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Article: The relationship between pancreas steatosis and the risk of metabolic syndrome and insulin resistance in Chinese adolescents with concurrent obesity and non‐alcoholic fatty liver disease

TitleThe relationship between pancreas steatosis and the risk of metabolic syndrome and insulin resistance in Chinese adolescents with concurrent obesity and non‐alcoholic fatty liver disease
Authors
Keywordsfatty liver
insulin resistance
magnetic resonance imaging
metabolic syndrome
pancreas
Issue Date2020
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)2047-6310
Citation
Pediatric Obesity, 2020, Epub 2020-04-29 How to Cite?
AbstractBackground: The incidence of childhood obesity and associated comorbidities are on an increasing trend worldwide. More than 340 million children and adolescents aged between 5 and 19 years old were overweight or had obesity in 2016, from which over 124 million children and adolescents (6% of girls and 8% of boys) had obesity. Objective: To describe the relationship between pancreas steatosis, body fat and the risk of metabolic syndrome, insulin resistance in Hong Kong Chinese adolescents with both obesity and non‐alcoholic fatty liver disease (NAFLD). Methods: Fifty two adolescents with obesity and NAFLD were analysed (14‐18 years), stratified into fatty and non‐fatty pancreas groups using chemical shift encoded MRI‐pancreas proton density fat fraction ≥5%. Pancreatic, abdominal subcutaneous adipose tissue (SAT)/visceral adipose tissue (VAT) volumes, biochemical and anthropometric parameters were measured. Mann‐Whitney U test, multiple linear/binary logistic regression analyses and odds ratios were used. Results: Fifty percent had fatty pancreas, 38% had metabolic syndrome and 81% had insulin resistance. Liver proton density fat fraction (PDFF) and VAT were independent predictors of insulin resistance (P = .006, .016). Pancreas and liver PDFF were both independent predictors of beta cells dysfunction (P = .015, .050) and metabolic syndrome (P = .021, .041). Presence of fatty pancreas in obesity was associated with insulin resistance (OR = 1.58, 95% CI = 0.39‐6.4) and metabolic syndrome (OR = 1.70, 95% CI = 0.53‐5.5). Conclusion: A significant causal relationship exists between fatty pancreas, fatty liver, body fat and the risk of developing metabolic syndrome and insulin resistance.
Persistent Identifierhttp://hdl.handle.net/10722/282532
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChiyanika, C-
dc.contributor.authorChan, DFY-
dc.contributor.authorHui, SCN-
dc.contributor.authorSo, H-K-
dc.contributor.authorDeng, M-
dc.contributor.authorYeung, DKW-
dc.contributor.authorNelson, TEAS-
dc.contributor.authorChu, WCW-
dc.date.accessioned2020-05-15T05:29:20Z-
dc.date.available2020-05-15T05:29:20Z-
dc.date.issued2020-
dc.identifier.citationPediatric Obesity, 2020, Epub 2020-04-29-
dc.identifier.issn2047-6302-
dc.identifier.urihttp://hdl.handle.net/10722/282532-
dc.description.abstractBackground: The incidence of childhood obesity and associated comorbidities are on an increasing trend worldwide. More than 340 million children and adolescents aged between 5 and 19 years old were overweight or had obesity in 2016, from which over 124 million children and adolescents (6% of girls and 8% of boys) had obesity. Objective: To describe the relationship between pancreas steatosis, body fat and the risk of metabolic syndrome, insulin resistance in Hong Kong Chinese adolescents with both obesity and non‐alcoholic fatty liver disease (NAFLD). Methods: Fifty two adolescents with obesity and NAFLD were analysed (14‐18 years), stratified into fatty and non‐fatty pancreas groups using chemical shift encoded MRI‐pancreas proton density fat fraction ≥5%. Pancreatic, abdominal subcutaneous adipose tissue (SAT)/visceral adipose tissue (VAT) volumes, biochemical and anthropometric parameters were measured. Mann‐Whitney U test, multiple linear/binary logistic regression analyses and odds ratios were used. Results: Fifty percent had fatty pancreas, 38% had metabolic syndrome and 81% had insulin resistance. Liver proton density fat fraction (PDFF) and VAT were independent predictors of insulin resistance (P = .006, .016). Pancreas and liver PDFF were both independent predictors of beta cells dysfunction (P = .015, .050) and metabolic syndrome (P = .021, .041). Presence of fatty pancreas in obesity was associated with insulin resistance (OR = 1.58, 95% CI = 0.39‐6.4) and metabolic syndrome (OR = 1.70, 95% CI = 0.53‐5.5). Conclusion: A significant causal relationship exists between fatty pancreas, fatty liver, body fat and the risk of developing metabolic syndrome and insulin resistance.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)2047-6310-
dc.relation.ispartofPediatric Obesity-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectfatty liver-
dc.subjectinsulin resistance-
dc.subjectmagnetic resonance imaging-
dc.subjectmetabolic syndrome-
dc.subjectpancreas-
dc.titleThe relationship between pancreas steatosis and the risk of metabolic syndrome and insulin resistance in Chinese adolescents with concurrent obesity and non‐alcoholic fatty liver disease-
dc.typeArticle-
dc.identifier.emailSo, H-K: hkso@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/ijpo.12653-
dc.identifier.scopuseid_2-s2.0-85083966268-
dc.identifier.hkuros309895-
dc.identifier.volumeEpub 2020-04-29-
dc.publisher.placeUnited Kingdom-

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