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- Publisher Website: 10.1073/pnas.91.18.8646
- Scopus: eid_2-s2.0-0027990222
- PMID: 8078938
- WOS: WOS:A1994PE38800069
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Article: Autoantigenic proteins that bind recombinogenic sequences in Epstein-Barr virus and cellular DNA
Title | Autoantigenic proteins that bind recombinogenic sequences in Epstein-Barr virus and cellular DNA |
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Authors | |
Issue Date | 1994 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 1994, v. 91, n. 18, p. 8646-8650 How to Cite? |
Abstract | We have identified conserved autoantigenic cellular proteins that bind to G-rich sequence motifs in recombinogenic regions of Epstein-Barr virus (EBV) DNA. This binding activity, called TRBP, recognizes the EBV terminal repeats, a locus responsible for interconversion of linear and circular EBV DNA. We found that TRBP also binds to EBV DNA sequences involved in deletion of EBNA2, a gene product required for immortalization. We show that TRBP binds sequences present in repetitive cellular DNA, such as variable-number tandem repeats (VNTR) and immunoglobulin heavy-chain class switch regions. We propose that EBV utilizes cellular DNA recombination systems to mediate several types of viral genome alterations. These findings may lead to an understanding of the mechanism of rearrangements of EBV DNA that are a central feature of the biology of the virus. |
Persistent Identifier | http://hdl.handle.net/10722/285549 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sun, Ren | - |
dc.contributor.author | Spain, Tammy A. | - |
dc.contributor.author | Lin, Su Fang | - |
dc.contributor.author | Miller, George | - |
dc.date.accessioned | 2020-08-18T04:56:02Z | - |
dc.date.available | 2020-08-18T04:56:02Z | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 1994, v. 91, n. 18, p. 8646-8650 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/285549 | - |
dc.description.abstract | We have identified conserved autoantigenic cellular proteins that bind to G-rich sequence motifs in recombinogenic regions of Epstein-Barr virus (EBV) DNA. This binding activity, called TRBP, recognizes the EBV terminal repeats, a locus responsible for interconversion of linear and circular EBV DNA. We found that TRBP also binds to EBV DNA sequences involved in deletion of EBNA2, a gene product required for immortalization. We show that TRBP binds sequences present in repetitive cellular DNA, such as variable-number tandem repeats (VNTR) and immunoglobulin heavy-chain class switch regions. We propose that EBV utilizes cellular DNA recombination systems to mediate several types of viral genome alterations. These findings may lead to an understanding of the mechanism of rearrangements of EBV DNA that are a central feature of the biology of the virus. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.title | Autoantigenic proteins that bind recombinogenic sequences in Epstein-Barr virus and cellular DNA | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1073/pnas.91.18.8646 | - |
dc.identifier.pmid | 8078938 | - |
dc.identifier.pmcid | PMC44663 | - |
dc.identifier.scopus | eid_2-s2.0-0027990222 | - |
dc.identifier.volume | 91 | - |
dc.identifier.issue | 18 | - |
dc.identifier.spage | 8646 | - |
dc.identifier.epage | 8650 | - |
dc.identifier.isi | WOS:A1994PE38800069 | - |
dc.identifier.issnl | 0027-8424 | - |