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Conference Paper: Multiple alterations on genes encoding components of the SWItch/Sucrose Non-Fermentable complex could be found in human papillomavirus-negative cervical cancer.
Title | Multiple alterations on genes encoding components of the SWItch/Sucrose Non-Fermentable complex could be found in human papillomavirus-negative cervical cancer. |
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Authors | |
Issue Date | 2019 |
Publisher | American Association for Cancer Research (AACR). |
Citation | AACR International Conference New Horizons in Cancer Research, Shenzhen, China, 3-5 May 2019 How to Cite? |
Abstract | Cervical cancer without apparent association with human papillomavirus (HPV) infection is a rare type of
the malignancy with poor prognosis but little is known about it. With HPV vaccine becoming widely accepted, it is expected that the proportion of HPV-negative cancer will rise. Understanding the molecular etiology of HPVnegative cancer is therefore important for the management of cervical cancer in the future. To compare the genetics of HPV-negative and -positive tumors, we characterized the coding genomes of 24 cervical cancers with known high-risk HPV (hrHPV) statues verified by INNO-LiPA HPV Genotyping Extra II assay using whole-exome sequencing (WES). In total we analyzed 4 HPV-negative and 20 HPV-positive cervical cancer samples by WES. There was no significant difference between the number of nonsynonymous SNPs and INDELs between HPV-negative and HPV-positive cancers. Here a preliminary analysis of the WES data focusing on 27 genes encoding components of the (SWItch/Sucrose Non-Fermentable) SWI/SNF complex is presented. In contrast to previous genomic data form TCGA, no protein changing SNP or INDEL was identified on ARID1A. Instead a small insertion adding one amino acid to the ARID1B protein was found in one of the HPV-negative cancers but not in the HPV-positive cases. Several SNPs were also found on some other genes encoding subunits of SWI/SNF complex in at least one of the HPV-negative cancers. Our data suggested that while mutations in SWI/ SNF complex are common among HPV-negative cervical
cancers, the genetic makeup of HPV-negative cervical cancer may be more diversified than previously identified. |
Description | Poster Session A - no. A32 |
Persistent Identifier | http://hdl.handle.net/10722/278353 |
DC Field | Value | Language |
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dc.contributor.author | Wong, OGW | - |
dc.contributor.author | Cheung, CLY | - |
dc.contributor.author | Liu, S | - |
dc.contributor.author | Ngan, HYS | - |
dc.contributor.author | Cheung, ANY | - |
dc.date.accessioned | 2019-10-04T08:12:22Z | - |
dc.date.available | 2019-10-04T08:12:22Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | AACR International Conference New Horizons in Cancer Research, Shenzhen, China, 3-5 May 2019 | - |
dc.identifier.uri | http://hdl.handle.net/10722/278353 | - |
dc.description | Poster Session A - no. A32 | - |
dc.description.abstract | Cervical cancer without apparent association with human papillomavirus (HPV) infection is a rare type of the malignancy with poor prognosis but little is known about it. With HPV vaccine becoming widely accepted, it is expected that the proportion of HPV-negative cancer will rise. Understanding the molecular etiology of HPVnegative cancer is therefore important for the management of cervical cancer in the future. To compare the genetics of HPV-negative and -positive tumors, we characterized the coding genomes of 24 cervical cancers with known high-risk HPV (hrHPV) statues verified by INNO-LiPA HPV Genotyping Extra II assay using whole-exome sequencing (WES). In total we analyzed 4 HPV-negative and 20 HPV-positive cervical cancer samples by WES. There was no significant difference between the number of nonsynonymous SNPs and INDELs between HPV-negative and HPV-positive cancers. Here a preliminary analysis of the WES data focusing on 27 genes encoding components of the (SWItch/Sucrose Non-Fermentable) SWI/SNF complex is presented. In contrast to previous genomic data form TCGA, no protein changing SNP or INDEL was identified on ARID1A. Instead a small insertion adding one amino acid to the ARID1B protein was found in one of the HPV-negative cancers but not in the HPV-positive cases. Several SNPs were also found on some other genes encoding subunits of SWI/SNF complex in at least one of the HPV-negative cancers. Our data suggested that while mutations in SWI/ SNF complex are common among HPV-negative cervical cancers, the genetic makeup of HPV-negative cervical cancer may be more diversified than previously identified. | - |
dc.language | eng | - |
dc.publisher | American Association for Cancer Research (AACR). | - |
dc.relation.ispartof | AACR New Horizons in Cancer Research Conference, 2019 | - |
dc.title | Multiple alterations on genes encoding components of the SWItch/Sucrose Non-Fermentable complex could be found in human papillomavirus-negative cervical cancer. | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Wong, OGW: wonggw@hkucc.hku.hk | - |
dc.identifier.email | Cheung, CLY: lycheung@pathology.hku.hk | - |
dc.identifier.email | Liu, S: stephasl@hku.hk | - |
dc.identifier.email | Ngan, HYS: hysngan@hkucc.hku.hk | - |
dc.identifier.email | Cheung, ANY: anycheun@hkucc.hku.hk | - |
dc.identifier.authority | Liu, S=rp00372 | - |
dc.identifier.authority | Ngan, HYS=rp00346 | - |
dc.identifier.authority | Cheung, ANY=rp00542 | - |
dc.identifier.hkuros | 306732 | - |