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Article: Selective catecholamine detection in living cells by a copper-mediated oxidative bond cleavage

TitleSelective catecholamine detection in living cells by a copper-mediated oxidative bond cleavage
Authors
Issue Date2019
PublisherRoyal Society of Chemistry: Open Access. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp
Citation
Chemical Science, 2019, v. 10 n. 37, p. 8519-8526 How to Cite?
AbstractThe development of a new triggered-release system for selective detection of catecholamines in biological samples including living cells is reported. Catecholamines are a class of tightly regulated hormones and neurotransmitters in the human body and their dysregulation is implicated in various neurodegenerative diseases. It is highly challenging to selectively sense and detect catecholamines in a complex biological environment due to their small size, non-specific molecular shape and trivial chemical properties. In this study, a copper-based, catecholamine-triggered oxidation that releases a fluorescent reporter is described. The probe is highly sensitive and selective for detecting changes in catecholamine levels in aqueous buffer, human plasma, and cellular models of neuronal differentiation and Parkinson's disease. This new catecholamine sensing strategy features chemical reactivity as part of small molecule recognition as opposed to the conventional use of a well-designed host for reversible binding. © 2019 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/274826
ISSN
2019 Impact Factor: 9.346
2015 SCImago Journal Rankings: 4.974
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTong, KY-
dc.contributor.authorZhao, J-
dc.contributor.authorTse, CW-
dc.contributor.authorWan, PK-
dc.contributor.authorRong, J-
dc.contributor.authorAu Yeung, HY-
dc.date.accessioned2019-09-10T02:29:36Z-
dc.date.available2019-09-10T02:29:36Z-
dc.date.issued2019-
dc.identifier.citationChemical Science, 2019, v. 10 n. 37, p. 8519-8526-
dc.identifier.issn2041-6520-
dc.identifier.urihttp://hdl.handle.net/10722/274826-
dc.description.abstractThe development of a new triggered-release system for selective detection of catecholamines in biological samples including living cells is reported. Catecholamines are a class of tightly regulated hormones and neurotransmitters in the human body and their dysregulation is implicated in various neurodegenerative diseases. It is highly challenging to selectively sense and detect catecholamines in a complex biological environment due to their small size, non-specific molecular shape and trivial chemical properties. In this study, a copper-based, catecholamine-triggered oxidation that releases a fluorescent reporter is described. The probe is highly sensitive and selective for detecting changes in catecholamine levels in aqueous buffer, human plasma, and cellular models of neuronal differentiation and Parkinson's disease. This new catecholamine sensing strategy features chemical reactivity as part of small molecule recognition as opposed to the conventional use of a well-designed host for reversible binding. © 2019 The Royal Society of Chemistry.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry: Open Access. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp-
dc.relation.ispartofChemical Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSelective catecholamine detection in living cells by a copper-mediated oxidative bond cleavage-
dc.typeArticle-
dc.identifier.emailZhao, J: zhaojia7@hku.hk-
dc.identifier.emailWan, PK: kiwanhk@hku.hk-
dc.identifier.emailRong, J: jrong@hku.hk-
dc.identifier.emailAu Yeung, HY: hoyuay@hku.hk-
dc.identifier.authorityRong, J=rp00515-
dc.identifier.authorityAu Yeung, HY=rp01819-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1039/C9SC03338F-
dc.identifier.scopuseid_2-s2.0-85072674516-
dc.identifier.hkuros303633-
dc.identifier.volume10-
dc.identifier.issue37-
dc.identifier.spage8519-
dc.identifier.epage8526-
dc.identifier.isiWOS:000487674500022-
dc.publisher.placeUnited Kingdom-

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