File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases

TitleThe beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases
Authors
KeywordsExercise
Motor Activity
Cognitive training
Issue Date2019
PublisherSpringer for United States and Canadian Academy of Pathology (USCAP). The Journal's web site is located at http://www.nature.com/labinvest/
Citation
Laboratory Investigation, 2019, v. 99, p. 943-957 How to Cite?
AbstractGrowing evidence has shown the beneficial influence of exercise on humans. Apart from classic cardioprotection, numerous studies have demonstrated that different exercise regimes provide a substantial improvement in various brain functions. Although the underlying mechanism is yet to be determined, emerging evidence for neuroprotection has been established in both humans and experimental animals, with most of the valuable findings in the field of mental health, neurodegenerative diseases, and acquired brain injuries. This review will discuss the recent findings of how exercise could ameliorate brain function in neuropathological states, demonstrated by either clinical or laboratory animal studies. Simultaneously, state-of-the-art molecular mechanisms underlying the exercise-induced neuroprotective effects and comparison between different types of exercise will be discussed in detail. A majority of reports show that physical exercise is associated with enhanced cognition throughout different populations and remains as a fascinating area in scientific research because of its universal protective effects in different brain domain functions. This article is to review what we know about how physical exercise modulates the pathophysiological mechanisms of neurodegeneration.
Persistent Identifierhttp://hdl.handle.net/10722/274588
ISSN
2017 Impact Factor: 4.263
2015 SCImago Journal Rankings: 2.133

 

DC FieldValueLanguage
dc.contributor.authorLIU, Y-
dc.contributor.authorYan, T-
dc.contributor.authorChu, JMT-
dc.contributor.authorCHEN, Y-
dc.contributor.authorDUNNETT, S-
dc.contributor.authorHo, YS-
dc.contributor.authorWong, GTC-
dc.contributor.authorChang, RCC-
dc.date.accessioned2019-08-18T15:04:47Z-
dc.date.available2019-08-18T15:04:47Z-
dc.date.issued2019-
dc.identifier.citationLaboratory Investigation, 2019, v. 99, p. 943-957-
dc.identifier.issn0023-6837-
dc.identifier.urihttp://hdl.handle.net/10722/274588-
dc.description.abstractGrowing evidence has shown the beneficial influence of exercise on humans. Apart from classic cardioprotection, numerous studies have demonstrated that different exercise regimes provide a substantial improvement in various brain functions. Although the underlying mechanism is yet to be determined, emerging evidence for neuroprotection has been established in both humans and experimental animals, with most of the valuable findings in the field of mental health, neurodegenerative diseases, and acquired brain injuries. This review will discuss the recent findings of how exercise could ameliorate brain function in neuropathological states, demonstrated by either clinical or laboratory animal studies. Simultaneously, state-of-the-art molecular mechanisms underlying the exercise-induced neuroprotective effects and comparison between different types of exercise will be discussed in detail. A majority of reports show that physical exercise is associated with enhanced cognition throughout different populations and remains as a fascinating area in scientific research because of its universal protective effects in different brain domain functions. This article is to review what we know about how physical exercise modulates the pathophysiological mechanisms of neurodegeneration.-
dc.languageeng-
dc.publisherSpringer for United States and Canadian Academy of Pathology (USCAP). The Journal's web site is located at http://www.nature.com/labinvest/-
dc.relation.ispartofLaboratory Investigation-
dc.subjectExercise-
dc.subjectMotor Activity-
dc.subjectCognitive training-
dc.titleThe beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases-
dc.typeArticle-
dc.identifier.emailChu, JMT: jmtchu@hku.hk-
dc.identifier.emailWong, GTC: gordon@hku.hk-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.authorityWong, GTC=rp00523-
dc.identifier.authorityChang, RCC=rp00470-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41374-019-0232-y-
dc.identifier.pmid30808929-
dc.identifier.scopuseid_2-s2.0-85062301110-
dc.identifier.hkuros302294-
dc.identifier.volume99-
dc.identifier.spage943-
dc.identifier.epage957-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats