File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Randomized controlled trial of TDCS on cognition in 201 seniors with mild neurocognitive disorder

TitleRandomized controlled trial of TDCS on cognition in 201 seniors with mild neurocognitive disorder
Authors
KeywordsBrain
Prefrontal Cortex
Anodal transcranial
Issue Date2019
PublisherWiley Open Access: Creative Commons Attribution Non-Commercial No Derivatives. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2328-9503
Citation
Annals of Clinical and Translational Neurology, 2019, v. 6 n. 10, p. 1938-1948 How to Cite?
AbstractObjective: To examine the efficacy and safety of combined transcranial direct current stimulation (tDCS) and working memory training (WMT) in enhancing the cognitive functions for individuals with mild neurocognitive disorder due to AD (NCD‐AD). Methods: In this double‐blind, sham‐controlled randomized clinical trial (RCT), 201 patients with NCD‐AD were randomly assigned for a 4‐week intervention of either a combination of tDCS and WMT, sham tDCS and WMT, or tDCS and control cognitive training (CCT). Global cognition and domain‐specific cognitive function were assessed before and after the intervention with Alzheimer's disease assessment scale‐cognitive subscale (ADAS‐Cog), category verbal fluency test, logical memory, digit, and visual span tests. Results: Study participants did not show intervention group differences in baseline demographics, or cognitive characteristics (ANOVA). Cognitive enhancement was found across three groups after 4 weeks intervention. Combined tDCS‐WMT group showed significantly greater improvement compared with single‐modality groups in delayed recall (P = 0.043, η2 = 0.036) and working memory capacity (P = 0.04, η2 = 0.038) at 4th week, and logical memory at 12th week (P = 0.042, η2 = 0.037). Adverse events, including skin lesions (2.2%), were similar between groups. Interpretation: tDCS or WMT could be a safe, feasible, and effective intervention for individuals with NCD‐AD. A combination of tDCS and WMT presents greater cognitive enhancement, which may highlight the potential synergistic effects of combined modality intervention on cognition.
Persistent Identifierhttp://hdl.handle.net/10722/279197
ISSN
2019 Impact Factor: 3.66
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLu, H-
dc.contributor.authorChan, SSM-
dc.contributor.authorChan, WC-
dc.contributor.authorLin, C-
dc.contributor.authorCheng, CPW-
dc.contributor.authorLam, LCW-
dc.date.accessioned2019-10-21T02:21:23Z-
dc.date.available2019-10-21T02:21:23Z-
dc.date.issued2019-
dc.identifier.citationAnnals of Clinical and Translational Neurology, 2019, v. 6 n. 10, p. 1938-1948-
dc.identifier.issn2328-9503-
dc.identifier.urihttp://hdl.handle.net/10722/279197-
dc.description.abstractObjective: To examine the efficacy and safety of combined transcranial direct current stimulation (tDCS) and working memory training (WMT) in enhancing the cognitive functions for individuals with mild neurocognitive disorder due to AD (NCD‐AD). Methods: In this double‐blind, sham‐controlled randomized clinical trial (RCT), 201 patients with NCD‐AD were randomly assigned for a 4‐week intervention of either a combination of tDCS and WMT, sham tDCS and WMT, or tDCS and control cognitive training (CCT). Global cognition and domain‐specific cognitive function were assessed before and after the intervention with Alzheimer's disease assessment scale‐cognitive subscale (ADAS‐Cog), category verbal fluency test, logical memory, digit, and visual span tests. Results: Study participants did not show intervention group differences in baseline demographics, or cognitive characteristics (ANOVA). Cognitive enhancement was found across three groups after 4 weeks intervention. Combined tDCS‐WMT group showed significantly greater improvement compared with single‐modality groups in delayed recall (P = 0.043, η2 = 0.036) and working memory capacity (P = 0.04, η2 = 0.038) at 4th week, and logical memory at 12th week (P = 0.042, η2 = 0.037). Adverse events, including skin lesions (2.2%), were similar between groups. Interpretation: tDCS or WMT could be a safe, feasible, and effective intervention for individuals with NCD‐AD. A combination of tDCS and WMT presents greater cognitive enhancement, which may highlight the potential synergistic effects of combined modality intervention on cognition.-
dc.languageeng-
dc.publisherWiley Open Access: Creative Commons Attribution Non-Commercial No Derivatives. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2328-9503-
dc.relation.ispartofAnnals of Clinical and Translational Neurology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBrain-
dc.subjectPrefrontal Cortex-
dc.subjectAnodal transcranial-
dc.titleRandomized controlled trial of TDCS on cognition in 201 seniors with mild neurocognitive disorder-
dc.typeArticle-
dc.identifier.emailChan, WC: waicchan@hku.hk-
dc.identifier.emailCheng, CPW: chengpsy@hku.hk-
dc.identifier.authorityChan, WC=rp01687-
dc.identifier.authorityCheng, CPW=rp02333-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/acn3.50823-
dc.identifier.pmid31529691-
dc.identifier.pmcidPMC6801176-
dc.identifier.scopuseid_2-s2.0-85073597105-
dc.identifier.hkuros308002-
dc.identifier.volume6-
dc.identifier.issue10-
dc.identifier.spage1938-
dc.identifier.epage1948-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats