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Article: Clinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China

TitleClinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China
Authors
KeywordsAntifungal susceptibilities
Molecular epidemiology
Rapid identification
Talaromyces marneffei
Talaromycosis
Issue Date2019
PublisherWiley-Blackwell Verlag GmbH. The Journal's web site is located at http://www.blackwellpublishing.com/journals/MYC
Citation
Mycoses: diagnosis, therapy and prophylaxis of fungal diseases, 2019, v. 62 n. 5, p. 450-457 How to Cite?
AbstractAlthough case series of talaromycosis have been reported in China, their detailed clinical and microbiological characteristics have never been systematically profiled. In this study, we report the clinical characteristics, molecular epidemiology, rapid identification and antifungal susceptibilities of talaromycosis in The University of Hong Kong‐Shenzhen Hospital in Shenzhen. Seven cases of talaromycosis were observed since commencement of hospital service in 2012. Three patients were local Shenzhen residents, whereas the other four were immigrants from other parts of China. Two patients were HIV‐negative, but with underlying diseases requiring immunosuppressive therapy. Two of the seven patients succumbed. All the seven isolates were successfully identified as T. marneffei by MALDI–TOF MS using Bruker database expanded with in‐house generated T. marneffei mass spectra. MLST showed that the seven strains belonged to six different, novel sequences types. Phylogenetic analyses of the concatenated five‐locus sequence revealed that the seven strains were scattered amongst other T. marneffei strains. The MICs of itraconazole, isavuconazole, posaconazole and voriconazole against the seven clinical isolates were low but MICs of anidulafungin were high. Underlying diseases other than HIV infection are increasingly important risk factors of talaromycosis. MALDI–TOF MS is useful for rapid identification. Highly diverse T. marneffei sequence types were observed.
Persistent Identifierhttp://hdl.handle.net/10722/266504
ISSN
2017 Impact Factor: 2.793
2015 SCImago Journal Rankings: 0.921
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, SKP-
dc.contributor.authorXing, F-
dc.contributor.authorTsang, CC-
dc.contributor.authorTang, JYM-
dc.contributor.authorTan, YP-
dc.contributor.authorYe, H-
dc.contributor.authorLau, RWT-
dc.contributor.authorChen, JHK-
dc.contributor.authorLo, SKF-
dc.contributor.authorWoo, PCY-
dc.date.accessioned2019-01-18T08:20:58Z-
dc.date.available2019-01-18T08:20:58Z-
dc.date.issued2019-
dc.identifier.citationMycoses: diagnosis, therapy and prophylaxis of fungal diseases, 2019, v. 62 n. 5, p. 450-457-
dc.identifier.issn0933-7407-
dc.identifier.urihttp://hdl.handle.net/10722/266504-
dc.description.abstractAlthough case series of talaromycosis have been reported in China, their detailed clinical and microbiological characteristics have never been systematically profiled. In this study, we report the clinical characteristics, molecular epidemiology, rapid identification and antifungal susceptibilities of talaromycosis in The University of Hong Kong‐Shenzhen Hospital in Shenzhen. Seven cases of talaromycosis were observed since commencement of hospital service in 2012. Three patients were local Shenzhen residents, whereas the other four were immigrants from other parts of China. Two patients were HIV‐negative, but with underlying diseases requiring immunosuppressive therapy. Two of the seven patients succumbed. All the seven isolates were successfully identified as T. marneffei by MALDI–TOF MS using Bruker database expanded with in‐house generated T. marneffei mass spectra. MLST showed that the seven strains belonged to six different, novel sequences types. Phylogenetic analyses of the concatenated five‐locus sequence revealed that the seven strains were scattered amongst other T. marneffei strains. The MICs of itraconazole, isavuconazole, posaconazole and voriconazole against the seven clinical isolates were low but MICs of anidulafungin were high. Underlying diseases other than HIV infection are increasingly important risk factors of talaromycosis. MALDI–TOF MS is useful for rapid identification. Highly diverse T. marneffei sequence types were observed.-
dc.languageeng-
dc.publisherWiley-Blackwell Verlag GmbH. The Journal's web site is located at http://www.blackwellpublishing.com/journals/MYC-
dc.relation.ispartofMycoses: diagnosis, therapy and prophylaxis of fungal diseases-
dc.subjectAntifungal susceptibilities-
dc.subjectMolecular epidemiology-
dc.subjectRapid identification-
dc.subjectTalaromyces marneffei-
dc.subjectTalaromycosis-
dc.titleClinical characteristics, rapid identification, molecular epidemiology and antifungal susceptibilities of Talaromyces marneffei infections in Shenzhen, China-
dc.typeArticle-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.emailTsang, CC: cchtsang@hku.hk-
dc.identifier.emailTan, YP: edditan@hku.hk-
dc.identifier.emailChen, JHK: jonchk@hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.authorityLau, SKP=rp00486-
dc.identifier.authorityTsang, CC=rp02492-
dc.identifier.authorityWoo, PCY=rp00430-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/myc.12887-
dc.identifier.pmid30597630-
dc.identifier.scopuseid_2-s2.0-85064072974-
dc.identifier.hkuros296623-
dc.identifier.hkuros304192-
dc.identifier.volume62-
dc.identifier.issue5-
dc.identifier.spage450-
dc.identifier.epage457-
dc.identifier.isiWOS:000466392700007-
dc.publisher.placeGermany-

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