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Article: Therapeutic potential of Hericium erinaceus for depressive disorder

TitleTherapeutic potential of Hericium erinaceus for depressive disorder
Authors
KeywordsHericium erinaceus
Lion’s mane mushroom
depression
antidepressant
mood disorders
Issue Date2020
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2020, v. 21 n. 1, p. article no. 163 How to Cite?
AbstractDepression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects. Hericium erinaceus, also known as Lion’s mane mushroom, has been shown to have various health benefits, including antioxidative, antidiabetic, anticancer, anti-inflammatory, antimicrobial, antihyperglycemic, and hypolipidemic effects. It has been used to treat cognitive impairment, Parkinson’s disease, and Alzheimer’s disease. Bioactive compounds extracted from the mycelia and fruiting bodies of H. erinaceus have been found to promote the expression of neurotrophic factors that are associated with cell proliferation such as nerve growth factors. Although antidepressant effects of H. erinaceus have not been validated and compared to the conventional antidepressants, based on the neurotrophic and neurogenic pathophysiology of depression, H. erinaceus may be a potential alternative medicine for the treatment of depression. This article critically reviews the current literature on the potential benefits of H. erinaceus as a treatment for depressive disorder as well as its mechanisms underlying the antidepressant-like activities. View Full-Text Keywords:
Persistent Identifierhttp://hdl.handle.net/10722/281169
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChong, PS-
dc.contributor.authorFung, ML-
dc.contributor.authorWong, KH-
dc.contributor.authorLim, LW-
dc.date.accessioned2020-03-09T09:51:06Z-
dc.date.available2020-03-09T09:51:06Z-
dc.date.issued2020-
dc.identifier.citationInternational Journal of Molecular Sciences, 2020, v. 21 n. 1, p. article no. 163-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/281169-
dc.description.abstractDepression is a common and severe neuropsychiatric disorder that is one of the leading causes of global disease burden. Although various anti-depressants are currently available, their efficacies are barely adequate and many have side effects. Hericium erinaceus, also known as Lion’s mane mushroom, has been shown to have various health benefits, including antioxidative, antidiabetic, anticancer, anti-inflammatory, antimicrobial, antihyperglycemic, and hypolipidemic effects. It has been used to treat cognitive impairment, Parkinson’s disease, and Alzheimer’s disease. Bioactive compounds extracted from the mycelia and fruiting bodies of H. erinaceus have been found to promote the expression of neurotrophic factors that are associated with cell proliferation such as nerve growth factors. Although antidepressant effects of H. erinaceus have not been validated and compared to the conventional antidepressants, based on the neurotrophic and neurogenic pathophysiology of depression, H. erinaceus may be a potential alternative medicine for the treatment of depression. This article critically reviews the current literature on the potential benefits of H. erinaceus as a treatment for depressive disorder as well as its mechanisms underlying the antidepressant-like activities. View Full-Text Keywords:-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHericium erinaceus-
dc.subjectLion’s mane mushroom-
dc.subjectdepression-
dc.subjectantidepressant-
dc.subjectmood disorders-
dc.titleTherapeutic potential of Hericium erinaceus for depressive disorder-
dc.typeArticle-
dc.identifier.emailFung, M-L: fungml@hku.hk-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityFung, M-L=rp00433-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms21010163-
dc.identifier.pmid31881712-
dc.identifier.pmcidPMC6982118-
dc.identifier.scopuseid_2-s2.0-85077285830-
dc.identifier.hkuros309282-
dc.identifier.hkuros316111-
dc.identifier.volume21-
dc.identifier.issue1-
dc.identifier.spagearticle no. 163-
dc.identifier.epagearticle no. 163-
dc.identifier.isiWOS:000515378000163-
dc.publisher.placeSwitzerland-
dc.identifier.issnl1422-0067-

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