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Article: Mechanical and biological properties of Ti–(0–25 wt%)Nb alloys for biomedical implants application
Title | Mechanical and biological properties of Ti–(0–25 wt%)Nb alloys for biomedical implants application |
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Authors | |
Keywords | biomaterial titanium–niobium binary titanium alloys low Young’s modulus biocompatibility |
Issue Date | 2020 |
Publisher | Oxford University Press (OUP): Policy C - Option A. The Journal's web site is located at http://rb.oxfordjournals.org/ |
Citation | Regenerative Biomaterials, 2020, v. 7, p. 119-127 How to Cite? |
Abstract | Binary titanium–niobium (Ti–Nb) alloys have recently been attracted due to low Young’s moduli and non-toxic properties. This study explores the influence of low Nb content (0–25 wt%) on the comprehensive parameters of tensile stress–strain relationships (ultimate strength (σUTS), yield strength (σ0.2) and elastic modulus (E)), surfaces properties (Vickers microhardness, surface roughness (Ra), water contact angle (WCA), X-ray diffraction (XRD) and scanning electron microscopy (SEM)), corrosion resistance (in artificial saliva and lactic acid) and biological properties (cytotoxicity and alkaline phosphatase activity of MC3T3-E1 pre-osteoblasts) of Ti–xNb alloys (x = 5, 10, 15, 20 and 25 wt%), with using commercially pure grade 2 titanium (cp-Ti) as control. XRD results shown that all the Ti–xNb alloys comprised α + β Ti alloy phases, such that the β phase increased correspondingly with the increased amount of Nb in the alloy, as well as the reduction of E (69–87 GPa). Except Ti–5Nb, all other Ti–xNb alloys showed a significantly higher hardness, increased σUTS and σ0.2, and decreased WCA compared with cp-Ti. No corrosion was detected on Ti–xNb alloys and cp-Ti in artificial saliva and lactic acid solutions. The cytotoxicity of Ti–xNb alloys was comparable to that of cp-Ti in MC3T3-E1 pre-osteoblasts without interference from differentiation behaviour, but the proliferation rate of the Ti–5Nb alloy was lower than other groups. In overall, binary Ti–(10–25 wt%)Nb alloys are promising candidate for orthopaedic and dental implants due to their improved mechanical properties and comparable biological performance, while Ti–5Nb should be used with caution. |
Description | eid_2-s2.0-85082038859 |
Persistent Identifier | http://hdl.handle.net/10722/281792 |
ISSN | 2021 Impact Factor: 5.763 2020 SCImago Journal Rankings: 1.166 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhang, Y | - |
dc.contributor.author | Sun, D | - |
dc.contributor.author | Cheng, J | - |
dc.contributor.author | Tsoi, KH | - |
dc.contributor.author | Chen, J | - |
dc.date.accessioned | 2020-03-27T04:22:34Z | - |
dc.date.available | 2020-03-27T04:22:34Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Regenerative Biomaterials, 2020, v. 7, p. 119-127 | - |
dc.identifier.issn | 2056-3418 | - |
dc.identifier.uri | http://hdl.handle.net/10722/281792 | - |
dc.description | eid_2-s2.0-85082038859 | - |
dc.description.abstract | Binary titanium–niobium (Ti–Nb) alloys have recently been attracted due to low Young’s moduli and non-toxic properties. This study explores the influence of low Nb content (0–25 wt%) on the comprehensive parameters of tensile stress–strain relationships (ultimate strength (σUTS), yield strength (σ0.2) and elastic modulus (E)), surfaces properties (Vickers microhardness, surface roughness (Ra), water contact angle (WCA), X-ray diffraction (XRD) and scanning electron microscopy (SEM)), corrosion resistance (in artificial saliva and lactic acid) and biological properties (cytotoxicity and alkaline phosphatase activity of MC3T3-E1 pre-osteoblasts) of Ti–xNb alloys (x = 5, 10, 15, 20 and 25 wt%), with using commercially pure grade 2 titanium (cp-Ti) as control. XRD results shown that all the Ti–xNb alloys comprised α + β Ti alloy phases, such that the β phase increased correspondingly with the increased amount of Nb in the alloy, as well as the reduction of E (69–87 GPa). Except Ti–5Nb, all other Ti–xNb alloys showed a significantly higher hardness, increased σUTS and σ0.2, and decreased WCA compared with cp-Ti. No corrosion was detected on Ti–xNb alloys and cp-Ti in artificial saliva and lactic acid solutions. The cytotoxicity of Ti–xNb alloys was comparable to that of cp-Ti in MC3T3-E1 pre-osteoblasts without interference from differentiation behaviour, but the proliferation rate of the Ti–5Nb alloy was lower than other groups. In overall, binary Ti–(10–25 wt%)Nb alloys are promising candidate for orthopaedic and dental implants due to their improved mechanical properties and comparable biological performance, while Ti–5Nb should be used with caution. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press (OUP): Policy C - Option A. The Journal's web site is located at http://rb.oxfordjournals.org/ | - |
dc.relation.ispartof | Regenerative Biomaterials | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | biomaterial | - |
dc.subject | titanium–niobium | - |
dc.subject | binary titanium alloys | - |
dc.subject | low Young’s modulus | - |
dc.subject | biocompatibility | - |
dc.title | Mechanical and biological properties of Ti–(0–25 wt%)Nb alloys for biomedical implants application | - |
dc.type | Article | - |
dc.identifier.email | Tsoi, KH: jkhtsoi@hku.hk | - |
dc.identifier.authority | Tsoi, KH=rp01609 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1093/rb/rbz042 | - |
dc.identifier.scopus | eid_2-s2.0-85082038859 | - |
dc.identifier.hkuros | 309538 | - |
dc.identifier.volume | 7 | - |
dc.identifier.spage | 119 | - |
dc.identifier.epage | 127 | - |
dc.identifier.isi | WOS:000569529300014 | - |
dc.publisher.place | United Kingdom | - |