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Article: Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations

TitleBrij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations
Authors
KeywordsChitosan
Brij-S20
Solubility
P-Glycoprotein
Drug efflux
Issue Date2019
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/carbpol
Citation
Carbohydrate Polymers, 2019, v. 204, p. 89-96 How to Cite?
AbstractChitosan (CS), a nature-derived polysaccharide, is a promising nano-carrier material with good biocompatibility and biodegradability. However, the biomedical applications of CS are hindered because of its poor aqueous solubility. To circumvent this drawback, a series of Brij-grafted-chitosan copolymers (BCs) with various grafting degree of Brij-S20 were first developed and reported. The results indicated that the water solubility of BCs (from 9.13 to 9.54 mg/mL) were much higher than that of CS (0.32 mg/mL), due to the broken intra- and/or inter-molecular hydrogen bonds and the decreased initial crystallinity in BCs. The amphiphilic structure of BCs presented lower critical micelle concentration (0.116–0.376 mg/mL) thus facilitating its self-aggregation into micelles for drug encapsulation. Moreover, BCs markedly enhanced the intracellular uptake of rhodamine-123 in MDCK-MDR1 cells. This inhibition on Pgp-mediated efflux was also confirmed by confocal microscopy. In conclusion, BCs could be further developed as polymeric nano-carriers for those drugs with Pgp-mediated efflux.
Persistent Identifierhttp://hdl.handle.net/10722/265093
ISSN
2017 Impact Factor: 5.158
2015 SCImago Journal Rankings: 1.490
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXiong, W-
dc.contributor.authorZhao, GD-
dc.contributor.authorYin, X-
dc.contributor.authorLinghu, KG-
dc.contributor.authorChu, MT-
dc.contributor.authorWong, GTC-
dc.contributor.authorLi, H-
dc.contributor.authorYu, H-
dc.contributor.authorWang, YT-
dc.date.accessioned2018-11-20T02:00:00Z-
dc.date.available2018-11-20T02:00:00Z-
dc.date.issued2019-
dc.identifier.citationCarbohydrate Polymers, 2019, v. 204, p. 89-96-
dc.identifier.issn0144-8617-
dc.identifier.urihttp://hdl.handle.net/10722/265093-
dc.description.abstractChitosan (CS), a nature-derived polysaccharide, is a promising nano-carrier material with good biocompatibility and biodegradability. However, the biomedical applications of CS are hindered because of its poor aqueous solubility. To circumvent this drawback, a series of Brij-grafted-chitosan copolymers (BCs) with various grafting degree of Brij-S20 were first developed and reported. The results indicated that the water solubility of BCs (from 9.13 to 9.54 mg/mL) were much higher than that of CS (0.32 mg/mL), due to the broken intra- and/or inter-molecular hydrogen bonds and the decreased initial crystallinity in BCs. The amphiphilic structure of BCs presented lower critical micelle concentration (0.116–0.376 mg/mL) thus facilitating its self-aggregation into micelles for drug encapsulation. Moreover, BCs markedly enhanced the intracellular uptake of rhodamine-123 in MDCK-MDR1 cells. This inhibition on Pgp-mediated efflux was also confirmed by confocal microscopy. In conclusion, BCs could be further developed as polymeric nano-carriers for those drugs with Pgp-mediated efflux.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/carbpol-
dc.relation.ispartofCarbohydrate Polymers-
dc.subjectChitosan-
dc.subjectBrij-S20-
dc.subjectSolubility-
dc.subjectP-Glycoprotein-
dc.subjectDrug efflux-
dc.titleBrij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations-
dc.typeArticle-
dc.identifier.emailChu, MT: jmtchu@hku.hk-
dc.identifier.emailWong, GTC: gordon@hku.hk-
dc.identifier.authorityWong, GTC=rp00523-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.carbpol.2018.10.007-
dc.identifier.pmid30366546-
dc.identifier.scopuseid_2-s2.0-85054449842-
dc.identifier.hkuros295861-
dc.identifier.volume204-
dc.identifier.spage89-
dc.identifier.epage96-
dc.identifier.isiWOS:000448147100011-
dc.publisher.placeUnited Kingdom-

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