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- Publisher Website: 10.1002/adfm.201800299
- Scopus: eid_2-s2.0-85047659193
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Article: Rapid Sterilization and Accelerated Wound Healing Using Zn2+ and Graphene Oxide Modified g-C3N4 under Dual Light Irradiation
Title | Rapid Sterilization and Accelerated Wound Healing Using Zn2+ and Graphene Oxide Modified g-C3N4 under Dual Light Irradiation |
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Authors | |
Keywords | antibacterials g‐C3N4 photodynamic therapy photothermal therapy wound healing |
Issue Date | 2018 |
Publisher | Wiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/afm |
Citation | Advanced Functional Materials, 2018, v. 28 n. 30, p. article no. 1800299 How to Cite? |
Abstract | Wound healing is affected by bacterial infection and related inflammation, cell proliferation and differentiation, and tissue remodeling. Current antibiotics therapy cannot promote wound healing and kill bacteria at the same time. Herein, hybrid nanosheets of g‐C3N4‐Zn2+@graphene oxide (SCN‐Zn2+@GO) are prepared by combining Zn2+ doped sheet‐like g‐C3N4 with graphene oxide via electrostatic bonding and π–π stacking interactions to assist wound healing and kill bacteria simultaneously by short‐time exposure to 660 and 808 nm light. The gene expressions of matrix metalloproteinase‐2, type I collagen, type III collagen, and interleukin β in fibroblasts are regulated by GO and released Zn2+, which can accelerate wound healing. Co‐irradiation produces an antibacterial ratio over 99.1% within a short time because of the synergistic effects of both photodynamic antibacterial and photothermal antibacterial treatments. The hyperthermia produced by 808 nm light illumination can weaken the bacterial activity. And these bacteria can be easily killed by membrane destruction, protein denaturation, and disruption of bacterial metabolic pathways due to reactive oxygen species produced under 660 nm light irradiation. This strategy of Zn2+ and GO modification can increase the antibacterial efficacy of SCN and accelerate wound healing at the same time, which makes this SCN‐Zn2+@GO be very promising in bacteria‐infected wound healing therapy. |
Persistent Identifier | http://hdl.handle.net/10722/278225 |
ISSN | 2023 Impact Factor: 18.5 2023 SCImago Journal Rankings: 5.496 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LI, Y | - |
dc.contributor.author | LIU, X | - |
dc.contributor.author | TAN, L | - |
dc.contributor.author | CUI, Z | - |
dc.contributor.author | YANG, X | - |
dc.contributor.author | ZHENG, Y | - |
dc.contributor.author | Yeung, KWK | - |
dc.contributor.author | CHU, PK | - |
dc.contributor.author | WU, S | - |
dc.date.accessioned | 2019-10-04T08:09:54Z | - |
dc.date.available | 2019-10-04T08:09:54Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Advanced Functional Materials, 2018, v. 28 n. 30, p. article no. 1800299 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | http://hdl.handle.net/10722/278225 | - |
dc.description.abstract | Wound healing is affected by bacterial infection and related inflammation, cell proliferation and differentiation, and tissue remodeling. Current antibiotics therapy cannot promote wound healing and kill bacteria at the same time. Herein, hybrid nanosheets of g‐C3N4‐Zn2+@graphene oxide (SCN‐Zn2+@GO) are prepared by combining Zn2+ doped sheet‐like g‐C3N4 with graphene oxide via electrostatic bonding and π–π stacking interactions to assist wound healing and kill bacteria simultaneously by short‐time exposure to 660 and 808 nm light. The gene expressions of matrix metalloproteinase‐2, type I collagen, type III collagen, and interleukin β in fibroblasts are regulated by GO and released Zn2+, which can accelerate wound healing. Co‐irradiation produces an antibacterial ratio over 99.1% within a short time because of the synergistic effects of both photodynamic antibacterial and photothermal antibacterial treatments. The hyperthermia produced by 808 nm light illumination can weaken the bacterial activity. And these bacteria can be easily killed by membrane destruction, protein denaturation, and disruption of bacterial metabolic pathways due to reactive oxygen species produced under 660 nm light irradiation. This strategy of Zn2+ and GO modification can increase the antibacterial efficacy of SCN and accelerate wound healing at the same time, which makes this SCN‐Zn2+@GO be very promising in bacteria‐infected wound healing therapy. | - |
dc.language | eng | - |
dc.publisher | Wiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/afm | - |
dc.relation.ispartof | Advanced Functional Materials | - |
dc.rights | This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | antibacterials | - |
dc.subject | g‐C3N4 | - |
dc.subject | photodynamic therapy | - |
dc.subject | photothermal therapy | - |
dc.subject | wound healing | - |
dc.title | Rapid Sterilization and Accelerated Wound Healing Using Zn2+ and Graphene Oxide Modified g-C3N4 under Dual Light Irradiation | - |
dc.type | Article | - |
dc.identifier.email | Yeung, KWK: wkkyeung@hku.hk | - |
dc.identifier.authority | Yeung, KWK=rp00309 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/adfm.201800299 | - |
dc.identifier.scopus | eid_2-s2.0-85047659193 | - |
dc.identifier.hkuros | 306866 | - |
dc.identifier.volume | 28 | - |
dc.identifier.issue | 30 | - |
dc.identifier.spage | article no. 1800299 | - |
dc.identifier.epage | article no. 1800299 | - |
dc.identifier.isi | WOS:000439738200004 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 1616-301X | - |