File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Conference Paper: Pacemaker in the aged brain: From molecular profiling to memory enhancement

TitlePacemaker in the aged brain: From molecular profiling to memory enhancement
Authors
KeywordsElectrical Stimulation
Entorhinal
Perifornical
Ageing
Dementia
Issue Date2019
PublisherElsevier Inc. The Journal's web site is located at http://brainstimjrnl.com
Citation
3rd International Brain Stimulation Conference, Vancouver, Canada, 24-27 February 2019. Conference Abstracts in Brain Stimulation, 2019, v. 12 n. 2, p. 435, abstract no. 476 How to Cite?
AbstractAgeing is a major predicting risk factor for dementia and no treatment is currently available for this disorder. Although promising outcome has been reported for electrical stimulation on dementia, the molecular mechanisms still remain obscure. In an aged rat model, our results demonstrate that both entorhinal and perifornical stimulation enhanced spatial memory in the Morris water-maze without affecting anxiety levels. The microarray profiling showed a total of 1514 and 321 coding genes differentially expressed in the hippocampus, with a distinct pattern of signaling mechanisms involving the neurotransmission and neuroplasticity-related functions of entorhinal and perifornical stimulation, respectively. These results were further supported by protein changes associated with neurotransmission and neuroplasticity markers measured by western-blotting, mass-spectrometry, and FACS-based methods. Our present study identified a broad range of molecular pathways involved in the entorhinal and perifornical stimulation-induced memory enhancement, which could potentially be a promising therapeutic strategy for dementia.
DescriptionSession: Fast Track Symposium session 2e: Brain stimulation using depth and transc:ranlal electrodes: Use in neuropsyc:hiatry, modellng and validation - no. FS2e.04
Persistent Identifierhttp://hdl.handle.net/10722/282158
ISSN
2019 Impact Factor: 6.565
2015 SCImago Journal Rankings: 2.446

 

DC FieldValueLanguage
dc.contributor.authorKoh, J-
dc.contributor.authorLim, WL-
dc.contributor.authorNeoh, J-
dc.contributor.authorHescham, S-
dc.contributor.authorBlokland, A-
dc.contributor.authorChan, YS-
dc.contributor.authorTemel, Y-
dc.contributor.authorLim, LW-
dc.contributor.authorWu, EX-
dc.date.accessioned2020-05-05T03:37:50Z-
dc.date.available2020-05-05T03:37:50Z-
dc.date.issued2019-
dc.identifier.citation3rd International Brain Stimulation Conference, Vancouver, Canada, 24-27 February 2019. Conference Abstracts in Brain Stimulation, 2019, v. 12 n. 2, p. 435, abstract no. 476-
dc.identifier.issn1935-861X-
dc.identifier.urihttp://hdl.handle.net/10722/282158-
dc.descriptionSession: Fast Track Symposium session 2e: Brain stimulation using depth and transc:ranlal electrodes: Use in neuropsyc:hiatry, modellng and validation - no. FS2e.04-
dc.description.abstractAgeing is a major predicting risk factor for dementia and no treatment is currently available for this disorder. Although promising outcome has been reported for electrical stimulation on dementia, the molecular mechanisms still remain obscure. In an aged rat model, our results demonstrate that both entorhinal and perifornical stimulation enhanced spatial memory in the Morris water-maze without affecting anxiety levels. The microarray profiling showed a total of 1514 and 321 coding genes differentially expressed in the hippocampus, with a distinct pattern of signaling mechanisms involving the neurotransmission and neuroplasticity-related functions of entorhinal and perifornical stimulation, respectively. These results were further supported by protein changes associated with neurotransmission and neuroplasticity markers measured by western-blotting, mass-spectrometry, and FACS-based methods. Our present study identified a broad range of molecular pathways involved in the entorhinal and perifornical stimulation-induced memory enhancement, which could potentially be a promising therapeutic strategy for dementia.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://brainstimjrnl.com-
dc.relation.ispartofBrain Stimulation-
dc.relation.ispartof3rd International Brain Stimulation Conference, 2019-
dc.subjectElectrical Stimulation-
dc.subjectEntorhinal-
dc.subjectPerifornical-
dc.subjectAgeing-
dc.subjectDementia-
dc.titlePacemaker in the aged brain: From molecular profiling to memory enhancement-
dc.typeConference_Paper-
dc.identifier.emailKoh, J: kohjh@hku.hk-
dc.identifier.emailLim, WL: weilingl@HKUCC-COM.hku.hk-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityLim, LW=rp02088-
dc.identifier.authorityWu, EX=rp00193-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.brs.2018.12.412-
dc.identifier.hkuros303555-
dc.identifier.volume12-
dc.identifier.issue2-
dc.identifier.spage435, abstract no. 476-
dc.identifier.epage435, abstract no. 476-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats