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- Publisher Website: 10.1021/acs.inorgchem.9b01199
- Scopus: eid_2-s2.0-85073643226
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Article: Metalloproteomics for unveiling the mechanism of action of metallodrugs
Title | Metalloproteomics for unveiling the mechanism of action of metallodrugs |
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Authors | |
Issue Date | 2019 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/ic |
Citation | Inorganic Chemistry, 2019, v. 58 n. 20, p. 13673-13685 How to Cite? |
Abstract | The clinical application and development of potent metal-based drugs relies heavily on a full understanding of their underlying molecular mechanisms. The emerging research field of metalloproteomics for unveiling the correlation between metals and biological proteomes has received growing attention and has been successfully implemented in medicinal inorganic chemistry. In this article, we introduce recent progress in the mechanistic studies of representative metal-based drugs by using state-of-the-art metalloproteomic approaches, with a focus on how the application of analytical chemistry, biocompatible chemical probes, and integrative omics help to advance the knowledge of metallodrug targeting profiles within a systemic perspective. |
Persistent Identifier | http://hdl.handle.net/10722/273840 |
ISSN | 2023 Impact Factor: 4.3 2023 SCImago Journal Rankings: 0.928 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Y | - |
dc.contributor.author | Li, H | - |
dc.contributor.author | Sun, H | - |
dc.date.accessioned | 2019-08-18T14:49:38Z | - |
dc.date.available | 2019-08-18T14:49:38Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Inorganic Chemistry, 2019, v. 58 n. 20, p. 13673-13685 | - |
dc.identifier.issn | 0020-1669 | - |
dc.identifier.uri | http://hdl.handle.net/10722/273840 | - |
dc.description.abstract | The clinical application and development of potent metal-based drugs relies heavily on a full understanding of their underlying molecular mechanisms. The emerging research field of metalloproteomics for unveiling the correlation between metals and biological proteomes has received growing attention and has been successfully implemented in medicinal inorganic chemistry. In this article, we introduce recent progress in the mechanistic studies of representative metal-based drugs by using state-of-the-art metalloproteomic approaches, with a focus on how the application of analytical chemistry, biocompatible chemical probes, and integrative omics help to advance the knowledge of metallodrug targeting profiles within a systemic perspective. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/ic | - |
dc.relation.ispartof | Inorganic Chemistry | - |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
dc.title | Metalloproteomics for unveiling the mechanism of action of metallodrugs | - |
dc.type | Article | - |
dc.identifier.email | Wang, Y: yuchuanw@HKUCC-COM.hku.hk | - |
dc.identifier.email | Li, H: hylichem@hku.hk | - |
dc.identifier.email | Sun, H: hsun@hku.hk | - |
dc.identifier.authority | Sun, H=rp00777 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acs.inorgchem.9b01199 | - |
dc.identifier.scopus | eid_2-s2.0-85073643226 | - |
dc.identifier.hkuros | 301432 | - |
dc.identifier.volume | 58 | - |
dc.identifier.issue | 20 | - |
dc.identifier.spage | 13673 | - |
dc.identifier.epage | 13685 | - |
dc.identifier.isi | WOS:000492117900014 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0020-1669 | - |