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Article: Role of Regulatory T Cells in Noninherited Maternal Antigen-Related Tolerance in Cord Blood: An in Vitro Study

TitleRole of Regulatory T Cells in Noninherited Maternal Antigen-Related Tolerance in Cord Blood: An in Vitro Study
Authors
KeywordsCord blood transplantation
Human leukocyte antigen
Noninherited maternal antigen
Regulatory T cell
Alloimmune tolerance
Issue Date2019
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bbmt
Citation
Biology of Blood and Marrow Transplantation, 2019, v. 25 n. 3, p. 424-435 How to Cite?
AbstractCord blood (CB) is an alternative stem cell source for allogeneic hematopoietic stem cell transplantation (HSCT). The unique advantages of using CB as a stem cell source are a degree of permissibility for HLA mismatch, rapid availability, and relatively risk-free cell collection. Because HLA is highly polymorphic and population-specific, optimal HLA-matched unrelated donors or cord blood units (CBUs) might not be available. In view of the possibility that matched CBUs that include noninherited maternal antigens (NIMAs) might contain acceptable HLA mismatches, we attempted to determine the degree of alloreactivity of CB mononuclear cells (MNCs) on stimulation by the maternal, paternal, and unrelated stimulator cells. Suppression of T cell proliferation, cytotoxicity, and a cytokine profile indicating suppressed Th1 and elevated IL-10 and TGF-β1 responses were observed in the mixed lymphocyte reaction in response to NIMAs. The increases in IL-10 and TGF-β1 production may be due to the Th2 response and/or regulatory T cells (Tregs). The reduced IL-10 and TGF-β1 production after CD25 depletion could have been due to removal of Tregs from the CB cells. Thus, Tregs appear to play an important role in the CB MNC response to NIMAs, possibly due to the induction of IL-10 and TGF-β1. We hope that our work can provide some evidence of the beneficial effect of NIMAs.
Persistent Identifierhttp://hdl.handle.net/10722/279191
ISSN
2017 Impact Factor: 4.484
2015 SCImago Journal Rankings: 2.094

 

DC FieldValueLanguage
dc.contributor.authorKwok, J-
dc.contributor.authorChu, P-
dc.contributor.authorOng, C-
dc.contributor.authorLaw, HKW-
dc.contributor.authorIp, P-
dc.contributor.authorChan, GCF-
dc.contributor.authorLu, L-
dc.date.accessioned2019-10-21T02:21:17Z-
dc.date.available2019-10-21T02:21:17Z-
dc.date.issued2019-
dc.identifier.citationBiology of Blood and Marrow Transplantation, 2019, v. 25 n. 3, p. 424-435-
dc.identifier.issn1083-8791-
dc.identifier.urihttp://hdl.handle.net/10722/279191-
dc.description.abstractCord blood (CB) is an alternative stem cell source for allogeneic hematopoietic stem cell transplantation (HSCT). The unique advantages of using CB as a stem cell source are a degree of permissibility for HLA mismatch, rapid availability, and relatively risk-free cell collection. Because HLA is highly polymorphic and population-specific, optimal HLA-matched unrelated donors or cord blood units (CBUs) might not be available. In view of the possibility that matched CBUs that include noninherited maternal antigens (NIMAs) might contain acceptable HLA mismatches, we attempted to determine the degree of alloreactivity of CB mononuclear cells (MNCs) on stimulation by the maternal, paternal, and unrelated stimulator cells. Suppression of T cell proliferation, cytotoxicity, and a cytokine profile indicating suppressed Th1 and elevated IL-10 and TGF-β1 responses were observed in the mixed lymphocyte reaction in response to NIMAs. The increases in IL-10 and TGF-β1 production may be due to the Th2 response and/or regulatory T cells (Tregs). The reduced IL-10 and TGF-β1 production after CD25 depletion could have been due to removal of Tregs from the CB cells. Thus, Tregs appear to play an important role in the CB MNC response to NIMAs, possibly due to the induction of IL-10 and TGF-β1. We hope that our work can provide some evidence of the beneficial effect of NIMAs.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bbmt-
dc.relation.ispartofBiology of Blood and Marrow Transplantation-
dc.subjectCord blood transplantation-
dc.subjectHuman leukocyte antigen-
dc.subjectNoninherited maternal antigen-
dc.subjectRegulatory T cell-
dc.subjectAlloimmune tolerance-
dc.titleRole of Regulatory T Cells in Noninherited Maternal Antigen-Related Tolerance in Cord Blood: An in Vitro Study-
dc.typeArticle-
dc.identifier.emailKwok, J: kwoksy@hkucc.hku.hk-
dc.identifier.emailOng, C: cytong@hkucc.hku.hk-
dc.identifier.emailIp, P: patricip@hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.emailLu, L: liweilu@hku.hk-
dc.identifier.authorityOng, C=rp00482-
dc.identifier.authorityIp, P=rp01337-
dc.identifier.authorityChan, GCF=rp00431-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbmt.2018.10.021-
dc.identifier.pmid30412784-
dc.identifier.scopuseid_2-s2.0-85057256921-
dc.identifier.hkuros307253-
dc.identifier.volume25-
dc.identifier.issue3-
dc.identifier.spage424-
dc.identifier.epage435-
dc.publisher.placeUnited States-

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