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Article: Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome

TitleRapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome
Authors
Keywordsbronchiolitis obliterans syndrome
graft versus host disease
haematopoietic stem cell transplantation
lung function decline
Issue Date2019
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
Citation
Respirology, 2019, v. 24 n. 5, p. 459-466 How to Cite?
AbstractBackground and objective: Bronchiolitis obliterans syndrome (BOS) after haematopoietic stem cell transplantation (HSCT) presents with lung function decline. The pattern of lung function decline after BOS diagnosis could impact prognostication of BOS as a complication after HSCT. The aim of this study was to assess the impact of lung function decline on overall survival (OS) in BOS subjects. Methods: Subjects with BOS were compared to those without BOS and matched for age, gender, primary diagnoses, conditioning regimes and chronic graft versus host disease. Lung function tests at baseline, at BOS diagnosis and every 3 months after HSCT were evaluated. Results: Of the 1461 subjects undergoing allogeneic HSCT (allo‐HSCT) between 1998 and 2015, 95 (6.5%) were diagnosed with BOS. A total of 159 matched HSCT recipients without BOS were identified. A 25% decline in FEV1 within the first 3 months after BOS diagnosis would separate BOS subjects into a subgroup with initial rapid decline and another subgroup with initial gradual decline in lung function. The rapid decline group showed lower subsequent lung function parameters and significantly worse OS compared to the gradual decline group (P = 0.013). Conclusion: Post‐HSCT BOS subjects with initial rapid lung function decline within 3 months after BOS diagnosis will have significantly poorer lung function and worse OS compared to those with initial gradual decline in lung function after BOS diagnosis. HSCT BOS patients with rapid initial decline in lung function warrant closer monitoring for the development of other post‐HSCT complications that could affect their survival.
Persistent Identifierhttp://hdl.handle.net/10722/273947
ISSN
2017 Impact Factor: 4.407
2015 SCImago Journal Rankings: 1.157

 

DC FieldValueLanguage
dc.contributor.authorKwok, WC-
dc.contributor.authorLiang, BM-
dc.contributor.authorLui, MMS-
dc.contributor.authorTam, TCC-
dc.contributor.authorSim, PYJ-
dc.contributor.authorTse, EWC-
dc.contributor.authorLeung, AYH-
dc.contributor.authorKwong, YL-
dc.contributor.authorLie, AKW-
dc.contributor.authorIp, MSM-
dc.contributor.authorLam, DCL-
dc.date.accessioned2019-08-18T14:51:55Z-
dc.date.available2019-08-18T14:51:55Z-
dc.date.issued2019-
dc.identifier.citationRespirology, 2019, v. 24 n. 5, p. 459-466-
dc.identifier.issn1323-7799-
dc.identifier.urihttp://hdl.handle.net/10722/273947-
dc.description.abstractBackground and objective: Bronchiolitis obliterans syndrome (BOS) after haematopoietic stem cell transplantation (HSCT) presents with lung function decline. The pattern of lung function decline after BOS diagnosis could impact prognostication of BOS as a complication after HSCT. The aim of this study was to assess the impact of lung function decline on overall survival (OS) in BOS subjects. Methods: Subjects with BOS were compared to those without BOS and matched for age, gender, primary diagnoses, conditioning regimes and chronic graft versus host disease. Lung function tests at baseline, at BOS diagnosis and every 3 months after HSCT were evaluated. Results: Of the 1461 subjects undergoing allogeneic HSCT (allo‐HSCT) between 1998 and 2015, 95 (6.5%) were diagnosed with BOS. A total of 159 matched HSCT recipients without BOS were identified. A 25% decline in FEV1 within the first 3 months after BOS diagnosis would separate BOS subjects into a subgroup with initial rapid decline and another subgroup with initial gradual decline in lung function. The rapid decline group showed lower subsequent lung function parameters and significantly worse OS compared to the gradual decline group (P = 0.013). Conclusion: Post‐HSCT BOS subjects with initial rapid lung function decline within 3 months after BOS diagnosis will have significantly poorer lung function and worse OS compared to those with initial gradual decline in lung function after BOS diagnosis. HSCT BOS patients with rapid initial decline in lung function warrant closer monitoring for the development of other post‐HSCT complications that could affect their survival.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES-
dc.relation.ispartofRespirology-
dc.rightsThis is the peer reviewed version of the following article: Respirology, 2019, v. 24 n. 5, p. 459-466, which has been published in final form at https://doi.org/10.1111/resp.13472. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectbronchiolitis obliterans syndrome-
dc.subjectgraft versus host disease-
dc.subjecthaematopoietic stem cell transplantation-
dc.subjectlung function decline-
dc.titleRapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome-
dc.typeArticle-
dc.identifier.emailLui, MMS: drmslui@hku.hk-
dc.identifier.emailTam, TCC: tamcct@hku.hk-
dc.identifier.emailSim, PYJ: jpysim@hku.hk-
dc.identifier.emailTse, EWC: ewctse@hku.hk-
dc.identifier.emailLeung, AYH: ayhleung@hku.hk-
dc.identifier.emailKwong, YL: ylkwong@hkucc.hku.hk-
dc.identifier.emailLie, AKW: akwlie@hkucc.hku.hk-
dc.identifier.emailIp, MSM: msmip@hku.hk-
dc.identifier.emailLam, DCL: dcllam@hku.hk-
dc.identifier.authorityTse, EWC=rp00471-
dc.identifier.authorityLeung, AYH=rp00265-
dc.identifier.authorityKwong, YL=rp00358-
dc.identifier.authorityIp, MSM=rp00347-
dc.identifier.authorityLam, DCL=rp01345-
dc.description.naturepostprint-
dc.identifier.doi10.1111/resp.13472-
dc.identifier.pmid30663178-
dc.identifier.scopuseid_2-s2.0-85060330158-
dc.identifier.hkuros302190-
dc.identifier.volume24-
dc.identifier.issue5-
dc.identifier.spage459-
dc.identifier.epage466-
dc.publisher.placeAustralia-

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