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Conference Paper: Is preoperative staging reliable for low risk prostate cancer?

TitleIs preoperative staging reliable for low risk prostate cancer?
Authors
Issue Date2019
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.bjui.org/
Citation
The 23rd Hong Kong Urological Assoication Annual Scientific Meeting, Hong Kong, 4 November 2018. In BJU International, v. 123 n. S1, p. 7 How to Cite?
AbstractObjective: To identify the risk factors of upgrading in patients with low risk prostate cancer who underwent radical prostatectomy. Patients and Methods: All eligible patients underwent RaLRP between January 2007 to December 2017 with, 1) low risk prostate cancer according to D'Amico risk stratification identified on diagnostic non‐targeted TRUS biopsy and 2) multiparametric MRI staging <= 2. Associated factors of upgrading were analysed using linear regression analysis. Results: 99 patients were identified as low risk cancer. In final histopathology, the rate of upgrading in Gleason score and upstaging in T stage was 40.2% and 61.7%. The preoperative PSA density was significant higher in the upgraded group (p = 0.049, OR 28.2, 95% CI 1.02 – 783), with an optimal cutoff at 0.102 ng/mL2 (sensitivity 97.3%, specificity 19.3%). Preoperative PSA, MRI T stage, PIRADS grading and digital rectal exam finding did not show a significant correlation (p = 0.223, p = 0.096, p = 0.428 and p = 0.889 respectively). Conclusion: The correct risk stratification with non‐targeted TRUS biopsy is poor with a high incidence of upgrading on final histopathology. Therefore, for patients who would like to consider active surveillance, a confirmation biopsy with transperineal systematic ± targeted biopsy should be considered.
DescriptionOral Presentation
Persistent Identifierhttp://hdl.handle.net/10722/266480
ISSN
2017 Impact Factor: 4.688
2015 SCImago Journal Rankings: 2.009

 

DC FieldValueLanguage
dc.contributor.authorWong, TTF-
dc.contributor.authorTsang, CF-
dc.contributor.authorLam, PW-
dc.contributor.authorWong, KWC-
dc.contributor.authorLai, TCT-
dc.contributor.authorHo, SHB-
dc.contributor.authorNg, ATL-
dc.contributor.authorMa, WK-
dc.contributor.authorTsu, HLJ-
dc.date.accessioned2019-01-18T08:20:30Z-
dc.date.available2019-01-18T08:20:30Z-
dc.date.issued2019-
dc.identifier.citationThe 23rd Hong Kong Urological Assoication Annual Scientific Meeting, Hong Kong, 4 November 2018. In BJU International, v. 123 n. S1, p. 7-
dc.identifier.issn1464-4096-
dc.identifier.urihttp://hdl.handle.net/10722/266480-
dc.descriptionOral Presentation-
dc.description.abstractObjective: To identify the risk factors of upgrading in patients with low risk prostate cancer who underwent radical prostatectomy. Patients and Methods: All eligible patients underwent RaLRP between January 2007 to December 2017 with, 1) low risk prostate cancer according to D'Amico risk stratification identified on diagnostic non‐targeted TRUS biopsy and 2) multiparametric MRI staging <= 2. Associated factors of upgrading were analysed using linear regression analysis. Results: 99 patients were identified as low risk cancer. In final histopathology, the rate of upgrading in Gleason score and upstaging in T stage was 40.2% and 61.7%. The preoperative PSA density was significant higher in the upgraded group (p = 0.049, OR 28.2, 95% CI 1.02 – 783), with an optimal cutoff at 0.102 ng/mL2 (sensitivity 97.3%, specificity 19.3%). Preoperative PSA, MRI T stage, PIRADS grading and digital rectal exam finding did not show a significant correlation (p = 0.223, p = 0.096, p = 0.428 and p = 0.889 respectively). Conclusion: The correct risk stratification with non‐targeted TRUS biopsy is poor with a high incidence of upgrading on final histopathology. Therefore, for patients who would like to consider active surveillance, a confirmation biopsy with transperineal systematic ± targeted biopsy should be considered.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.bjui.org/-
dc.relation.ispartofBJU International-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.titleIs preoperative staging reliable for low risk prostate cancer?-
dc.typeConference_Paper-
dc.identifier.emailLam, PW: lamwayne@hku.hk-
dc.identifier.emailWong, KWC: kwwongab@HKUCC-COM.hku.hk-
dc.identifier.emailHo, SHB: hobrian@hku.hk-
dc.identifier.emailNg, ATL: ada5022@hku.hk-
dc.identifier.emailMa, WK: mwk054@hku.hk-
dc.identifier.emailTsu, HLJ: jamestsu@hku.hk-
dc.identifier.authorityLam, PW=rp02305-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/bju.14677-
dc.identifier.hkuros296737-
dc.identifier.volume123-
dc.identifier.issueS1-
dc.identifier.spage7-
dc.identifier.epage7-
dc.publisher.placeUnited Kingdom-

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