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Article: Bone Targeted Delivery of SDF-1 via Alendronate Functionalized Nanoparticles in Guiding Stem Cell Migration

TitleBone Targeted Delivery of SDF-1 via Alendronate Functionalized Nanoparticles in Guiding Stem Cell Migration
Authors
Keywordsbone targeting
gene delivery
stem cell homing
SDF-1
osteoporosis therapy
Issue Date2018
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick
Citation
ACS Applied Materials & Interfaces, 2018, v. 10 n. 28, p. 23700-23710 How to Cite?
AbstractStem cells are well-known for their great capacity for tissue regeneration. This provides a promising source for cell-based therapies in treating various bone degenerative disorders. However, the major hurdles for their application in transplantation are the poor bone marrow homing and engraftment efficiencies. Stromal cell-derived factor 1 (SDF-1) has been identified as a major stem cell homing factor. With the aims of bone targeted SDF-1 delivery and regulating MSCs migration, alendronate modified liposomal nanoparticles (Aln-Lipo) carrying SDF-1 gene were developed in this study. Alendronate modification significantly increased the mineral binding affinity of liposomes, and facilitated the gene delivery to osteoblastic cells. Up-regulated SDF-1 expression in osteoblasts triggered MSCs migration. Systemic infusion of Aln-Lipo-SDF-1 with fluorescence labeling in mice showed the accumulation in osseous tissue by biophotonic imaging. Corresponding to the delivered SDF-1, the transplanted GFP+ MSCs were attracted to bone marrow and contributed to bone regeneration. This study may provide a useful technique in regulating stem cell migration.
Persistent Identifierhttp://hdl.handle.net/10722/278942
ISSN
2017 Impact Factor: 8.097
2015 SCImago Journal Rankings: 2.381

 

DC FieldValueLanguage
dc.contributor.authorCHEN, Q-
dc.contributor.authorZHENG, C-
dc.contributor.authorLI, Y-
dc.contributor.authorBIAN, S-
dc.contributor.authorPAN, H-
dc.contributor.authorZHAO, X-
dc.contributor.authorLu, WW-
dc.date.accessioned2019-10-21T02:16:46Z-
dc.date.available2019-10-21T02:16:46Z-
dc.date.issued2018-
dc.identifier.citationACS Applied Materials & Interfaces, 2018, v. 10 n. 28, p. 23700-23710-
dc.identifier.issn1944-8244-
dc.identifier.urihttp://hdl.handle.net/10722/278942-
dc.description.abstractStem cells are well-known for their great capacity for tissue regeneration. This provides a promising source for cell-based therapies in treating various bone degenerative disorders. However, the major hurdles for their application in transplantation are the poor bone marrow homing and engraftment efficiencies. Stromal cell-derived factor 1 (SDF-1) has been identified as a major stem cell homing factor. With the aims of bone targeted SDF-1 delivery and regulating MSCs migration, alendronate modified liposomal nanoparticles (Aln-Lipo) carrying SDF-1 gene were developed in this study. Alendronate modification significantly increased the mineral binding affinity of liposomes, and facilitated the gene delivery to osteoblastic cells. Up-regulated SDF-1 expression in osteoblasts triggered MSCs migration. Systemic infusion of Aln-Lipo-SDF-1 with fluorescence labeling in mice showed the accumulation in osseous tissue by biophotonic imaging. Corresponding to the delivered SDF-1, the transplanted GFP+ MSCs were attracted to bone marrow and contributed to bone regeneration. This study may provide a useful technique in regulating stem cell migration.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick-
dc.relation.ispartofACS Applied Materials & Interfaces-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectbone targeting-
dc.subjectgene delivery-
dc.subjectstem cell homing-
dc.subjectSDF-1-
dc.subjectosteoporosis therapy-
dc.titleBone Targeted Delivery of SDF-1 via Alendronate Functionalized Nanoparticles in Guiding Stem Cell Migration-
dc.typeArticle-
dc.identifier.emailLu, WW: wwlu@hku.hk-
dc.identifier.authorityLu, WW=rp00411-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsami.8b08606-
dc.identifier.pmid29939711-
dc.identifier.scopuseid_2-s2.0-85049247857-
dc.identifier.hkuros307541-
dc.identifier.volume10-
dc.identifier.issue28-
dc.identifier.spage23700-
dc.identifier.epage23710-
dc.publisher.placeUnited States-

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