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Article: Practical Direct α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis

TitlePractical Direct α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis
Authors
Keywordssynthetic methods
arylation
homogeneous catalysis
ketones
palladium
Issue Date2016
Citation
Angewandte Chemie - International Edition, 2016, v. 55, n. 7, p. 2559-2563 How to Cite?
Abstract© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Direct arylation of cyclopentanones has been a long-standing challenge because of competitive self-aldol condensation and multiple arylations. Reported herein is a direct mono-α-C-H arylation of cyclopentanones with aryl bromides which is enabled by palladium/amine cooperative catalysis. This method is scalable and chemoselective with broad functional-group tolerance. Application to controlled sequential arylation of cyclopentanones has been also demonstrated. Be direct: A direct α-C-H arylation of normal cyclopentanones with aryl bromides, enabled by palladium/amine cooperative catalysis, features an exceptionally high selectivity for monoarylation, use of readily available starting materials, good scalability, and broad functional-group tolerance.
Persistent Identifierhttp://hdl.handle.net/10722/276501
ISSN
2019 Impact Factor: 12.959
2015 SCImago Journal Rankings: 6.229

 

DC FieldValueLanguage
dc.contributor.authorXu, Yan-
dc.contributor.authorSu, Tianshun-
dc.contributor.authorHuang, Zhongxing-
dc.contributor.authorDong, Guangbin-
dc.date.accessioned2019-09-18T08:33:48Z-
dc.date.available2019-09-18T08:33:48Z-
dc.date.issued2016-
dc.identifier.citationAngewandte Chemie - International Edition, 2016, v. 55, n. 7, p. 2559-2563-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/276501-
dc.description.abstract© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Direct arylation of cyclopentanones has been a long-standing challenge because of competitive self-aldol condensation and multiple arylations. Reported herein is a direct mono-α-C-H arylation of cyclopentanones with aryl bromides which is enabled by palladium/amine cooperative catalysis. This method is scalable and chemoselective with broad functional-group tolerance. Application to controlled sequential arylation of cyclopentanones has been also demonstrated. Be direct: A direct α-C-H arylation of normal cyclopentanones with aryl bromides, enabled by palladium/amine cooperative catalysis, features an exceptionally high selectivity for monoarylation, use of readily available starting materials, good scalability, and broad functional-group tolerance.-
dc.languageeng-
dc.relation.ispartofAngewandte Chemie - International Edition-
dc.subjectsynthetic methods-
dc.subjectarylation-
dc.subjecthomogeneous catalysis-
dc.subjectketones-
dc.subjectpalladium-
dc.titlePractical Direct α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.201510638-
dc.identifier.scopuseid_2-s2.0-84954413534-
dc.identifier.volume55-
dc.identifier.issue7-
dc.identifier.spage2559-
dc.identifier.epage2563-
dc.identifier.eissn1521-3773-

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