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- Publisher Website: 10.1073/pnas.1816833116
- Scopus: eid_2-s2.0-85063962818
- PMID: 30850520
- WOS: WOS:000462382800086
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Article: Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory
Title | Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory |
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Authors | |
Keywords | cholecystokinin NMDA receptor long-term potentiation memory entorhinal cortex |
Issue Date | 2019 |
Publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org |
Citation | Proceedings of the National Academy of Sciences, 2019, v. 116 n. 13, p. 6397-6406 How to Cite? |
Abstract | Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces LTP. CCK−/− mice lacked neocortical LTP and showed deficits in a cue–cue associative learning paradigm; and administration of CCK rescued associative learning deficits. High-frequency stimulation-induced neocortical LTP was completely blocked by either the NMDAR antagonist or the CCKBR antagonist, while application of either NMDA or CCK induced LTP after low-frequency stimulation. In the presence of CCK, LTP was still induced even after blockade of NMDARs. Local application of NMDA induced the release of CCK in the neocortex. These findings suggest that NMDARs control the release of CCK, which enables neocortical LTP and the formation of cue–cue associative memory. |
Persistent Identifier | http://hdl.handle.net/10722/272728 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | He, L | - |
dc.contributor.author | Li, X | - |
dc.contributor.author | Wonga, YT | - |
dc.contributor.author | Shum, DKY | - |
dc.contributor.author | Chan, YS | - |
dc.date.accessioned | 2019-08-06T09:15:27Z | - |
dc.date.available | 2019-08-06T09:15:27Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences, 2019, v. 116 n. 13, p. 6397-6406 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/272728 | - |
dc.description.abstract | Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces LTP. CCK−/− mice lacked neocortical LTP and showed deficits in a cue–cue associative learning paradigm; and administration of CCK rescued associative learning deficits. High-frequency stimulation-induced neocortical LTP was completely blocked by either the NMDAR antagonist or the CCKBR antagonist, while application of either NMDA or CCK induced LTP after low-frequency stimulation. In the presence of CCK, LTP was still induced even after blockade of NMDARs. Local application of NMDA induced the release of CCK in the neocortex. These findings suggest that NMDARs control the release of CCK, which enables neocortical LTP and the formation of cue–cue associative memory. | - |
dc.language | eng | - |
dc.publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences | - |
dc.rights | Proceedings of the National Academy of Sciences. Copyright © National Academy of Sciences. | - |
dc.subject | cholecystokinin | - |
dc.subject | NMDA receptor | - |
dc.subject | long-term potentiation | - |
dc.subject | memory | - |
dc.subject | entorhinal cortex | - |
dc.title | Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory | - |
dc.type | Article | - |
dc.identifier.email | Shum, DKY: shumdkhk@hkucc.hku.hk | - |
dc.identifier.email | Chan, YS: yschan@hku.hk | - |
dc.identifier.authority | Shum, DKY=rp00321 | - |
dc.identifier.authority | Chan, YS=rp00318 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.1816833116 | - |
dc.identifier.pmid | 30850520 | - |
dc.identifier.pmcid | PMC6442640 | - |
dc.identifier.scopus | eid_2-s2.0-85063962818 | - |
dc.identifier.hkuros | 300392 | - |
dc.identifier.volume | 116 | - |
dc.identifier.issue | 13 | - |
dc.identifier.spage | 6397 | - |
dc.identifier.epage | 6406 | - |
dc.identifier.isi | WOS:000462382800086 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0027-8424 | - |