://hdl.handle.net/10722/262786-
dc.description.abstractHow birds sense the variations in Earth's magnetic field for navigation is poorly understood, although cryptochromes, proteins homologous to photolyases, have been proposed to participate in this magnetic sensing. Here, in electrochemical studies with an applied magnetic field, we monitor the repair of cyclobutane pyrimidine dimer lesions in duplex DNA by photolyase, mutants of photolyase, and a modified cryptochrome. We find that the yield of dimer repair is dependent on the strength and angle of the applied magnetic field even when using magnetic fields weaker than 1 gauss. This high sensitivity to weak magnetic fields depends upon a fast radical pair reaction on the thymines leading to repair. These data illustrate chemically how cyclobutane pyrimidine dimer repair may be used in a biological compass informed by variations in Earth's magnetic field.-
dc.languageeng-
dc.relation.ispartofACS Central Science-
dc.titleA Compass at Weak Magnetic Fields Using Thymine Dimer Repair-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acscentsci.8b00008-
dc.identifier.scopuseid_2-s2.0-85044780250-
dc.identifier.hkuros293827-
dc.identifier.volume4-
dc.identifier.issue3-
dc.identifier.spage405-
dc.identifier.epage412-
dc.identifier.eissn2374-7951-
dc.identifier.isiWOS:000428801200016-

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