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Conference Paper: Aptamers for malaria diagnosis – a transdisciplinary venture from bio to nano
Title | Aptamers for malaria diagnosis – a transdisciplinary venture from bio to nano |
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Authors | |
Issue Date | 2019 |
Citation | The Second International Workshop by the 174th Committee JSPS on Symbiosis of Biology and Nanodevices, Kyoto Japan, 29 January 2019 How to Cite? |
Abstract | Nucleic acid aptamers have many advantages relative to antibodies for the detection of molecules for sensing, diagnostics, and for nanomedicine. Here, I will present our team’s work on aptamer application for malaria diagnosis. I will start from the structural insight from the X-ray crystal structure of the aptamer in complex with its malaria protein biomarker target Plasmodium falciparum lactate dehydrogenase. I will go on to how the aptamer was integrated into a wide range of diagnostic tests incorporating unusual technologies to enable simple color-based detection. We will discuss how other innovative chemistries within DNA aptamers can allow for very tight and also for externally controlled binding events. Finally, I will discuss our ongoing efforts for aptamer integration with nucleic acid nanostructures which can provide nanoresponse mechanisms which will be useful for a wide variety of applications in nanomedicine. We consider this juxtaposition of nucleic acid aptamers with nucleic acid nanotechnology to be a rich opportunity for diagnostics and therapeutics. |
Persistent Identifier | http://hdl.handle.net/10722/269122 |
DC Field | Value | Language |
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dc.contributor.author | Tanner, JA | - |
dc.date.accessioned | 2019-04-12T09:22:02Z | - |
dc.date.available | 2019-04-12T09:22:02Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | The Second International Workshop by the 174th Committee JSPS on Symbiosis of Biology and Nanodevices, Kyoto Japan, 29 January 2019 | - |
dc.identifier.uri | http://hdl.handle.net/10722/269122 | - |
dc.description.abstract | Nucleic acid aptamers have many advantages relative to antibodies for the detection of molecules for sensing, diagnostics, and for nanomedicine. Here, I will present our team’s work on aptamer application for malaria diagnosis. I will start from the structural insight from the X-ray crystal structure of the aptamer in complex with its malaria protein biomarker target Plasmodium falciparum lactate dehydrogenase. I will go on to how the aptamer was integrated into a wide range of diagnostic tests incorporating unusual technologies to enable simple color-based detection. We will discuss how other innovative chemistries within DNA aptamers can allow for very tight and also for externally controlled binding events. Finally, I will discuss our ongoing efforts for aptamer integration with nucleic acid nanostructures which can provide nanoresponse mechanisms which will be useful for a wide variety of applications in nanomedicine. We consider this juxtaposition of nucleic acid aptamers with nucleic acid nanotechnology to be a rich opportunity for diagnostics and therapeutics. | - |
dc.language | eng | - |
dc.relation.ispartof | The Second International Workshop by the 174th Committee JSPS on Symbiosis of Biology and Nanodevices | - |
dc.title | Aptamers for malaria diagnosis – a transdisciplinary venture from bio to nano | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Tanner, JA: jatanner@hkucc.hku.hk | - |
dc.identifier.authority | Tanner, JA=rp00495 | - |
dc.identifier.hkuros | 296595 | - |