File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.bbmt.2018.10.021
- Scopus: eid_2-s2.0-85057256921
- PMID: 30412784
- WOS: WOS:000465191400003
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Role of Regulatory T Cells in Noninherited Maternal Antigen-Related Tolerance in Cord Blood: An in Vitro Study
Title | Role of Regulatory T Cells in Noninherited Maternal Antigen-Related Tolerance in Cord Blood: An in Vitro Study |
---|---|
Authors | |
Keywords | Cord blood transplantation Human leukocyte antigen Noninherited maternal antigen Regulatory T cell Alloimmune tolerance |
Issue Date | 2019 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bbmt |
Citation | Biology of Blood and Marrow Transplantation, 2019, v. 25 n. 3, p. 424-435 How to Cite? |
Abstract | Cord blood (CB) is an alternative stem cell source for allogeneic hematopoietic stem cell transplantation (HSCT). The unique advantages of using CB as a stem cell source are a degree of permissibility for HLA mismatch, rapid availability, and relatively risk-free cell collection. Because HLA is highly polymorphic and population-specific, optimal HLA-matched unrelated donors or cord blood units (CBUs) might not be available. In view of the possibility that matched CBUs that include noninherited maternal antigens (NIMAs) might contain acceptable HLA mismatches, we attempted to determine the degree of alloreactivity of CB mononuclear cells (MNCs) on stimulation by the maternal, paternal, and unrelated stimulator cells. Suppression of T cell proliferation, cytotoxicity, and a cytokine profile indicating suppressed Th1 and elevated IL-10 and TGF-β1 responses were observed in the mixed lymphocyte reaction in response to NIMAs. The increases in IL-10 and TGF-β1 production may be due to the Th2 response and/or regulatory T cells (Tregs). The reduced IL-10 and TGF-β1 production after CD25 depletion could have been due to removal of Tregs from the CB cells. Thus, Tregs appear to play an important role in the CB MNC response to NIMAs, possibly due to the induction of IL-10 and TGF-β1. We hope that our work can provide some evidence of the beneficial effect of NIMAs. |
Persistent Identifier | http://hdl.handle.net/10722/279191 |
ISSN | 2022 Impact Factor: 4.3 2020 SCImago Journal Rankings: 2.301 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwok, J | - |
dc.contributor.author | Chu, P | - |
dc.contributor.author | Ong, C | - |
dc.contributor.author | Law, HKW | - |
dc.contributor.author | Ip, P | - |
dc.contributor.author | Chan, GCF | - |
dc.contributor.author | Lu, L | - |
dc.date.accessioned | 2019-10-21T02:21:17Z | - |
dc.date.available | 2019-10-21T02:21:17Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Biology of Blood and Marrow Transplantation, 2019, v. 25 n. 3, p. 424-435 | - |
dc.identifier.issn | 1083-8791 | - |
dc.identifier.uri | http://hdl.handle.net/10722/279191 | - |
dc.description.abstract | Cord blood (CB) is an alternative stem cell source for allogeneic hematopoietic stem cell transplantation (HSCT). The unique advantages of using CB as a stem cell source are a degree of permissibility for HLA mismatch, rapid availability, and relatively risk-free cell collection. Because HLA is highly polymorphic and population-specific, optimal HLA-matched unrelated donors or cord blood units (CBUs) might not be available. In view of the possibility that matched CBUs that include noninherited maternal antigens (NIMAs) might contain acceptable HLA mismatches, we attempted to determine the degree of alloreactivity of CB mononuclear cells (MNCs) on stimulation by the maternal, paternal, and unrelated stimulator cells. Suppression of T cell proliferation, cytotoxicity, and a cytokine profile indicating suppressed Th1 and elevated IL-10 and TGF-β1 responses were observed in the mixed lymphocyte reaction in response to NIMAs. The increases in IL-10 and TGF-β1 production may be due to the Th2 response and/or regulatory T cells (Tregs). The reduced IL-10 and TGF-β1 production after CD25 depletion could have been due to removal of Tregs from the CB cells. Thus, Tregs appear to play an important role in the CB MNC response to NIMAs, possibly due to the induction of IL-10 and TGF-β1. We hope that our work can provide some evidence of the beneficial effect of NIMAs. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bbmt | - |
dc.relation.ispartof | Biology of Blood and Marrow Transplantation | - |
dc.subject | Cord blood transplantation | - |
dc.subject | Human leukocyte antigen | - |
dc.subject | Noninherited maternal antigen | - |
dc.subject | Regulatory T cell | - |
dc.subject | Alloimmune tolerance | - |
dc.title | Role of Regulatory T Cells in Noninherited Maternal Antigen-Related Tolerance in Cord Blood: An in Vitro Study | - |
dc.type | Article | - |
dc.identifier.email | Kwok, J: kwoksy@hkucc.hku.hk | - |
dc.identifier.email | Ong, C: cytong@hkucc.hku.hk | - |
dc.identifier.email | Ip, P: patricip@hku.hk | - |
dc.identifier.email | Chan, GCF: gcfchan@hku.hk | - |
dc.identifier.email | Lu, L: liweilu@hku.hk | - |
dc.identifier.authority | Ong, C=rp00482 | - |
dc.identifier.authority | Ip, P=rp01337 | - |
dc.identifier.authority | Chan, GCF=rp00431 | - |
dc.identifier.authority | Lu, L=rp00477 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bbmt.2018.10.021 | - |
dc.identifier.pmid | 30412784 | - |
dc.identifier.scopus | eid_2-s2.0-85057256921 | - |
dc.identifier.hkuros | 307253 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 424 | - |
dc.identifier.epage | 435 | - |
dc.identifier.isi | WOS:000465191400003 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1083-8791 | - |