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Article: Long-acting liposomal corneal anesthetics

TitleLong-acting liposomal corneal anesthetics
Authors
KeywordsLiposome
Ocular anesthesia
Tetrodotoxin
Dexmedetomidine
Concanavalin A
Issue Date2018
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2018, v. 181, p. 372-377 How to Cite?
AbstractEye drops producing long-acting ocular anesthesia would be desirable for corneal pain management. Here we present liposome-based formulations to achieve very long ocular anesthetic effect after a single eye drop instillation. The liposomes were functionalized with succinyl-Concanavalin A (sConA-Lip), which can bind corneal glycan moieties, to significantly prolong the dwell time of liposomes on the cornea. sConA-Lip were loaded with tetrodotoxin and dexmedetomidine (sConA-Lip/TD), and provided sustained release for both. A single topical instillation of sConA-Lip/TD on the cornea could achieve 105 min of complete analgesia and 608 min of partial analgesia, which was significantly longer than analgesia with proparacaine, tetrodotoxin/dexmedetomidine solution or unmodified liposomes containing tetrodotoxin and dexmedetomidine. sConA-Lip/TD were not cytotoxic in vitro to human corneal limbal epithelial cells or corneal keratocytes. Topical administration of sConA-Lip/TD provided prolonged corneal anesthesia without delaying corneal wound healing. Such a formulation may be useful for the management of acute surgical and nonsurgical corneal pain, or for treatment of other ocular surface diseases.
Persistent Identifierhttp://hdl.handle.net/10722/272787
ISSN
2017 Impact Factor: 8.806
2015 SCImago Journal Rankings: 3.565

 

DC FieldValueLanguage
dc.contributor.authorZhan, C-
dc.contributor.authorSantamaria, CM-
dc.contributor.authorWang, W-
dc.contributor.authorMcAlvin, JB-
dc.contributor.authorKohane, DS-
dc.date.accessioned2019-08-06T09:16:33Z-
dc.date.available2019-08-06T09:16:33Z-
dc.date.issued2018-
dc.identifier.citationBiomaterials, 2018, v. 181, p. 372-377-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://hdl.handle.net/10722/272787-
dc.description.abstractEye drops producing long-acting ocular anesthesia would be desirable for corneal pain management. Here we present liposome-based formulations to achieve very long ocular anesthetic effect after a single eye drop instillation. The liposomes were functionalized with succinyl-Concanavalin A (sConA-Lip), which can bind corneal glycan moieties, to significantly prolong the dwell time of liposomes on the cornea. sConA-Lip were loaded with tetrodotoxin and dexmedetomidine (sConA-Lip/TD), and provided sustained release for both. A single topical instillation of sConA-Lip/TD on the cornea could achieve 105 min of complete analgesia and 608 min of partial analgesia, which was significantly longer than analgesia with proparacaine, tetrodotoxin/dexmedetomidine solution or unmodified liposomes containing tetrodotoxin and dexmedetomidine. sConA-Lip/TD were not cytotoxic in vitro to human corneal limbal epithelial cells or corneal keratocytes. Topical administration of sConA-Lip/TD provided prolonged corneal anesthesia without delaying corneal wound healing. Such a formulation may be useful for the management of acute surgical and nonsurgical corneal pain, or for treatment of other ocular surface diseases.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials-
dc.relation.ispartofBiomaterials-
dc.subjectLiposome-
dc.subjectOcular anesthesia-
dc.subjectTetrodotoxin-
dc.subjectDexmedetomidine-
dc.subjectConcanavalin A-
dc.titleLong-acting liposomal corneal anesthetics-
dc.typeArticle-
dc.identifier.emailWang, W: wangwp@hku.hk-
dc.identifier.authorityWang, W=rp02227-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biomaterials.2018.07.054-
dc.identifier.pmid30099260-
dc.identifier.scopuseid_2-s2.0-85053163749-
dc.identifier.hkuros300379-
dc.identifier.volume181-
dc.identifier.spage372-
dc.identifier.epage377-
dc.publisher.placeNetherlands-

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