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Article: Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials
Title | Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials |
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Authors | |
Keywords | Alzheimer’s disease Multiple sclerosis Parkinson’s disease Depression Schizophrenia |
Issue Date | 2021 |
Publisher | Springer Verlag. The Journal's web site is located at http://www.springer.com/medicine/neurology/journal/415 |
Citation | Journal of Neurology, 2021, v. 268, p. 1222-1246 How to Cite? |
Abstract | We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms and cognition across six chronic brain disorders: Alzheimer’s disease, Huntington’s disease, multiple sclerosis, Parkinson’s disease, schizophrenia and unipolar depression. 122 studies ( = k) (n = 7231) were included. Exercise was superior to treatment as usual in improving QoL (k = 64, n = 4334, ES = 0.40, p < 0.0001), depressive symptoms (k = 60, n = 2909, ES = 0.78, p < 0.0001), the cognitive domains attention and working memory (k = 21, n = 1313, ES = 0.24, p < 0.009), executive functioning (k = 14, n = 977, ES = 0.15, p = 0.013), memory (k = 12, n = 994, ES = 0.12, p = 0.038) and psychomotor speed (k = 16, n = 896, ES = 0.23, p = 0.003). Meta-regression showed a dose–response effect for exercise time (min/week) on depressive symptoms (β = 0.007, p = 0.012). 69% of the studies that reported on safety, found no complications. Exercise is an efficacious and safe add-on therapeutic intervention showing a medium-sized effect on QoL and a large effect on mood in patients with chronic brain disorders, with a positive dose–response correlation. Exercise also improved several cognitive domains with small but significant effects. |
Persistent Identifier | http://hdl.handle.net/10722/279488 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 1.552 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Dauwan, M | - |
dc.contributor.author | Begemann, MJH | - |
dc.contributor.author | Slot, MIE | - |
dc.contributor.author | Lee, HME | - |
dc.contributor.author | Scheltens, P | - |
dc.contributor.author | Sommer, IEC | - |
dc.date.accessioned | 2019-11-01T07:18:20Z | - |
dc.date.available | 2019-11-01T07:18:20Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Neurology, 2021, v. 268, p. 1222-1246 | - |
dc.identifier.issn | 0340-5354 | - |
dc.identifier.uri | http://hdl.handle.net/10722/279488 | - |
dc.description.abstract | We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms and cognition across six chronic brain disorders: Alzheimer’s disease, Huntington’s disease, multiple sclerosis, Parkinson’s disease, schizophrenia and unipolar depression. 122 studies ( = k) (n = 7231) were included. Exercise was superior to treatment as usual in improving QoL (k = 64, n = 4334, ES = 0.40, p < 0.0001), depressive symptoms (k = 60, n = 2909, ES = 0.78, p < 0.0001), the cognitive domains attention and working memory (k = 21, n = 1313, ES = 0.24, p < 0.009), executive functioning (k = 14, n = 977, ES = 0.15, p = 0.013), memory (k = 12, n = 994, ES = 0.12, p = 0.038) and psychomotor speed (k = 16, n = 896, ES = 0.23, p = 0.003). Meta-regression showed a dose–response effect for exercise time (min/week) on depressive symptoms (β = 0.007, p = 0.012). 69% of the studies that reported on safety, found no complications. Exercise is an efficacious and safe add-on therapeutic intervention showing a medium-sized effect on QoL and a large effect on mood in patients with chronic brain disorders, with a positive dose–response correlation. Exercise also improved several cognitive domains with small but significant effects. | - |
dc.language | eng | - |
dc.publisher | Springer Verlag. The Journal's web site is located at http://www.springer.com/medicine/neurology/journal/415 | - |
dc.relation.ispartof | Journal of Neurology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Alzheimer’s disease | - |
dc.subject | Multiple sclerosis | - |
dc.subject | Parkinson’s disease | - |
dc.subject | Depression | - |
dc.subject | Schizophrenia | - |
dc.title | Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials | - |
dc.type | Article | - |
dc.identifier.email | Lee, HME: edwinlhm@hku.hk | - |
dc.identifier.authority | Lee, HME=rp01575 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1007/s00415-019-09493-9 | - |
dc.identifier.scopus | eid_2-s2.0-85070979476 | - |
dc.identifier.hkuros | 308343 | - |
dc.identifier.volume | 268 | - |
dc.identifier.spage | 1222 | - |
dc.identifier.epage | 1246 | - |
dc.identifier.isi | WOS:000632490100011 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 0340-5354 | - |