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Article: Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance
Title | Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance |
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Authors | |
Keywords | adaptive thermogenesis adenosine monophosphate-activated protein kinase adipose tissue beiging food intake |
Issue Date | 2018 |
Publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms |
Citation | International Journal of Molecular Sciences, 2018, v. 19 n. 11, article no. 3552 How to Cite? |
Abstract | As a cellular energy sensor and regulator, adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays a pivotal role in the regulation of energy homeostasis in both the central nervous system (CNS) and peripheral organs. Activation of hypothalamic AMPK maintains energy balance by inducing appetite to increase food intake and diminishing adaptive thermogenesis in adipose tissues to reduce energy expenditure in response to food deprivation. Numerous metabolic hormones, such as leptin, adiponectin, ghrelin and insulin, exert their energy regulatory effects through hypothalamic AMPK via integration with the neural circuits. Although activation of AMPK in peripheral tissues is able to promote fatty acid oxidation and insulin sensitivity, its chronic activation in the hypothalamus causes obesity by inducing hyperphagia in both humans and rodents. In this review, we discuss the role of hypothalamic AMPK in mediating hormonal regulation of feeding and adaptive thermogenesis, and summarize the diverse underlying mechanisms by which central AMPK maintains energy homeostasis. |
Persistent Identifier | http://hdl.handle.net/10722/275100 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, B | - |
dc.contributor.author | Cheng, KK | - |
dc.date.accessioned | 2019-09-10T02:35:28Z | - |
dc.date.available | 2019-09-10T02:35:28Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2018, v. 19 n. 11, article no. 3552 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/275100 | - |
dc.description.abstract | As a cellular energy sensor and regulator, adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays a pivotal role in the regulation of energy homeostasis in both the central nervous system (CNS) and peripheral organs. Activation of hypothalamic AMPK maintains energy balance by inducing appetite to increase food intake and diminishing adaptive thermogenesis in adipose tissues to reduce energy expenditure in response to food deprivation. Numerous metabolic hormones, such as leptin, adiponectin, ghrelin and insulin, exert their energy regulatory effects through hypothalamic AMPK via integration with the neural circuits. Although activation of AMPK in peripheral tissues is able to promote fatty acid oxidation and insulin sensitivity, its chronic activation in the hypothalamus causes obesity by inducing hyperphagia in both humans and rodents. In this review, we discuss the role of hypothalamic AMPK in mediating hormonal regulation of feeding and adaptive thermogenesis, and summarize the diverse underlying mechanisms by which central AMPK maintains energy homeostasis. | - |
dc.language | eng | - |
dc.publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | adaptive thermogenesis | - |
dc.subject | adenosine monophosphate-activated protein kinase | - |
dc.subject | adipose tissue | - |
dc.subject | beiging | - |
dc.subject | food intake | - |
dc.title | Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance | - |
dc.type | Article | - |
dc.identifier.email | Wang, B: baile612@hku.hk | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/ijms19113552 | - |
dc.identifier.pmid | 30423881 | - |
dc.identifier.pmcid | PMC6274700 | - |
dc.identifier.scopus | eid_2-s2.0-85056525028 | - |
dc.identifier.hkuros | 304287 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | article no. 3552 | - |
dc.identifier.epage | article no. 3552 | - |
dc.identifier.isi | WOS:000451528500268 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1422-0067 | - |