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Conference Paper: Optogenetically-evoked spindle-like activity from thalamus propagates brain-wide and enhances rsfMRI connectivity
Title | Optogenetically-evoked spindle-like activity from thalamus propagates brain-wide and enhances rsfMRI connectivity |
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Authors | |
Issue Date | 2019 |
Publisher | International Society for Magnetic Resonance in Medicine. |
Citation | The 27th Annual Meeting & Exhibition of International Society for Magnetic Resonance in Medicine (ISMRM), Montreal, Canada, 11-16 May 2019 , paper 3752 How to Cite? |
Abstract | Hierarchical nesting of spindles and slow oscillations have been identified as a unique characteristic for long-range functional neural integrations in thalamo-corticalnetwork. Meanwhile, low spontaneous oscillatory neural activities are proposed to constrain and elicit resting state fMRI connectivity. Yet, the brain-wide spindle-related BOLD activity and the contribution of thalamic spindle-like activity to brain-wide rsfMRI connectivity remain largely unknown. We demonstrate for the first time that the spindle-like optogenetic stimulation at the somatosensory thalamus can evoke robust BOLD activations brain-wide and influence brain-wide rsfMRI connectivity. Our work suggests that interaction between spindles and slow oscillations is important for maintain rsfMRI connectivity. |
Description | Digital Poster Session: fMRI: Multimodal fMRI - no. 3752 |
Persistent Identifier | http://hdl.handle.net/10722/278723 |
DC Field | Value | Language |
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dc.contributor.author | Wang, X | - |
dc.contributor.author | Leong, TL | - |
dc.contributor.author | Guo, S | - |
dc.contributor.author | Dong, M | - |
dc.contributor.author | Wu, EX | - |
dc.date.accessioned | 2019-10-21T02:12:50Z | - |
dc.date.available | 2019-10-21T02:12:50Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | The 27th Annual Meeting & Exhibition of International Society for Magnetic Resonance in Medicine (ISMRM), Montreal, Canada, 11-16 May 2019 , paper 3752 | - |
dc.identifier.uri | http://hdl.handle.net/10722/278723 | - |
dc.description | Digital Poster Session: fMRI: Multimodal fMRI - no. 3752 | - |
dc.description.abstract | Hierarchical nesting of spindles and slow oscillations have been identified as a unique characteristic for long-range functional neural integrations in thalamo-corticalnetwork. Meanwhile, low spontaneous oscillatory neural activities are proposed to constrain and elicit resting state fMRI connectivity. Yet, the brain-wide spindle-related BOLD activity and the contribution of thalamic spindle-like activity to brain-wide rsfMRI connectivity remain largely unknown. We demonstrate for the first time that the spindle-like optogenetic stimulation at the somatosensory thalamus can evoke robust BOLD activations brain-wide and influence brain-wide rsfMRI connectivity. Our work suggests that interaction between spindles and slow oscillations is important for maintain rsfMRI connectivity. | - |
dc.language | eng | - |
dc.publisher | International Society for Magnetic Resonance in Medicine. | - |
dc.relation.ispartof | 2019 Proceedings of International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting | - |
dc.title | Optogenetically-evoked spindle-like activity from thalamus propagates brain-wide and enhances rsfMRI connectivity | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Leong, TL: tlleong@hku.hk | - |
dc.identifier.email | Guo, S: shuaiguo@hku.hk | - |
dc.identifier.email | Wu, EX: ewu@eee.hku.hk | - |
dc.identifier.authority | Leong, TL=rp02483 | - |
dc.identifier.authority | Wu, EX=rp00193 | - |
dc.identifier.hkuros | 307710 | - |
dc.identifier.spage | p3752 | - |
dc.identifier.epage | p3752 | - |