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Article: Mechanical and biological properties of Ti–(0–25 wt%)Nb alloys for biomedical implants application

TitleMechanical and biological properties of Ti–(0–25 wt%)Nb alloys for biomedical implants application
Authors
Keywordsbiomaterial
titanium–niobium
binary titanium alloys
low Young’s modulus
biocompatibility
Issue Date2020
PublisherOxford University Press (OUP): Policy C - Option A. The Journal's web site is located at http://rb.oxfordjournals.org/
Citation
Regenerative Biomaterials, 2020, v. 7, p. 119-127 How to Cite?
AbstractBinary titanium–niobium (Ti–Nb) alloys have recently been attracted due to low Young’s moduli and non-toxic properties. This study explores the influence of low Nb content (0–25 wt%) on the comprehensive parameters of tensile stress–strain relationships (ultimate strength (σUTS), yield strength (σ0.2) and elastic modulus (E)), surfaces properties (Vickers microhardness, surface roughness (Ra), water contact angle (WCA), X-ray diffraction (XRD) and scanning electron microscopy (SEM)), corrosion resistance (in artificial saliva and lactic acid) and biological properties (cytotoxicity and alkaline phosphatase activity of MC3T3-E1 pre-osteoblasts) of Ti–xNb alloys (x = 5, 10, 15, 20 and 25 wt%), with using commercially pure grade 2 titanium (cp-Ti) as control. XRD results shown that all the Ti–xNb alloys comprised α + β Ti alloy phases, such that the β phase increased correspondingly with the increased amount of Nb in the alloy, as well as the reduction of E (69–87 GPa). Except Ti–5Nb, all other Ti–xNb alloys showed a significantly higher hardness, increased σUTS and σ0.2, and decreased WCA compared with cp-Ti. No corrosion was detected on Ti–xNb alloys and cp-Ti in artificial saliva and lactic acid solutions. The cytotoxicity of Ti–xNb alloys was comparable to that of cp-Ti in MC3T3-E1 pre-osteoblasts without interference from differentiation behaviour, but the proliferation rate of the Ti–5Nb alloy was lower than other groups. In overall, binary Ti–(10–25 wt%)Nb alloys are promising candidate for orthopaedic and dental implants due to their improved mechanical properties and comparable biological performance, while Ti–5Nb should be used with caution.
Descriptioneid_2-s2.0-85082038859
Persistent Identifierhttp://hdl.handle.net/10722/281792
ISSN
2019 Impact Factor: 4.882

 

DC FieldValueLanguage
dc.contributor.authorZhang, Y-
dc.contributor.authorSun, D-
dc.contributor.authorCheng, J-
dc.contributor.authorTsoi, KH-
dc.contributor.authorChen, J-
dc.date.accessioned2020-03-27T04:22:34Z-
dc.date.available2020-03-27T04:22:34Z-
dc.date.issued2020-
dc.identifier.citationRegenerative Biomaterials, 2020, v. 7, p. 119-127-
dc.identifier.issn2056-3418-
dc.identifier.urihttp://hdl.handle.net/10722/281792-
dc.descriptioneid_2-s2.0-85082038859-
dc.description.abstractBinary titanium–niobium (Ti–Nb) alloys have recently been attracted due to low Young’s moduli and non-toxic properties. This study explores the influence of low Nb content (0–25 wt%) on the comprehensive parameters of tensile stress–strain relationships (ultimate strength (σUTS), yield strength (σ0.2) and elastic modulus (E)), surfaces properties (Vickers microhardness, surface roughness (Ra), water contact angle (WCA), X-ray diffraction (XRD) and scanning electron microscopy (SEM)), corrosion resistance (in artificial saliva and lactic acid) and biological properties (cytotoxicity and alkaline phosphatase activity of MC3T3-E1 pre-osteoblasts) of Ti–xNb alloys (x = 5, 10, 15, 20 and 25 wt%), with using commercially pure grade 2 titanium (cp-Ti) as control. XRD results shown that all the Ti–xNb alloys comprised α + β Ti alloy phases, such that the β phase increased correspondingly with the increased amount of Nb in the alloy, as well as the reduction of E (69–87 GPa). Except Ti–5Nb, all other Ti–xNb alloys showed a significantly higher hardness, increased σUTS and σ0.2, and decreased WCA compared with cp-Ti. No corrosion was detected on Ti–xNb alloys and cp-Ti in artificial saliva and lactic acid solutions. The cytotoxicity of Ti–xNb alloys was comparable to that of cp-Ti in MC3T3-E1 pre-osteoblasts without interference from differentiation behaviour, but the proliferation rate of the Ti–5Nb alloy was lower than other groups. In overall, binary Ti–(10–25 wt%)Nb alloys are promising candidate for orthopaedic and dental implants due to their improved mechanical properties and comparable biological performance, while Ti–5Nb should be used with caution.-
dc.languageeng-
dc.publisherOxford University Press (OUP): Policy C - Option A. The Journal's web site is located at http://rb.oxfordjournals.org/-
dc.relation.ispartofRegenerative Biomaterials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbiomaterial-
dc.subjecttitanium–niobium-
dc.subjectbinary titanium alloys-
dc.subjectlow Young’s modulus-
dc.subjectbiocompatibility-
dc.titleMechanical and biological properties of Ti–(0–25 wt%)Nb alloys for biomedical implants application-
dc.typeArticle-
dc.identifier.emailTsoi, KH: jkhtsoi@hku.hk-
dc.identifier.authorityTsoi, KH=rp01609-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/rb/rbz042-
dc.identifier.scopuseid_2-s2.0-85082038859-
dc.identifier.hkuros309538-
dc.identifier.volume7-
dc.identifier.spage119-
dc.identifier.epage127-
dc.publisher.placeUnited Kingdom-

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