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- Publisher Website: 10.1016/j.virol.2011.11.012
- Scopus: eid_2-s2.0-84855341495
- PMID: 22169075
- WOS: WOS:000299756100004
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Article: Persistent infection of a gammaherpesvirus in the central nervous system
Title | Persistent infection of a gammaherpesvirus in the central nervous system |
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Authors | |
Keywords | Central nervous system Gammaherpesvirus Persistent infection Bioluminescence imaging |
Issue Date | 2012 |
Citation | Virology, 2012, v. 423, n. 1, p. 23-29 How to Cite? |
Abstract | Human gammaherpesvirus infections of the central nervous system (CNS) have been linked to various neurological diseases. Murine gammaherpesvirus 68 (MHV-68), genetically related and biologically similar to human gammaherpesviruses, infects the CNS in laboratory mice. However, viral persistency of MHV-68 has not been studied following CNS infection. In this study, we undertook the noninvasive bioluminescence imaging of a recombinant MHV-68 expressing the firefly luciferase (M3FL) to monitor virus progression after CNS infection. The M3FL virus inoculated in the brain systemically spread to the abdominal area in bioluminescence imaging, which was further confirmed by detection of viral genome and transcripts. The disseminated wild-type virus established latency in the spleen. Moreover, the treatment of the infected mice with CsA induced reactivation of latent MHV-68 from the brain and the spleen. Our results suggest that MHV-68 may persist both inside and outside the CNS once it gains access to the CNS. © 2011 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/285689 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.838 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kang, Hye Ri | - |
dc.contributor.author | Cho, Hye Jeong | - |
dc.contributor.author | Kim, Sungbum | - |
dc.contributor.author | Song, In Ho | - |
dc.contributor.author | Lee, Tae Sup | - |
dc.contributor.author | Hwang, Seungmin | - |
dc.contributor.author | Sun, Ren | - |
dc.contributor.author | Song, Moon Jung | - |
dc.date.accessioned | 2020-08-18T04:56:23Z | - |
dc.date.available | 2020-08-18T04:56:23Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Virology, 2012, v. 423, n. 1, p. 23-29 | - |
dc.identifier.issn | 0042-6822 | - |
dc.identifier.uri | http://hdl.handle.net/10722/285689 | - |
dc.description.abstract | Human gammaherpesvirus infections of the central nervous system (CNS) have been linked to various neurological diseases. Murine gammaherpesvirus 68 (MHV-68), genetically related and biologically similar to human gammaherpesviruses, infects the CNS in laboratory mice. However, viral persistency of MHV-68 has not been studied following CNS infection. In this study, we undertook the noninvasive bioluminescence imaging of a recombinant MHV-68 expressing the firefly luciferase (M3FL) to monitor virus progression after CNS infection. The M3FL virus inoculated in the brain systemically spread to the abdominal area in bioluminescence imaging, which was further confirmed by detection of viral genome and transcripts. The disseminated wild-type virus established latency in the spleen. Moreover, the treatment of the infected mice with CsA induced reactivation of latent MHV-68 from the brain and the spleen. Our results suggest that MHV-68 may persist both inside and outside the CNS once it gains access to the CNS. © 2011 Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Virology | - |
dc.subject | Central nervous system | - |
dc.subject | Gammaherpesvirus | - |
dc.subject | Persistent infection | - |
dc.subject | Bioluminescence imaging | - |
dc.title | Persistent infection of a gammaherpesvirus in the central nervous system | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.virol.2011.11.012 | - |
dc.identifier.pmid | 22169075 | - |
dc.identifier.scopus | eid_2-s2.0-84855341495 | - |
dc.identifier.volume | 423 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 23 | - |
dc.identifier.epage | 29 | - |
dc.identifier.eissn | 1096-0341 | - |
dc.identifier.isi | WOS:000299756100004 | - |
dc.identifier.issnl | 0042-6822 | - |