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Conference Paper: Left and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers

TitleLeft and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers
Authors
KeywordsVentricular function
Cardiooncology
Tissue doppler,Stress echocardiography
Issue Date2017
PublisherAmerican Heart Association. The Journal's web site is located at http://circ.ahajournals.org
Citation
American Heart Association Scientific Sessions 2017, Anaheim, CA, USA, 11-15 November 2017. Abstracts in Circulation, 2017, v. 136 n. Suppl. 1, Abstract 12306 How to Cite?
AbstractBackground: Little is known about cardiac functional reserves in childhood cancer survivors. We assessed the left (LV) and right ventricular (RV) functional reserve in anthracycline-treated long-term survivors of childhood cancers. Methods: 103 survivors (57 males) aged 25.0±5.8 years at 15.2±5.8 years after anthracycline therapy and 61 healthy controls (29 males) were studied. Tissue Doppler echocardiography was performed at rest and during supine bicycle exercise to assess mitral and tricuspid annular systolic (s) and early diastolic (e) velocities, and LV myocardial isovolumic acceleration (IVA). The slope of LV force-frequency relationship (FFR) was derived from the changes in IVA with heart rates during exercise (ΔIVA/Δheart rate). The LV and RV functional reserves were further assessed by the systolic (SFRI) and diastolic (DRFI) functional reserve indices, calculated respectively as Δs x [1-1/s at baseline] and Δe x [1-1/e at baseline]. Results: At baseline, mitral annular tissue Doppler indices were similar between survivors and controls (all p>0.05), while tricuspid s and e velocities were significantly lower in survivors (both p<0.05). The FFR slope (p<0.001), LV SFRI (p<0.001), and RV SFRI (p=0.001) were significantly lower in survivors than controls. For diastolic functional reserve, LV but not RV DFRI was significantly lower in survivors than controls (p<0.001). The LV SRFI and RV SRFI (r=0.28, p<0.001) were significantly associated. In patients, LV FFR and LV and RV functional reserve indices did not correlate with age, gender, follow-up duration, and cumulative dose of anthracycline received (all p>0.05) Conclusions: LV and RV functional reserves during exercise are impaired and interrelated in anthracycline-treated long-term survivors of childhood cancers.
DescriptionAbstract Poster Session CA.APS.05 - Cardiac Development, Structure and Function IV
Persistent Identifierhttp://hdl.handle.net/10722/274193
ISSN
2017 Impact Factor: 18.881
2015 SCImago Journal Rankings: 7.853

 

DC FieldValueLanguage
dc.contributor.authorLi, WYV-
dc.contributor.authorLiu, APY-
dc.contributor.authorWong, WHS-
dc.contributor.authorHo, KK-
dc.contributor.authorYau, JP-
dc.contributor.authorCheuk, KLD-
dc.contributor.authorCheung, YF-
dc.date.accessioned2019-08-18T14:56:59Z-
dc.date.available2019-08-18T14:56:59Z-
dc.date.issued2017-
dc.identifier.citationAmerican Heart Association Scientific Sessions 2017, Anaheim, CA, USA, 11-15 November 2017. Abstracts in Circulation, 2017, v. 136 n. Suppl. 1, Abstract 12306-
dc.identifier.issn0009-7322-
dc.identifier.urihttp://hdl.handle.net/10722/274193-
dc.descriptionAbstract Poster Session CA.APS.05 - Cardiac Development, Structure and Function IV-
dc.description.abstractBackground: Little is known about cardiac functional reserves in childhood cancer survivors. We assessed the left (LV) and right ventricular (RV) functional reserve in anthracycline-treated long-term survivors of childhood cancers. Methods: 103 survivors (57 males) aged 25.0±5.8 years at 15.2±5.8 years after anthracycline therapy and 61 healthy controls (29 males) were studied. Tissue Doppler echocardiography was performed at rest and during supine bicycle exercise to assess mitral and tricuspid annular systolic (s) and early diastolic (e) velocities, and LV myocardial isovolumic acceleration (IVA). The slope of LV force-frequency relationship (FFR) was derived from the changes in IVA with heart rates during exercise (ΔIVA/Δheart rate). The LV and RV functional reserves were further assessed by the systolic (SFRI) and diastolic (DRFI) functional reserve indices, calculated respectively as Δs x [1-1/s at baseline] and Δe x [1-1/e at baseline]. Results: At baseline, mitral annular tissue Doppler indices were similar between survivors and controls (all p>0.05), while tricuspid s and e velocities were significantly lower in survivors (both p<0.05). The FFR slope (p<0.001), LV SFRI (p<0.001), and RV SFRI (p=0.001) were significantly lower in survivors than controls. For diastolic functional reserve, LV but not RV DFRI was significantly lower in survivors than controls (p<0.001). The LV SRFI and RV SRFI (r=0.28, p<0.001) were significantly associated. In patients, LV FFR and LV and RV functional reserve indices did not correlate with age, gender, follow-up duration, and cumulative dose of anthracycline received (all p>0.05) Conclusions: LV and RV functional reserves during exercise are impaired and interrelated in anthracycline-treated long-term survivors of childhood cancers.-
dc.languageeng-
dc.publisherAmerican Heart Association. The Journal's web site is located at http://circ.ahajournals.org-
dc.relation.ispartofCirculation-
dc.relation.ispartofAmerican Heart Association Scientific Sessions 2017-
dc.subjectVentricular function-
dc.subjectCardiooncology-
dc.subjectTissue doppler,Stress echocardiography-
dc.titleLeft and right ventricular systolic and diastolic functional reserves are impaired in anthracycline-treated long-term survivors of childhood cancers-
dc.typeConference_Paper-
dc.identifier.emailLi, WYV: wyvli@hku.hk-
dc.identifier.emailLiu, APY: apyliu@hku.hk-
dc.identifier.emailWong, WHS: whswong@hku.hk-
dc.identifier.emailCheuk, KLD: klcheuk@hkucc.hku.hk-
dc.identifier.emailCheung, YF: xfcheung@hku.hk-
dc.identifier.authorityLiu, APY=rp01357-
dc.identifier.authorityCheung, YF=rp00382-
dc.identifier.hkuros301088-
dc.identifier.volume136-
dc.identifier.issueSuppl. 1-
dc.identifier.spageAbstract 12306-
dc.identifier.epageAbstract 12306-
dc.publisher.placeUnited States-

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