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- Publisher Website: 10.1038/s41416-020-0823-9
- Scopus: eid_2-s2.0-85082927906
- PMID: 32231294
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Article: Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential
Title | Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential |
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Authors | |
Keywords | cancer genetics cancer stem cell carcinogenesis cell component cell differentiation |
Issue Date | 2020 |
Publisher | Springer Nature, published in association with Cancer Research UK. The Journal's web site is located at http://www.nature.com/bjc |
Citation | British Journal of Cancer, 2020, v. 122 n. 10, p. 1428-1440 How to Cite? |
Abstract | Cancer stemness, referring to the stem-cell-like phenotype of cancer cells, has been recognised to play important roles in different aspects of hepatocarcinogenesis. A number of well-established cell-surface markers already exist for liver cancer stem cells, with potential new markers of liver cancer stem cells being identified. Both genetic and epigenetic factors that affect various signalling pathways are known to contribute to cancer stemness. In addition, the tumour microenvironment—both physical and cellular—is known to play an important role in regulating cancer stemness, and the potential interaction between cancer stem cells and their microenvironment has provided insight into the regulation of the tumour-initiating ability as well as the cellular plasticity of liver CSCs. Potential specific therapeutic targeting of liver cancer stemness is also discussed. With increased knowledge, effective druggable targets might be identified, with the aim of improving treatment outcome by reducing chemoresistance. |
Persistent Identifier | http://hdl.handle.net/10722/286400 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 3.000 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tsui, YM | - |
dc.contributor.author | Chan, LK | - |
dc.contributor.author | Ng, IOL | - |
dc.date.accessioned | 2020-08-31T07:03:21Z | - |
dc.date.available | 2020-08-31T07:03:21Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | British Journal of Cancer, 2020, v. 122 n. 10, p. 1428-1440 | - |
dc.identifier.issn | 0007-0920 | - |
dc.identifier.uri | http://hdl.handle.net/10722/286400 | - |
dc.description.abstract | Cancer stemness, referring to the stem-cell-like phenotype of cancer cells, has been recognised to play important roles in different aspects of hepatocarcinogenesis. A number of well-established cell-surface markers already exist for liver cancer stem cells, with potential new markers of liver cancer stem cells being identified. Both genetic and epigenetic factors that affect various signalling pathways are known to contribute to cancer stemness. In addition, the tumour microenvironment—both physical and cellular—is known to play an important role in regulating cancer stemness, and the potential interaction between cancer stem cells and their microenvironment has provided insight into the regulation of the tumour-initiating ability as well as the cellular plasticity of liver CSCs. Potential specific therapeutic targeting of liver cancer stemness is also discussed. With increased knowledge, effective druggable targets might be identified, with the aim of improving treatment outcome by reducing chemoresistance. | - |
dc.language | eng | - |
dc.publisher | Springer Nature, published in association with Cancer Research UK. The Journal's web site is located at http://www.nature.com/bjc | - |
dc.relation.ispartof | British Journal of Cancer | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | cancer genetics | - |
dc.subject | cancer stem cell | - |
dc.subject | carcinogenesis | - |
dc.subject | cell component | - |
dc.subject | cell differentiation | - |
dc.title | Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential | - |
dc.type | Article | - |
dc.identifier.email | Tsui, YM: ymtsui@hku.hk | - |
dc.identifier.email | Chan, LK: lkchan1@hku.hk | - |
dc.identifier.email | Ng, IOL: iolng@hku.hk | - |
dc.identifier.authority | Chan, LK=rp02289 | - |
dc.identifier.authority | Ng, IOL=rp00335 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41416-020-0823-9 | - |
dc.identifier.pmid | 32231294 | - |
dc.identifier.pmcid | PMC7217836 | - |
dc.identifier.scopus | eid_2-s2.0-85082927906 | - |
dc.identifier.hkuros | 313907 | - |
dc.identifier.volume | 122 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 1428 | - |
dc.identifier.epage | 1440 | - |
dc.identifier.isi | WOS:000522379800004 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0007-0920 | - |