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Article: Cutaneous Angiosarcoma Secondary to Lymphoedema or Radiation Therapy — A Systematic Review
Title | Cutaneous Angiosarcoma Secondary to Lymphoedema or Radiation Therapy — A Systematic Review |
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Authors | |
Keywords | Angiosarcoma lymphoedema radiation |
Issue Date | 2019 |
Publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/clon |
Citation | Clinical Oncology, 2019, v. 31, p. 225-231 How to Cite? |
Abstract | AIMS: Secondary angiosarcoma is known to be associated with lymphoedema or radiation after cancer treatment. This systematic review aims to evaluate the clinical features and outcomes of secondary angiosarcoma commonly arising after breast cancer treatment. MATERIALS AND METHODS: A systematic review was carried out according to the PRISMA protocol. Medline, EMBASE, CINAHL and Cochrane databases were searched for English articles to April 2018 with predefined strategy. Retrieved studies were independently screened and rated for relevance. Data were extracted by two researchers. RESULTS: There were 72 secondary angiosarcomas of the limbs. Most patients (n = 68, 94.4%) had a history of lymphoedema. The median latent period was 15 years (range 3-40 years). Thirty-eight (52.8%) patients received wide excision or amputation as a treatment for the angiosarcoma, two (2.8%) patients received isolated limb perfusion and one (1.4%) patient received systemic chemotherapy. The remaining patients received palliative care/undocumented treatment. The pooled median duration to mortality was 10.5 months (range 1-144 months). Of note, obesity was documented in seven (9.7%) patients. There were 83 breast angiosarcomas; all with known breast cancer history. Thirty-one (37.3%) patients received mastectomy as breast cancer treatment. Fifty-four (65.1%) patients had a history of adjuvant radiotherapy for the primary breast cancer. The median latent period was 6 years (range 2-50 years); the median size was 40 mm (range 8-200 mm). Forty-one (49.4%) patients received wide excision, 19 (22.9%) patients received completion mastectomy and 23 (27.7%) patients have undocumented treatment for angiosarcoma. The pooled median duration to mortality was 31 months (range 6-168 months). CONCLUSION: Angiosarcoma in lympedematous upper limbs or after breast cancer irradiation remains uncommon. However, its long latency and high mortality warrant long-term vigilant surveillance. |
Persistent Identifier | http://hdl.handle.net/10722/268227 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 0.907 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Co, THM | - |
dc.contributor.author | Lee, A | - |
dc.contributor.author | Kwong, A | - |
dc.date.accessioned | 2019-03-18T04:21:16Z | - |
dc.date.available | 2019-03-18T04:21:16Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Clinical Oncology, 2019, v. 31, p. 225-231 | - |
dc.identifier.issn | 0936-6555 | - |
dc.identifier.uri | http://hdl.handle.net/10722/268227 | - |
dc.description.abstract | AIMS: Secondary angiosarcoma is known to be associated with lymphoedema or radiation after cancer treatment. This systematic review aims to evaluate the clinical features and outcomes of secondary angiosarcoma commonly arising after breast cancer treatment. MATERIALS AND METHODS: A systematic review was carried out according to the PRISMA protocol. Medline, EMBASE, CINAHL and Cochrane databases were searched for English articles to April 2018 with predefined strategy. Retrieved studies were independently screened and rated for relevance. Data were extracted by two researchers. RESULTS: There were 72 secondary angiosarcomas of the limbs. Most patients (n = 68, 94.4%) had a history of lymphoedema. The median latent period was 15 years (range 3-40 years). Thirty-eight (52.8%) patients received wide excision or amputation as a treatment for the angiosarcoma, two (2.8%) patients received isolated limb perfusion and one (1.4%) patient received systemic chemotherapy. The remaining patients received palliative care/undocumented treatment. The pooled median duration to mortality was 10.5 months (range 1-144 months). Of note, obesity was documented in seven (9.7%) patients. There were 83 breast angiosarcomas; all with known breast cancer history. Thirty-one (37.3%) patients received mastectomy as breast cancer treatment. Fifty-four (65.1%) patients had a history of adjuvant radiotherapy for the primary breast cancer. The median latent period was 6 years (range 2-50 years); the median size was 40 mm (range 8-200 mm). Forty-one (49.4%) patients received wide excision, 19 (22.9%) patients received completion mastectomy and 23 (27.7%) patients have undocumented treatment for angiosarcoma. The pooled median duration to mortality was 31 months (range 6-168 months). CONCLUSION: Angiosarcoma in lympedematous upper limbs or after breast cancer irradiation remains uncommon. However, its long latency and high mortality warrant long-term vigilant surveillance. | - |
dc.language | eng | - |
dc.publisher | WB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/clon | - |
dc.relation.ispartof | Clinical Oncology | - |
dc.subject | Angiosarcoma | - |
dc.subject | lymphoedema | - |
dc.subject | radiation | - |
dc.title | Cutaneous Angiosarcoma Secondary to Lymphoedema or Radiation Therapy — A Systematic Review | - |
dc.type | Article | - |
dc.identifier.email | Co, THM: mcth@hku.hk | - |
dc.identifier.email | Kwong, A: avakwong@hku.hk | - |
dc.identifier.authority | Co, THM=rp02101 | - |
dc.identifier.authority | Kwong, A=rp01734 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.clon.2019.01.009 | - |
dc.identifier.scopus | eid_2-s2.0-85061047999 | - |
dc.identifier.hkuros | 297104 | - |
dc.identifier.volume | 31 | - |
dc.identifier.spage | 225 | - |
dc.identifier.epage | 231 | - |
dc.identifier.isi | WOS:000459475100004 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0936-6555 | - |