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Article: The acute effects of cigarette smoke exposure on muscle fiber type dynamics in rats

TitleThe acute effects of cigarette smoke exposure on muscle fiber type dynamics in rats
Authors
Issue Date2020
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2020, v. 15 n. 5, article no. e0233523 How to Cite?
AbstractReduced exercise capacity is common in people with chronic obstructive pulmonary diseases (COPD) and chronic smokers and is suggested to be related to skeletal muscle dysfunction. Previous studies using human muscle biopsies have shown fiber-type shifting in chronic smokers particularly those with COPD. These results, however, are confounded with aging effects because people with COPD tend to be older. In the present study, we implemented an acute 7-day cigarette smoke-exposed model using Sprague-Dawley rats to evaluate early effects of cigarette smoking on soleus muscles. Rats (n = 5 per group) were randomly assigned to either a sham air (SA) or cigarette smoking (CS) groups of three different concentrations of total particulate matters (TPM) (CSTPM2.5, CSTPM5, CSTPM10). Significantly lower percentages of type I and higher type IIa fiber were detected in the soleus muscle in CS groups when compared with SA group. Of these, only CSTMP10 group exhibited significantly lower citrate synthase activity and higher muscle tumor necrosis factor-α level than that of SA group. Tumor necrosis factor-α level was correlated with the percentage of type I and IIa fibers. However, no significant between-group differences were found in fiber cross-sectional area, physical activities, or lung function assessments. In conclusion, acute smoking may directly trigger the onset of glycolytic fiber type shift in skeletal muscle independent of aging.
Persistent Identifierhttp://hdl.handle.net/10722/286240
ISSN
2019 Impact Factor: 2.74
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, K-
dc.contributor.authorFung, TK-
dc.contributor.authorMak, JCW-
dc.contributor.authorCheung, S-
dc.contributor.authorHe, W-
dc.contributor.authorLeung, JW-
dc.contributor.authorLau, BWM-
dc.contributor.authorNgai, SPC-
dc.date.accessioned2020-08-31T07:01:08Z-
dc.date.available2020-08-31T07:01:08Z-
dc.date.issued2020-
dc.identifier.citationPLoS One, 2020, v. 15 n. 5, article no. e0233523-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/286240-
dc.description.abstractReduced exercise capacity is common in people with chronic obstructive pulmonary diseases (COPD) and chronic smokers and is suggested to be related to skeletal muscle dysfunction. Previous studies using human muscle biopsies have shown fiber-type shifting in chronic smokers particularly those with COPD. These results, however, are confounded with aging effects because people with COPD tend to be older. In the present study, we implemented an acute 7-day cigarette smoke-exposed model using Sprague-Dawley rats to evaluate early effects of cigarette smoking on soleus muscles. Rats (n = 5 per group) were randomly assigned to either a sham air (SA) or cigarette smoking (CS) groups of three different concentrations of total particulate matters (TPM) (CSTPM2.5, CSTPM5, CSTPM10). Significantly lower percentages of type I and higher type IIa fiber were detected in the soleus muscle in CS groups when compared with SA group. Of these, only CSTMP10 group exhibited significantly lower citrate synthase activity and higher muscle tumor necrosis factor-α level than that of SA group. Tumor necrosis factor-α level was correlated with the percentage of type I and IIa fibers. However, no significant between-group differences were found in fiber cross-sectional area, physical activities, or lung function assessments. In conclusion, acute smoking may directly trigger the onset of glycolytic fiber type shift in skeletal muscle independent of aging.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS ONE-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleThe acute effects of cigarette smoke exposure on muscle fiber type dynamics in rats-
dc.typeArticle-
dc.identifier.emailMak, JCW: judithmak@hku.hk-
dc.identifier.authorityMak, JCW=rp00352-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0233523-
dc.identifier.pmid32433675-
dc.identifier.pmcidPMC7239437-
dc.identifier.scopuseid_2-s2.0-85085156897-
dc.identifier.hkuros313204-
dc.identifier.volume15-
dc.identifier.issue5-
dc.identifier.spagearticle no. e0233523-
dc.identifier.epagearticle no. e0233523-
dc.identifier.isiWOS:000537510100060-
dc.publisher.placeUnited States-

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