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- Publisher Website: 10.1016/j.euroneuro.2019.12.107
- Scopus: eid_2-s2.0-85077001176
- PMID: 31883653
- WOS: WOS:000510016600013
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Article: Mortality in patients with schizophrenia admitted for incident ischemic stroke: A population-based cohort study
Title | Mortality in patients with schizophrenia admitted for incident ischemic stroke: A population-based cohort study |
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Authors | |
Keywords | Ischemic stroke Mortality Population-based study Schizophrenia Stroke |
Issue Date | 2020 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/euroneuro |
Citation | European Neuropsychopharmacology, 2020, v. 31, p. 152-157 How to Cite? |
Abstract | Evidence shows that schizophrenia is associated with increased incidence of stroke. However, relationship between schizophrenia and short-term mortality risk is understudied, and mixed findings were observed. In this retrospective population-based cohort study, we identified individuals admitted for incident ischemic stroke between 2006 and 2016 using a territory-wide electronic medical record database of public healthcare system in Hong Kong to examine 30-day and 1-year mortality rates in 817 schizophrenia patients compared with 8170 patients without psychotic disorder (10:1 matched to schizophrenia patients on demographics, treatment sites and calendar-period for index admission). Multivariate regression analyses adjusting for medical comorbidities revealed that schizophrenia patients experienced elevated 1-year (16.9% vs 12.1%; p < 0.001) and 30-day mortality (7.2% vs 5.3%; p = 0.053) relative to control group. Additional age- and gender-stratified analyses revealed even more pronounced effect of schizophrenia on raised mortality risk, as indicated by higher odds, in younger-age (<65 years) group and men. Our results indicate that schizophrenia is associated with heightened short-term mortality following incident ischemic stroke. Further research is warranted to identify factors contributing to excess post-stroke deaths among schizophrenia patients to facilitate development of effective interventions for mortality risk reduction. |
Persistent Identifier | http://hdl.handle.net/10722/280388 |
ISSN | 2023 Impact Factor: 6.1 2023 SCImago Journal Rankings: 1.756 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yung, NCL | - |
dc.contributor.author | Wong, CSM | - |
dc.contributor.author | Chan, JKN | - |
dc.contributor.author | Or, PCF | - |
dc.contributor.author | Chen, EYH | - |
dc.contributor.author | Chang, WC | - |
dc.date.accessioned | 2020-02-07T07:40:18Z | - |
dc.date.available | 2020-02-07T07:40:18Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | European Neuropsychopharmacology, 2020, v. 31, p. 152-157 | - |
dc.identifier.issn | 0924-977X | - |
dc.identifier.uri | http://hdl.handle.net/10722/280388 | - |
dc.description.abstract | Evidence shows that schizophrenia is associated with increased incidence of stroke. However, relationship between schizophrenia and short-term mortality risk is understudied, and mixed findings were observed. In this retrospective population-based cohort study, we identified individuals admitted for incident ischemic stroke between 2006 and 2016 using a territory-wide electronic medical record database of public healthcare system in Hong Kong to examine 30-day and 1-year mortality rates in 817 schizophrenia patients compared with 8170 patients without psychotic disorder (10:1 matched to schizophrenia patients on demographics, treatment sites and calendar-period for index admission). Multivariate regression analyses adjusting for medical comorbidities revealed that schizophrenia patients experienced elevated 1-year (16.9% vs 12.1%; p < 0.001) and 30-day mortality (7.2% vs 5.3%; p = 0.053) relative to control group. Additional age- and gender-stratified analyses revealed even more pronounced effect of schizophrenia on raised mortality risk, as indicated by higher odds, in younger-age (<65 years) group and men. Our results indicate that schizophrenia is associated with heightened short-term mortality following incident ischemic stroke. Further research is warranted to identify factors contributing to excess post-stroke deaths among schizophrenia patients to facilitate development of effective interventions for mortality risk reduction. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/euroneuro | - |
dc.relation.ispartof | European Neuropsychopharmacology | - |
dc.subject | Ischemic stroke | - |
dc.subject | Mortality | - |
dc.subject | Population-based study | - |
dc.subject | Schizophrenia | - |
dc.subject | Stroke | - |
dc.title | Mortality in patients with schizophrenia admitted for incident ischemic stroke: A population-based cohort study | - |
dc.type | Article | - |
dc.identifier.email | Wong, CSM: wongcsm@hku.hk | - |
dc.identifier.email | Chan, JKN: kwunnam@hku.hk | - |
dc.identifier.email | Chen, EYH: eyhchen@hku.hk | - |
dc.identifier.email | Chang, WC: changwc@hku.hk | - |
dc.identifier.authority | Wong, CSM=rp02625 | - |
dc.identifier.authority | Chen, EYH=rp00392 | - |
dc.identifier.authority | Chang, WC=rp01465 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.euroneuro.2019.12.107 | - |
dc.identifier.pmid | 31883653 | - |
dc.identifier.scopus | eid_2-s2.0-85077001176 | - |
dc.identifier.hkuros | 309122 | - |
dc.identifier.hkuros | 316159 | - |
dc.identifier.volume | 31 | - |
dc.identifier.spage | 152 | - |
dc.identifier.epage | 157 | - |
dc.identifier.isi | WOS:000510016600013 | - |
dc.publisher.place | Netherlands | - |
dc.identifier.issnl | 0924-977X | - |