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Article: Using Sox2 to alleviate the hallmarks of age-related hearing loss

TitleUsing Sox2 to alleviate the hallmarks of age-related hearing loss
Authors
KeywordsAge-related hearing loss
Cochlea
The organ of Corti
Hair cell restoration
Hair cell development
Issue Date2020
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/arr
Citation
Ageing Research Reviews, 2020, v. 59, p. article no. 101042 How to Cite?
AbstractAge-related hearing loss (ARHL) is the most prevalent sensory deficit. ARHL reduces the quality of life of the growing population, setting seniors up for the enhanced mental decline. The size of the needy population, the structural deficit, and a likely research strategy for effective treatment of chronic neurosensory hearing in the elderly are needed. Although there has been profound advancement in auditory regenerative research, there remain multiple challenges to restore hearing loss. Thus, additional investigations are required, using novel tools. We propose how the (1) flat epithelium, remaining after the organ of Corti has deteriorated, can be converted to the repaired-sensory epithelium, using Sox2. This will include (2) developing an artificial gene regulatory network transmitted by (3) large viral vectors to the flat epithelium to stimulate remnants of the organ of Corti to restore hair cells. We hope to unite with our proposal toward the common goal, eventually restoring a functional human hearing organ by transforming the flat epithelial cells left after the organ of Corti loss.
Persistent Identifierhttp://hdl.handle.net/10722/287130
ISSN
2019 Impact Factor: 10.616
2015 SCImago Journal Rankings: 3.289
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorYamoah, EN-
dc.contributor.authorLi, M-
dc.contributor.authorShah, A-
dc.contributor.authorElliott, KL-
dc.contributor.authorCheah, K-
dc.contributor.authorXu, PX-
dc.contributor.authorPhillips, S-
dc.contributor.authorYoung, SM-
dc.contributor.authorEberl, DF-
dc.contributor.authorFritzsch, B-
dc.date.accessioned2020-09-22T02:56:13Z-
dc.date.available2020-09-22T02:56:13Z-
dc.date.issued2020-
dc.identifier.citationAgeing Research Reviews, 2020, v. 59, p. article no. 101042-
dc.identifier.issn1568-1637-
dc.identifier.urihttp://hdl.handle.net/10722/287130-
dc.description.abstractAge-related hearing loss (ARHL) is the most prevalent sensory deficit. ARHL reduces the quality of life of the growing population, setting seniors up for the enhanced mental decline. The size of the needy population, the structural deficit, and a likely research strategy for effective treatment of chronic neurosensory hearing in the elderly are needed. Although there has been profound advancement in auditory regenerative research, there remain multiple challenges to restore hearing loss. Thus, additional investigations are required, using novel tools. We propose how the (1) flat epithelium, remaining after the organ of Corti has deteriorated, can be converted to the repaired-sensory epithelium, using Sox2. This will include (2) developing an artificial gene regulatory network transmitted by (3) large viral vectors to the flat epithelium to stimulate remnants of the organ of Corti to restore hair cells. We hope to unite with our proposal toward the common goal, eventually restoring a functional human hearing organ by transforming the flat epithelial cells left after the organ of Corti loss.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/arr-
dc.relation.ispartofAgeing Research Reviews-
dc.subjectAge-related hearing loss-
dc.subjectCochlea-
dc.subjectThe organ of Corti-
dc.subjectHair cell restoration-
dc.subjectHair cell development-
dc.titleUsing Sox2 to alleviate the hallmarks of age-related hearing loss-
dc.typeArticle-
dc.identifier.emailCheah, K: hrmbdkc@hku.hk-
dc.identifier.authorityCheah, K=rp00342-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.arr.2020.101042-
dc.identifier.pmid32173536-
dc.identifier.pmcidPMC7261488-
dc.identifier.scopuseid_2-s2.0-85081982295-
dc.identifier.hkuros314591-
dc.identifier.volume59-
dc.identifier.spagearticle no. 101042-
dc.identifier.epagearticle no. 101042-
dc.publisher.placeIreland-

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