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Article: Age of puberty and sleep duration: observational and mendelian randomization study

TitleAge of puberty and sleep duration: observational and mendelian randomization study
Authors
KeywordsMenarche
Puberty
Menarcheal age
Issue Date2020
PublisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2020, v. 10 n. 1, p. article no. 3202 How to Cite?
AbstractEarlier age of puberty has detrimental consequences for many aspects of health. Here, for the first time, we assessed the association of earlier puberty with sleep duration observationally and with validation using Mendelian Randomization. In the “Children of 1997” birth cohort (n = 8,327), we used adjusted multivariable logistic regression to assess the associations of each clinically assessed marker of earlier puberty with self-report sleep duration in adolescence. Using two-sample MR, we assessed the effect of earlier puberty timing based on 203 single nucleotide polymorphisms applied to genome wide association studies of sleep duration in adults (n = 335,410). In “Children of 1997”, cross-sectionally, older age of menarche was associated with longer (9+ hours) sleep duration [odds ratio (OR) 1.11, 95% confidence interval (CI) 1.01 to 1.21] at 13.5 years. The other earlier puberty markers were unrelated to sleep duration. Using inverse variance weighting, later of age at menarche increased adult sleep duration [0.020 per category, 95% CI 0.006 to 0.034]. This study demonstrated a causal effect of age at menarche on adult sleep duration, since age of menarche also affects obesity, our novel finding may be relevant to the observed relation of sleep duration with obesity and poor health.
Persistent Identifierhttp://hdl.handle.net/10722/281155
ISSN
2019 Impact Factor: 3.998
2015 SCImago Journal Rankings: 2.073

 

DC FieldValueLanguage
dc.contributor.authorWANG, J-
dc.contributor.authorKwok, MK-
dc.contributor.authorAu Yeung, SL-
dc.contributor.authorZhao, J-
dc.contributor.authorLi, AM-
dc.contributor.authorLam, HS-
dc.contributor.authorLeung, GM-
dc.contributor.authorSchooling, CM-
dc.date.accessioned2020-03-09T09:50:55Z-
dc.date.available2020-03-09T09:50:55Z-
dc.date.issued2020-
dc.identifier.citationScientific Reports, 2020, v. 10 n. 1, p. article no. 3202-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/281155-
dc.description.abstractEarlier age of puberty has detrimental consequences for many aspects of health. Here, for the first time, we assessed the association of earlier puberty with sleep duration observationally and with validation using Mendelian Randomization. In the “Children of 1997” birth cohort (n = 8,327), we used adjusted multivariable logistic regression to assess the associations of each clinically assessed marker of earlier puberty with self-report sleep duration in adolescence. Using two-sample MR, we assessed the effect of earlier puberty timing based on 203 single nucleotide polymorphisms applied to genome wide association studies of sleep duration in adults (n = 335,410). In “Children of 1997”, cross-sectionally, older age of menarche was associated with longer (9+ hours) sleep duration [odds ratio (OR) 1.11, 95% confidence interval (CI) 1.01 to 1.21] at 13.5 years. The other earlier puberty markers were unrelated to sleep duration. Using inverse variance weighting, later of age at menarche increased adult sleep duration [0.020 per category, 95% CI 0.006 to 0.034]. This study demonstrated a causal effect of age at menarche on adult sleep duration, since age of menarche also affects obesity, our novel finding may be relevant to the observed relation of sleep duration with obesity and poor health.-
dc.languageeng-
dc.publisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectMenarche-
dc.subjectPuberty-
dc.subjectMenarcheal age-
dc.titleAge of puberty and sleep duration: observational and mendelian randomization study-
dc.typeArticle-
dc.identifier.emailKwok, MK: maggiek@hku.hk-
dc.identifier.emailAu Yeung, SL: ayslryan@hku.hk-
dc.identifier.emailZhao, J: janezhao@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hk-
dc.identifier.authorityKwok, MK=rp02051-
dc.identifier.authorityAu Yeung, SL=rp02224-
dc.identifier.authorityZhao, J=rp02336-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authoritySchooling, CM=rp00504-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-020-59811-9-
dc.identifier.pmid32081851-
dc.identifier.scopuseid_2-s2.0-85079762649-
dc.identifier.hkuros309301-
dc.identifier.volume10-
dc.identifier.issue1-
dc.identifier.spagearticle no. 3202-
dc.identifier.epagearticle no. 3202-
dc.publisher.placeUnited Kingdom-

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