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- Publisher Website: 10.1128/JVI.78.17.9215-9223.2004
- Scopus: eid_2-s2.0-4143088169
- PMID: 15308716
- WOS: WOS:000223386600025
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Article: Generation of a latency-deficient gammaherpesvirus that is protective against secondary infection
Title | Generation of a latency-deficient gammaherpesvirus that is protective against secondary infection |
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Authors | |
Issue Date | 2004 |
Citation | Journal of Virology, 2004, v. 78, n. 17, p. 9215-9223 How to Cite? |
Abstract | Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus-68 (MHV-68) establish latent infections and are associated with various types of malignancies. They are members of the gamma-2 herpes-virus subfamily and encode a replication and transcriptional activator, RTA, which is necessary and sufficient to disrupt latency and initiate the viral lytic cycle in vitro. We have constructed a recombinant MHV-68 virus that overexpresses RTA. This virus has faster replication kinetics in vitro and in vivo, is deficient in establishing latency, exhibits a reduction in the development of a mononucleosis-like disease in mice, and can protect mice against challenge by wild-type MHV-68. The present study, by using MHV-68 as an in vivo model system, demonstrated that RTA plays a critical role in the control of viral latency and suggests that latency is a determinant of viral pathogenesis in vivo. |
Persistent Identifier | http://hdl.handle.net/10722/285618 |
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.378 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rickabaugh, Tammy M. | - |
dc.contributor.author | Brown, Helen J. | - |
dc.contributor.author | Martinez-Guzman, Dee Ann | - |
dc.contributor.author | Wu, Ting Ting | - |
dc.contributor.author | Tong, Leming | - |
dc.contributor.author | Yu, Fuqu | - |
dc.contributor.author | Cole, Steven | - |
dc.contributor.author | Sun, Ren | - |
dc.date.accessioned | 2020-08-18T04:56:13Z | - |
dc.date.available | 2020-08-18T04:56:13Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Journal of Virology, 2004, v. 78, n. 17, p. 9215-9223 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10722/285618 | - |
dc.description.abstract | Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus-68 (MHV-68) establish latent infections and are associated with various types of malignancies. They are members of the gamma-2 herpes-virus subfamily and encode a replication and transcriptional activator, RTA, which is necessary and sufficient to disrupt latency and initiate the viral lytic cycle in vitro. We have constructed a recombinant MHV-68 virus that overexpresses RTA. This virus has faster replication kinetics in vitro and in vivo, is deficient in establishing latency, exhibits a reduction in the development of a mononucleosis-like disease in mice, and can protect mice against challenge by wild-type MHV-68. The present study, by using MHV-68 as an in vivo model system, demonstrated that RTA plays a critical role in the control of viral latency and suggests that latency is a determinant of viral pathogenesis in vivo. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Virology | - |
dc.title | Generation of a latency-deficient gammaherpesvirus that is protective against secondary infection | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1128/JVI.78.17.9215-9223.2004 | - |
dc.identifier.pmid | 15308716 | - |
dc.identifier.pmcid | PMC506911 | - |
dc.identifier.scopus | eid_2-s2.0-4143088169 | - |
dc.identifier.volume | 78 | - |
dc.identifier.issue | 17 | - |
dc.identifier.spage | 9215 | - |
dc.identifier.epage | 9223 | - |
dc.identifier.isi | WOS:000223386600025 | - |
dc.identifier.issnl | 0022-538X | - |