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- Publisher Website: 10.1038/embor.2010.132
- Scopus: eid_2-s2.0-77957223964
- PMID: 20847741
- WOS: WOS:000282210500017
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Article: MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle
Title | MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle |
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Authors | |
Keywords | miRNA RISC viral life cycle KSHV |
Issue Date | 2010 |
Citation | EMBO Reports, 2010, v. 11, n. 10, p. 784-790 How to Cite? |
Abstract | Kaposi's sarcoma-associated herpesvirus (KSHV) is linked with Kaposi's sarcoma and lymphomas. The pathogenesis of KSHV depends on the balance between two phases of the viral cycle: latency and lytic replication. In this study, we report that KSHV-encoded microRNAs (miRNAs) function as regulators by maintaining viral latency and inhibiting viral lytic replication. MiRNAs are short, noncoding, small RNAs that post-transcriptionally regulate the expression of messenger RNAs. Of the 12 viral miRNAs expressed in latent KSHV-infected cells, we observed that expression of miR-K3 can suppress both viral lytic replication and gene expression. Further experiments indicate that miR-K3 can regulate viral latency by targeting nuclear factor I/B. Nuclear factor I/B can activate the promoter of the viral immediate-early transactivator replication and transcription activator (RTA), and depletion of nuclear factor I/B by short hairpin RNAs had similar effects on the viral life cycle to those of miR-K3. Our results suggest a role for KSHV miRNAs in regulating the viral life cycle. © 2010 European Molecular Biology Organization. |
Persistent Identifier | http://hdl.handle.net/10722/285672 |
ISSN | 2023 Impact Factor: 6.5 2023 SCImago Journal Rankings: 3.193 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lu, Chih Chung | - |
dc.contributor.author | Li, Zhonghan | - |
dc.contributor.author | Chu, Chia Ying | - |
dc.contributor.author | Feng, Jiaying | - |
dc.contributor.author | Feng, Jun | - |
dc.contributor.author | Sun, Ren | - |
dc.contributor.author | Rana, Tariq M. | - |
dc.date.accessioned | 2020-08-18T04:56:21Z | - |
dc.date.available | 2020-08-18T04:56:21Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | EMBO Reports, 2010, v. 11, n. 10, p. 784-790 | - |
dc.identifier.issn | 1469-221X | - |
dc.identifier.uri | http://hdl.handle.net/10722/285672 | - |
dc.description.abstract | Kaposi's sarcoma-associated herpesvirus (KSHV) is linked with Kaposi's sarcoma and lymphomas. The pathogenesis of KSHV depends on the balance between two phases of the viral cycle: latency and lytic replication. In this study, we report that KSHV-encoded microRNAs (miRNAs) function as regulators by maintaining viral latency and inhibiting viral lytic replication. MiRNAs are short, noncoding, small RNAs that post-transcriptionally regulate the expression of messenger RNAs. Of the 12 viral miRNAs expressed in latent KSHV-infected cells, we observed that expression of miR-K3 can suppress both viral lytic replication and gene expression. Further experiments indicate that miR-K3 can regulate viral latency by targeting nuclear factor I/B. Nuclear factor I/B can activate the promoter of the viral immediate-early transactivator replication and transcription activator (RTA), and depletion of nuclear factor I/B by short hairpin RNAs had similar effects on the viral life cycle to those of miR-K3. Our results suggest a role for KSHV miRNAs in regulating the viral life cycle. © 2010 European Molecular Biology Organization. | - |
dc.language | eng | - |
dc.relation.ispartof | EMBO Reports | - |
dc.subject | miRNA | - |
dc.subject | RISC | - |
dc.subject | viral life cycle | - |
dc.subject | KSHV | - |
dc.title | MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1038/embor.2010.132 | - |
dc.identifier.pmid | 20847741 | - |
dc.identifier.pmcid | PMC2948186 | - |
dc.identifier.scopus | eid_2-s2.0-77957223964 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 784 | - |
dc.identifier.epage | 790 | - |
dc.identifier.eissn | 1469-3178 | - |
dc.identifier.isi | WOS:000282210500017 | - |
dc.identifier.issnl | 1469-221X | - |