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- Publisher Website: 10.1016/j.ijmm.2019.05.003
- Scopus: eid_2-s2.0-85065777517
- PMID: 31113737
- WOS: WOS:000488890000002
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Article: Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong
Title | Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong |
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Authors | |
Keywords | Hypervirulent Clostridioides difficile Binary toxin Pathogenicity locus Trehalose repressor |
Issue Date | 2019 |
Publisher | Urban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/ijmm |
Citation | International Journal of Medical Microbiology, 2019, v. 309 n. 5, p. 270-273 How to Cite? |
Abstract | In 2017, we identified a Clostridium difficile strain HKCD4 that caused community-acquired fulminant colitis in a previously healthy child. Phylogenetically, it belonged to clade 2, sequence type 67 and was resistant to fluoroquinolone and tetracycline. The strain was pathogenicity locus and binary toxin positive. It has a mutation in the trehalose repressor treR leading to the L172I substitution that was previously reported in the epidemic ribotype 027 lineage. HKCD4 has a tcdB sequence that shared very high identities with 3 highly virulent reference strains. It has a CpG depleted genome that is characteristic of hypervirulent C. difficile. The emergence of ST67 lineage with molecular feature of hypervirulence in the community is concerning and emphasizes the need for full characterization of strains causing severe disease in patients without classical risk factors. |
Persistent Identifier | http://hdl.handle.net/10722/272000 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.196 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cao, H | - |
dc.contributor.author | Wong, SCY | - |
dc.contributor.author | Yam, WC | - |
dc.contributor.author | Liu, MCJ | - |
dc.contributor.author | Chow, KH | - |
dc.contributor.author | Wu, AKL | - |
dc.contributor.author | Ho, PL | - |
dc.date.accessioned | 2019-07-20T10:33:44Z | - |
dc.date.available | 2019-07-20T10:33:44Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | International Journal of Medical Microbiology, 2019, v. 309 n. 5, p. 270-273 | - |
dc.identifier.issn | 1438-4221 | - |
dc.identifier.uri | http://hdl.handle.net/10722/272000 | - |
dc.description.abstract | In 2017, we identified a Clostridium difficile strain HKCD4 that caused community-acquired fulminant colitis in a previously healthy child. Phylogenetically, it belonged to clade 2, sequence type 67 and was resistant to fluoroquinolone and tetracycline. The strain was pathogenicity locus and binary toxin positive. It has a mutation in the trehalose repressor treR leading to the L172I substitution that was previously reported in the epidemic ribotype 027 lineage. HKCD4 has a tcdB sequence that shared very high identities with 3 highly virulent reference strains. It has a CpG depleted genome that is characteristic of hypervirulent C. difficile. The emergence of ST67 lineage with molecular feature of hypervirulence in the community is concerning and emphasizes the need for full characterization of strains causing severe disease in patients without classical risk factors. | - |
dc.language | eng | - |
dc.publisher | Urban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/ijmm | - |
dc.relation.ispartof | International Journal of Medical Microbiology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Hypervirulent | - |
dc.subject | Clostridioides difficile | - |
dc.subject | Binary toxin | - |
dc.subject | Pathogenicity locus | - |
dc.subject | Trehalose repressor | - |
dc.title | Genomic investigation of a sequence type 67 Clostridium difficile causing community-acquired fulminant colitis in Hong Kong | - |
dc.type | Article | - |
dc.identifier.email | Cao, H: hcao@hku.hk | - |
dc.identifier.email | Wong, SCY: wcy288@HKUCC-COM.hku.hk | - |
dc.identifier.email | Yam, WC: wcyam@hku.hk | - |
dc.identifier.email | Chow, KH: khchowb@hku.hk | - |
dc.identifier.email | Wu, AKL: alanklwu@hkucc.hku.hk | - |
dc.identifier.email | Ho, PL: plho@hku.hk | - |
dc.identifier.authority | Yam, WC=rp00313 | - |
dc.identifier.authority | Chow, KH=rp00370 | - |
dc.identifier.authority | Ho, PL=rp00406 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.ijmm.2019.05.003 | - |
dc.identifier.pmid | 31113737 | - |
dc.identifier.scopus | eid_2-s2.0-85065777517 | - |
dc.identifier.hkuros | 298359 | - |
dc.identifier.volume | 309 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 270 | - |
dc.identifier.epage | 273 | - |
dc.identifier.isi | WOS:000488890000002 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 1438-4221 | - |