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Article: Clinical trials of intervertebral disc regeneration: current status and future developments

TitleClinical trials of intervertebral disc regeneration: current status and future developments
Authors
KeywordsClinical trial ;;; Small molecule
Growth factor
Intervertebral disc degeneration
Mesenchymal stromal cells
Regeneration
Issue Date2019
PublisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/264
Citation
International Orthopaedics, 2019, v. 43 n. 4, p. 1003-1010 How to Cite?
AbstractIntervertebral disc (IVD) degeneration (IDD) is considered as one of the major causes for low back pain (LBP). However, conventional surgical approaches for treating LBP do not aim to counter the degeneration. Biological interventions have been investigated with an attempt to regenerate the IVD by restoring its matrices and cell activities. This review summarizes the current clinical trials that explore the efficacy of covering cell-, growth factor-, and small molecule-based approaches. While investigations of growth factor- and small molecule-based therapies are still preliminary, intradiscal delivery of mesenchymal stromal cells has been more widely adopted and shown positive results in addressing the pain and the associated physical disability, albeit to a lower extent than observed in previous animal studies. Strategies that potentiate the endogenous disc progenitors may offer a valid alternative to the exogenous cell transplantation. Identification of the novel biologics to arrest IDD phenotype may potentiate disc repair in future. Large-scale, high-quality long-term trials should be conducted to clarify the safety and efficacy of these therapies.
Persistent Identifierhttp://hdl.handle.net/10722/269582
ISSN
2017 Impact Factor: 2.377
2015 SCImago Journal Rankings: 1.508
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSun, Y-
dc.contributor.authorLeung, VYL-
dc.contributor.authorCheung, KMC-
dc.date.accessioned2019-04-24T08:10:36Z-
dc.date.available2019-04-24T08:10:36Z-
dc.date.issued2019-
dc.identifier.citationInternational Orthopaedics, 2019, v. 43 n. 4, p. 1003-1010-
dc.identifier.issn0341-2695-
dc.identifier.urihttp://hdl.handle.net/10722/269582-
dc.description.abstractIntervertebral disc (IVD) degeneration (IDD) is considered as one of the major causes for low back pain (LBP). However, conventional surgical approaches for treating LBP do not aim to counter the degeneration. Biological interventions have been investigated with an attempt to regenerate the IVD by restoring its matrices and cell activities. This review summarizes the current clinical trials that explore the efficacy of covering cell-, growth factor-, and small molecule-based approaches. While investigations of growth factor- and small molecule-based therapies are still preliminary, intradiscal delivery of mesenchymal stromal cells has been more widely adopted and shown positive results in addressing the pain and the associated physical disability, albeit to a lower extent than observed in previous animal studies. Strategies that potentiate the endogenous disc progenitors may offer a valid alternative to the exogenous cell transplantation. Identification of the novel biologics to arrest IDD phenotype may potentiate disc repair in future. Large-scale, high-quality long-term trials should be conducted to clarify the safety and efficacy of these therapies.-
dc.languageeng-
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/264-
dc.relation.ispartofInternational Orthopaedics-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in International Orthopaedics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00264-018-4245-8-
dc.subjectClinical trial ;;; Small molecule-
dc.subjectGrowth factor-
dc.subjectIntervertebral disc degeneration-
dc.subjectMesenchymal stromal cells-
dc.subjectRegeneration-
dc.titleClinical trials of intervertebral disc regeneration: current status and future developments-
dc.typeArticle-
dc.identifier.emailSun, Y: hkusunyi@hku.hk-
dc.identifier.emailLeung, VYL: vicleung@hku.hk-
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.authorityLeung, VYL=rp01764-
dc.identifier.authorityCheung, KMC=rp00387-
dc.description.naturepostprint-
dc.identifier.doi10.1007/s00264-018-4245-8-
dc.identifier.pmid30498908-
dc.identifier.scopuseid_2-s2.0-85057602136-
dc.identifier.hkuros297453-
dc.identifier.volume43-
dc.identifier.issue4-
dc.identifier.spage1003-
dc.identifier.epage1010-
dc.identifier.isiWOS:000462975000032-
dc.publisher.placeGermany-

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