File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Strategies to Enhance the Photosensitization: Polymerization and the Donor-Acceptor Even-Odd Effect

TitleStrategies to Enhance the Photosensitization: Polymerization and the Donor-Acceptor Even-Odd Effect
Authors
Keywordsaggregation-induced emission
even–odd effect
fluorescence
photodynamic therapy
polymerization
Issue Date2018
PublisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie (International Edition), 2018, v. 57 n. 46, p. 15189-15193 How to Cite?
AbstractA particular challenge in the design of organic photosensitizers (PSs) with donor-acceptor (D-A) structures is that it is based on trial and error rather than specific rules. Now these challenges are addressed by proposing two efficient strategies to enhance the photosensitization efficiency: polymerization-facilitated photosensitization and the D-A even-odd effect. Conjugated polymers have been found to exhibit a higher O-1(2) generation efficiency than their small molecular counterparts. Furthermore, PSs with A-D-A structures show enhanced photosensitization efficiency over those with D-A-D structures. Theoretical calculations suggest an enhanced inter-system crossing (ISC) efficiency by these strategies. Both in vitro and in vivo experiments demonstrate that the resulting materials can be used as photosensitizers in image-guided photodynamic anticancer therapy. These guidelines are applicable to other polymers and small molecules to lead to the development of new PSs.
Persistent Identifierhttp://hdl.handle.net/10722/274403
ISSN
2019 Impact Factor: 12.959
2015 SCImago Journal Rankings: 6.229

 

DC FieldValueLanguage
dc.contributor.authorLiu, SJ-
dc.contributor.authorZhang, HK-
dc.contributor.authorLi, YY-
dc.contributor.authorLiu, JK-
dc.contributor.authorDu, L-
dc.contributor.authorChen, M-
dc.contributor.authorKwok, RTK-
dc.contributor.authorLam, JWY-
dc.contributor.authorPhillips, DL-
dc.contributor.authorTang, BZ-
dc.date.accessioned2019-08-18T15:01:03Z-
dc.date.available2019-08-18T15:01:03Z-
dc.date.issued2018-
dc.identifier.citationAngewandte Chemie (International Edition), 2018, v. 57 n. 46, p. 15189-15193-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/274403-
dc.description.abstractA particular challenge in the design of organic photosensitizers (PSs) with donor-acceptor (D-A) structures is that it is based on trial and error rather than specific rules. Now these challenges are addressed by proposing two efficient strategies to enhance the photosensitization efficiency: polymerization-facilitated photosensitization and the D-A even-odd effect. Conjugated polymers have been found to exhibit a higher O-1(2) generation efficiency than their small molecular counterparts. Furthermore, PSs with A-D-A structures show enhanced photosensitization efficiency over those with D-A-D structures. Theoretical calculations suggest an enhanced inter-system crossing (ISC) efficiency by these strategies. Both in vitro and in vivo experiments demonstrate that the resulting materials can be used as photosensitizers in image-guided photodynamic anticancer therapy. These guidelines are applicable to other polymers and small molecules to lead to the development of new PSs.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home-
dc.relation.ispartofAngewandte Chemie (International Edition)-
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectaggregation-induced emission-
dc.subjecteven–odd effect-
dc.subjectfluorescence-
dc.subjectphotodynamic therapy-
dc.subjectpolymerization-
dc.titleStrategies to Enhance the Photosensitization: Polymerization and the Donor-Acceptor Even-Odd Effect-
dc.typeArticle-
dc.identifier.emailDu, L: ailleen@hku.hk-
dc.identifier.emailPhillips, DL: phillips@hku.hk-
dc.identifier.authorityPhillips, DL=rp00770-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.201810326-
dc.identifier.pmid30253012-
dc.identifier.scopuseid_2-s2.0-85055249388-
dc.identifier.hkuros300965-
dc.identifier.volume57-
dc.identifier.issue46-
dc.identifier.spage15189-
dc.identifier.epage15193-
dc.publisher.placeGermany-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats