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Article: 3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium

Title3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium
Authors
Issue Date2014
Citation
Nature Communications, 2014, v. 5, article no. 3329 (2014) How to Cite?
AbstractMeans for high-density multiparametric physiological mapping and stimulation are critically important in both basic and clinical cardiology. Current conformal electronic systems are essentially 2D sheets, which cannot cover the full epicardial surface or maintain reliable contact for chronic use without sutures or adhesives. Here we create 3D elastic membranes shaped precisely to match the epicardium of the heart via the use of 3D printing, as a platform for deformable arrays of multifunctional sensors, electronic and optoelectronic components. Such integumentary devices completely envelop the heart, in a form-fitting manner, and possess inherent elasticity, providing a mechanically stable biotic/abiotic interface during normal cardiac cycles. Component examples range from actuators for electrical, thermal and optical stimulation, to sensors for pH, temperature and mechanical strain. The semiconductor materials include silicon, gallium arsenide and gallium nitride, co-integrated with metals, metal oxides and polymers, to provide these and other operational capabilities. Ex vivo physiological experiments demonstrate various functions and methodological possibilities for cardiac research and therapy. © 2014 Macmillan Publishers Limited. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/265666
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXu, Lizhi-
dc.contributor.authorGutbrod, Sarah R.-
dc.contributor.authorBonifas, Andrew P.-
dc.contributor.authorSu, Yewang-
dc.contributor.authorSulkin, Matthew S.-
dc.contributor.authorLu, Nanshu-
dc.contributor.authorChung, Hyun Joong-
dc.contributor.authorJang, Kyung In-
dc.contributor.authorLiu, Zhuangjian-
dc.contributor.authorYing, Ming-
dc.contributor.authorLu, Chi-
dc.contributor.authorWebb, R. Chad-
dc.contributor.authorKim, Jong Seon-
dc.contributor.authorLaughner, Jacob I.-
dc.contributor.authorCheng, Huanyu-
dc.contributor.authorLiu, Yuhao-
dc.contributor.authorAmeen, Abid-
dc.contributor.authorJeong, Jae Woong-
dc.contributor.authorKim, Gwang Tae-
dc.contributor.authorHuang, Yonggang-
dc.contributor.authorEfimov, Igor R.-
dc.contributor.authorRogers, John A.-
dc.date.accessioned2018-12-03T01:21:19Z-
dc.date.available2018-12-03T01:21:19Z-
dc.date.issued2014-
dc.identifier.citationNature Communications, 2014, v. 5, article no. 3329 (2014)-
dc.identifier.urihttp://hdl.handle.net/10722/265666-
dc.description.abstractMeans for high-density multiparametric physiological mapping and stimulation are critically important in both basic and clinical cardiology. Current conformal electronic systems are essentially 2D sheets, which cannot cover the full epicardial surface or maintain reliable contact for chronic use without sutures or adhesives. Here we create 3D elastic membranes shaped precisely to match the epicardium of the heart via the use of 3D printing, as a platform for deformable arrays of multifunctional sensors, electronic and optoelectronic components. Such integumentary devices completely envelop the heart, in a form-fitting manner, and possess inherent elasticity, providing a mechanically stable biotic/abiotic interface during normal cardiac cycles. Component examples range from actuators for electrical, thermal and optical stimulation, to sensors for pH, temperature and mechanical strain. The semiconductor materials include silicon, gallium arsenide and gallium nitride, co-integrated with metals, metal oxides and polymers, to provide these and other operational capabilities. Ex vivo physiological experiments demonstrate various functions and methodological possibilities for cardiac research and therapy. © 2014 Macmillan Publishers Limited. All rights reserved.-
dc.languageeng-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.title3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/ncomms4329-
dc.identifier.pmid24569383-
dc.identifier.scopuseid_2-s2.0-84896690454-
dc.identifier.volume5-
dc.identifier.spagearticle no. 3329 (2014)-
dc.identifier.epagearticle no. 3329 (2014)-
dc.identifier.eissn2041-1723-
dc.identifier.isiWOS:000332668300022-

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