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- Publisher Website: 10.1126/science.abb7271
- Scopus: eid_2-s2.0-85085636280
- PMID: 32467391
- WOS: WOS:000538332600047
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Article: Total synthesis of bryostatin 3
Title | Total synthesis of bryostatin 3 |
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Authors | |
Keywords | amino acid sequence atom catalysis geometry oxidative coupling |
Issue Date | 2020 |
Publisher | American Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org |
Citation | Science, 2020, v. 368 n. 6494, p. 1007-1011 How to Cite? |
Abstract | Bryostatins are a family of 21 complex marine natural products with a wide range of potent biological activities. Among all the 21 bryostatins, bryostatin 3 is structurally the most complex. Whereas nine total syntheses of bryostatins have been achieved to date, bryostatin 3 has only been targeted once and required the highest number of steps to synthesize (43 steps in the longest linear sequence and 88 total steps). Here, we report a concise total synthesis of bryostatin 3 using 22 steps in the longest linear sequence and 31 total steps through a highly convergent synthetic plan by the use of highly atom-economical and chemoselective transformations in which alkynes played a major role in reducing step count. |
Persistent Identifier | http://hdl.handle.net/10722/286168 |
ISSN | 2023 Impact Factor: 44.7 2023 SCImago Journal Rankings: 11.902 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Trost, BM | - |
dc.contributor.author | Wang, Y | - |
dc.contributor.author | Buckl, AK | - |
dc.contributor.author | Huang, Z | - |
dc.contributor.author | Nguyen, MH | - |
dc.contributor.author | Kuzmina, O | - |
dc.date.accessioned | 2020-08-31T07:00:06Z | - |
dc.date.available | 2020-08-31T07:00:06Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Science, 2020, v. 368 n. 6494, p. 1007-1011 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10722/286168 | - |
dc.description.abstract | Bryostatins are a family of 21 complex marine natural products with a wide range of potent biological activities. Among all the 21 bryostatins, bryostatin 3 is structurally the most complex. Whereas nine total syntheses of bryostatins have been achieved to date, bryostatin 3 has only been targeted once and required the highest number of steps to synthesize (43 steps in the longest linear sequence and 88 total steps). Here, we report a concise total synthesis of bryostatin 3 using 22 steps in the longest linear sequence and 31 total steps through a highly convergent synthetic plan by the use of highly atom-economical and chemoselective transformations in which alkynes played a major role in reducing step count. | - |
dc.language | eng | - |
dc.publisher | American Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org | - |
dc.relation.ispartof | Science | - |
dc.rights | Science. Copyright © American Association for the Advancement of Science. | - |
dc.rights | This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in [Science Journal Title] on [Volume number and date], DOI: [insert DOI number]. | - |
dc.subject | amino acid sequence | - |
dc.subject | atom | - |
dc.subject | catalysis | - |
dc.subject | geometry | - |
dc.subject | oxidative coupling | - |
dc.title | Total synthesis of bryostatin 3 | - |
dc.type | Article | - |
dc.identifier.email | Huang, Z: huangzx@hku.hk | - |
dc.identifier.authority | Huang, Z=rp02585 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1126/science.abb7271 | - |
dc.identifier.pmid | 32467391 | - |
dc.identifier.scopus | eid_2-s2.0-85085636280 | - |
dc.identifier.hkuros | 313703 | - |
dc.identifier.volume | 368 | - |
dc.identifier.issue | 6494 | - |
dc.identifier.spage | 1007 | - |
dc.identifier.epage | 1011 | - |
dc.identifier.isi | WOS:000538332600047 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0036-8075 | - |