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Article: Is kidney function associated with primary open-angle glaucoma? Findings from the Asian Eye Epidemiology Consortium

TitleIs kidney function associated with primary open-angle glaucoma? Findings from the Asian Eye Epidemiology Consortium
Authors
Keywordsepidemiology
glaucoma
Issue Date2020
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal of Ophthalmology, 2020, Epub 2020-01-20, p. article no. 314890 How to Cite?
AbstractAIM: To comprehensively examine the association between kidney function and primary open angle glaucoma (POAG) in a large consortium of multiple Asian population-based studies. METHODS: 28 925 participants (57 340 eyes) from 9 population-based studies (from China, Hong Kong, India, Korea, Russia, Singapore) of the Asian Eye Epidemiology Consortium were included. Across all studies, POAG was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine. Chronic kidney disease (CKD) was defined as eGFR<60 mL/min/1.73 m(2). Eye-specific data were pooled from each study. Multivariable regression analysis with generalised estimating equation models was performed to evaluate the associations between kidney function with POAG and intraocular pressure (IOP). RESULTS: After adjusting for age, gender, study group, hypertension, diabetes, hyperlipidaemia, body mass index, smoking status and IOP, lower eGFR (per 10 mL/min/1.73 m(2) decrease) was not significantly associated with POAG (OR=1.01; p=0.77). Presence of CKD was also not significantly associated with POAG (OR=1.01; p=0.739). Furthermore, lower eGFR and presence of CKD were not associated with IOP (all p>/=0.12), However, in the subgroup of combined Korean and Chinese individuals, significant associations between lower eGFR (OR=1.09; 95% CI 1.00 to 1.18; p=0.048) and severe kidney function decline (<45 mL/min/1.73 m(2); OR=2.57; 95% CI 1.34 to 4.93; p=0.004) with POAG, were observed. CONCLUSION: In this large pooled-analysis of multiple Asian population-based studies, our findings suggest that the association between CKD and POAG may only be present in East Asians specifically but not in the overall Asian population. Further evaluation in Japanese population is warranted to confirm this observation.
Persistent Identifierhttp://hdl.handle.net/10722/281919
ISSN
2019 Impact Factor: 3.611
2015 SCImago Journal Rankings: 1.873

 

DC FieldValueLanguage
dc.contributor.authorTham, Y-C-
dc.contributor.authorTao, Y-
dc.contributor.authorZhang, L-
dc.contributor.authorRim, THT-
dc.contributor.authorThakur, S-
dc.contributor.authorLim, ZW-
dc.contributor.authorChee, ML-
dc.contributor.authorBikbov, MM-
dc.contributor.authorKazakbaeva, GM-
dc.contributor.authorWang, N-
dc.contributor.authorCao, K-
dc.contributor.authorHao, J-
dc.contributor.authorNangia, V-
dc.contributor.authorPanda-Jonas, S-
dc.contributor.authorWang, YX-
dc.contributor.authorWong, IY-
dc.contributor.authorChan, JCH-
dc.contributor.authorMeng, Q-
dc.contributor.authorSabanayagam, C-
dc.contributor.authorWong, TY-
dc.contributor.authorJonas, JB-
dc.contributor.authorZhong, H-
dc.contributor.authorCheng, C-Y-
dc.contributor.authorAsian Eye Epidemiology Consortium (AEEC)-
dc.date.accessioned2020-04-03T07:23:38Z-
dc.date.available2020-04-03T07:23:38Z-
dc.date.issued2020-
dc.identifier.citationBritish Journal of Ophthalmology, 2020, Epub 2020-01-20, p. article no. 314890-
dc.identifier.issn0007-1161-
dc.identifier.urihttp://hdl.handle.net/10722/281919-
dc.description.abstractAIM: To comprehensively examine the association between kidney function and primary open angle glaucoma (POAG) in a large consortium of multiple Asian population-based studies. METHODS: 28 925 participants (57 340 eyes) from 9 population-based studies (from China, Hong Kong, India, Korea, Russia, Singapore) of the Asian Eye Epidemiology Consortium were included. Across all studies, POAG was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine. Chronic kidney disease (CKD) was defined as eGFR<60 mL/min/1.73 m(2). Eye-specific data were pooled from each study. Multivariable regression analysis with generalised estimating equation models was performed to evaluate the associations between kidney function with POAG and intraocular pressure (IOP). RESULTS: After adjusting for age, gender, study group, hypertension, diabetes, hyperlipidaemia, body mass index, smoking status and IOP, lower eGFR (per 10 mL/min/1.73 m(2) decrease) was not significantly associated with POAG (OR=1.01; p=0.77). Presence of CKD was also not significantly associated with POAG (OR=1.01; p=0.739). Furthermore, lower eGFR and presence of CKD were not associated with IOP (all p>/=0.12), However, in the subgroup of combined Korean and Chinese individuals, significant associations between lower eGFR (OR=1.09; 95% CI 1.00 to 1.18; p=0.048) and severe kidney function decline (<45 mL/min/1.73 m(2); OR=2.57; 95% CI 1.34 to 4.93; p=0.004) with POAG, were observed. CONCLUSION: In this large pooled-analysis of multiple Asian population-based studies, our findings suggest that the association between CKD and POAG may only be present in East Asians specifically but not in the overall Asian population. Further evaluation in Japanese population is warranted to confirm this observation.-
dc.languageeng-
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/-
dc.relation.ispartofBritish Journal of Ophthalmology-
dc.rightsBritish Journal of Ophthalmology. Copyright © BMJ Publishing Group.-
dc.rightsThis article has been accepted for publication in [Journal, Year] following peer review, and the Version of Record can be accessed online at [insert full DOI eg. http://dx.doi.org/10.1136/xxxxx]. [© Authors (or their employer(s)) OR © BMJ Publishing Group Ltd ( for assignments of BMJ Case Reports)] <year>-
dc.subjectepidemiology-
dc.subjectglaucoma-
dc.titleIs kidney function associated with primary open-angle glaucoma? Findings from the Asian Eye Epidemiology Consortium-
dc.typeArticle-
dc.identifier.emailWong, IY: wongyhi@hku.hk-
dc.identifier.emailChan, JCH: jonochan@hku.hk-
dc.identifier.authorityWong, IY=rp01467-
dc.identifier.authorityChan, JCH=rp02113-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1136/bjophthalmol-2019-314890-
dc.identifier.pmid31959588-
dc.identifier.scopuseid_2-s2.0-85079152524-
dc.identifier.hkuros309598-
dc.identifier.volumeEpub 2020-01-20-
dc.identifier.spagearticle no. 314890-
dc.identifier.epagearticle no. 314890-
dc.publisher.placeUnited Kingdom-
dc.identifier.f1000737245576-

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