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Article: The Roles of Immune Cells in the Pathogenesis of Fibrosis

TitleThe Roles of Immune Cells in the Pathogenesis of Fibrosis
Authors
KeywordsFibrosis
Innate immune cells
Adaptive immune cells
Myofibroblast
Molecular mechanism
Issue Date2020
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2020, v. 21 n. 15, article no. 5203 How to Cite?
AbstractTissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.
Persistent Identifierhttp://hdl.handle.net/10722/286395
ISSN
2011 Impact Factor: 2.598
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorHuang, E-
dc.contributor.authorPeng, N-
dc.contributor.authorXiao, F-
dc.contributor.authorHu, D-
dc.contributor.authorWang, X-
dc.contributor.authorLu, L-
dc.date.accessioned2020-08-31T07:03:17Z-
dc.date.available2020-08-31T07:03:17Z-
dc.date.issued2020-
dc.identifier.citationInternational Journal of Molecular Sciences, 2020, v. 21 n. 15, article no. 5203-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/286395-
dc.description.abstractTissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectFibrosis-
dc.subjectInnate immune cells-
dc.subjectAdaptive immune cells-
dc.subjectMyofibroblast-
dc.subjectMolecular mechanism-
dc.titleThe Roles of Immune Cells in the Pathogenesis of Fibrosis-
dc.typeArticle-
dc.identifier.emailXiao, F: xiaof@hku.hk-
dc.identifier.emailWang, X: xiaohuiwang@hku.hk-
dc.identifier.emailLu, L: liweilu@hku.hk-
dc.identifier.authorityWang, X=rp02664-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms21155203-
dc.identifier.pmid32708044-
dc.identifier.pmcidPMC7432671-
dc.identifier.scopuseid_2-s2.0-85088304822-
dc.identifier.hkuros313422-
dc.identifier.volume21-
dc.identifier.issue15-
dc.identifier.spagearticle no. 5203-
dc.identifier.epagearticle no. 5203-
dc.publisher.placeSwitzerland-

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