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Article: Mechanical and biological evaluations of novel electrospun PLLA composite scaffolds doped with oxide ceramics

TitleMechanical and biological evaluations of novel electrospun PLLA composite scaffolds doped with oxide ceramics
Authors
KeywordsScaffolds
PLLA
Oxide ceramic
Osteogenesis
Electrospinning
Issue Date2019
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/issn/17516161
Citation
Journal of the Mechanical Behavior of Biomedical Materials, 2019, v. 97, p. 229-237 How to Cite?
AbstractThe objective of this study is to evaluate the in vitro performance of the novel electrospun composite scaffolds that are made of 10% PLLA in binary solvents (75 vol% dichloromethane: 25 vol% acetone) doped with 0.1 wt% of oxide ceramic powders (Hafnium dioxide (HfO2), titanium dioxide (TiO2), zirconium dioxide (ZrO2) and silicon dioxide (SiO2)). These composite scaffolds were characterized microscopically (SEM, TEM and EDX), mechanically (Vickers hardness and tensile strength) and in in vitro cell studies (biomineralization, protein absorption, and cytocompatibility) with MC3T3 pre-osteoblasts. The combination of PLLA polymer with oxide ceramics was indicated to be able to provide osteogenic properties that can enhance osteoblastic cell proliferation. In particular, results from the study demonstrated that the presence of zirconia and hafnia in the PLLA/ZrO2 and PLLA/HfO2 composite scaffolds could increase cell proliferation, protein adsorption and biomineralization properties significantly more than other two groups’ scaffolds. PLLA/TiO2 provided the best mechanical strength than others (p < 0.05). To conclude, the novel composite scaffolds, which are promising biomaterials for tissue engineering, could be manufactured easily by electrospinning techniques.
Persistent Identifierhttp://hdl.handle.net/10722/278095
ISSN
2019 Impact Factor: 3.372
2015 SCImago Journal Rankings: 1.068

 

DC FieldValueLanguage
dc.contributor.authorCHAN, K-
dc.contributor.authorTsoi, JKH-
dc.contributor.authorWu, OK-
dc.contributor.authorYon, MJY-
dc.contributor.authorWong, RWK-
dc.date.accessioned2019-10-04T08:07:24Z-
dc.date.available2019-10-04T08:07:24Z-
dc.date.issued2019-
dc.identifier.citationJournal of the Mechanical Behavior of Biomedical Materials, 2019, v. 97, p. 229-237-
dc.identifier.issn1751-6161-
dc.identifier.urihttp://hdl.handle.net/10722/278095-
dc.description.abstractThe objective of this study is to evaluate the in vitro performance of the novel electrospun composite scaffolds that are made of 10% PLLA in binary solvents (75 vol% dichloromethane: 25 vol% acetone) doped with 0.1 wt% of oxide ceramic powders (Hafnium dioxide (HfO2), titanium dioxide (TiO2), zirconium dioxide (ZrO2) and silicon dioxide (SiO2)). These composite scaffolds were characterized microscopically (SEM, TEM and EDX), mechanically (Vickers hardness and tensile strength) and in in vitro cell studies (biomineralization, protein absorption, and cytocompatibility) with MC3T3 pre-osteoblasts. The combination of PLLA polymer with oxide ceramics was indicated to be able to provide osteogenic properties that can enhance osteoblastic cell proliferation. In particular, results from the study demonstrated that the presence of zirconia and hafnia in the PLLA/ZrO2 and PLLA/HfO2 composite scaffolds could increase cell proliferation, protein adsorption and biomineralization properties significantly more than other two groups’ scaffolds. PLLA/TiO2 provided the best mechanical strength than others (p < 0.05). To conclude, the novel composite scaffolds, which are promising biomaterials for tissue engineering, could be manufactured easily by electrospinning techniques.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/issn/17516161-
dc.relation.ispartofJournal of the Mechanical Behavior of Biomedical Materials-
dc.subjectScaffolds-
dc.subjectPLLA-
dc.subjectOxide ceramic-
dc.subjectOsteogenesis-
dc.subjectElectrospinning-
dc.titleMechanical and biological evaluations of novel electrospun PLLA composite scaffolds doped with oxide ceramics-
dc.typeArticle-
dc.identifier.emailTsoi, JKH: jkhtsoi@hku.hk-
dc.identifier.authorityTsoi, JKH=rp01609-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jmbbm.2019.05.024-
dc.identifier.pmid31132659-
dc.identifier.scopuseid_2-s2.0-85066034636-
dc.identifier.hkuros306320-
dc.identifier.volume97-
dc.identifier.spage229-
dc.identifier.epage237-
dc.publisher.placeNetherlands-

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