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Article: Skin prick testing a better predictor than blood testing for the diagnosis of peanut allergy in Chinese children

TitleSkin prick testing a better predictor than blood testing for the diagnosis of peanut allergy in Chinese children
Authors
KeywordsPeanut Allergy
Chinese
Children
Skin Prick Test
Component Resolved Diagnostics
Issue Date2019
PublisherThe Allergy and Immunology Society of Thailand. The Journal's web site is located at http://apjai-journal.org/
Citation
Asian Pacific Journal of Allergy and Immunology, 2019, Epub 2019-07-16 How to Cite?
AbstractBackground: Peanut allergy is common in Chinese children, yet the most predictive diagnostic cut-offs for skin prick test (SPT) and blood testing in this population are unclear. Objectives: We aimed to determine the optimal cut-off values for whole-peanut SPT, specific IgE (sIgE) and component-resolved diagnostics (CRD) for Chinese children based on outcomes of open oral food challenges (OFC) to peanut. Methods: We recruited ethnic-Chinese patients 1-18 years old who were suspected of having peanut allergy based on a history of reactions after exposure or sensitization although peanut naïve. Considering the AUC value of 0.8, 80% power and 5% level of significance with two tails, 26 patients were needed. Sensitivities, specificities, positive and negative predictive values, and receiver operating characteristic curves (ROCs) and their area-under-curves (AUCs) for SPT, peanut sIgE, and CRD were compared. Results: Thirty-one subjects participated. Only SPT reached statistical significance (AUC 0.91, p = 0.0001), but not the other tests. Seven retrospective data were added to optimize the power. SPT remained to be the best predictor, followed by Ara h 2 sIgE (AUC 0.72, p = 0.02). An SPT wheal size of 3 mm and Ara h 2 sIgE of 0.14 kU(A)/L yielded the highest Youden’s index. The specificity of SPT and Ara h 2 sIgE reached 94% at 6 mm and 0.74 kU(A)/L, respectively. Comparisons of ROCs revealed that SPT was significantly better than Ara h 2 sIgE (p = 0.03) and whole-peanut sIgE (AUC 0.61, p = 0.26). Conclusion: In Chinese children, SPT appeared to be the best predictor for peanut allergy, followed by Ara h 2 sIgE.
Persistent Identifierhttp://hdl.handle.net/10722/287622
ISSN
2019 Impact Factor: 1.247
2015 SCImago Journal Rankings: 0.560

 

DC FieldValueLanguage
dc.contributor.authorChua, GT-
dc.contributor.authorChong, PCY-
dc.contributor.authorAu, EYL-
dc.contributor.authorCheong, KN-
dc.contributor.authorWong, WHS-
dc.contributor.authorChan, EYT-
dc.contributor.authorHo, MHK-
dc.contributor.authorLau, YL-
dc.contributor.authorS Da Rosa Duque, J-
dc.date.accessioned2020-10-05T12:00:47Z-
dc.date.available2020-10-05T12:00:47Z-
dc.date.issued2019-
dc.identifier.citationAsian Pacific Journal of Allergy and Immunology, 2019, Epub 2019-07-16-
dc.identifier.issn0125-877X-
dc.identifier.urihttp://hdl.handle.net/10722/287622-
dc.description.abstractBackground: Peanut allergy is common in Chinese children, yet the most predictive diagnostic cut-offs for skin prick test (SPT) and blood testing in this population are unclear. Objectives: We aimed to determine the optimal cut-off values for whole-peanut SPT, specific IgE (sIgE) and component-resolved diagnostics (CRD) for Chinese children based on outcomes of open oral food challenges (OFC) to peanut. Methods: We recruited ethnic-Chinese patients 1-18 years old who were suspected of having peanut allergy based on a history of reactions after exposure or sensitization although peanut naïve. Considering the AUC value of 0.8, 80% power and 5% level of significance with two tails, 26 patients were needed. Sensitivities, specificities, positive and negative predictive values, and receiver operating characteristic curves (ROCs) and their area-under-curves (AUCs) for SPT, peanut sIgE, and CRD were compared. Results: Thirty-one subjects participated. Only SPT reached statistical significance (AUC 0.91, p = 0.0001), but not the other tests. Seven retrospective data were added to optimize the power. SPT remained to be the best predictor, followed by Ara h 2 sIgE (AUC 0.72, p = 0.02). An SPT wheal size of 3 mm and Ara h 2 sIgE of 0.14 kU(A)/L yielded the highest Youden’s index. The specificity of SPT and Ara h 2 sIgE reached 94% at 6 mm and 0.74 kU(A)/L, respectively. Comparisons of ROCs revealed that SPT was significantly better than Ara h 2 sIgE (p = 0.03) and whole-peanut sIgE (AUC 0.61, p = 0.26). Conclusion: In Chinese children, SPT appeared to be the best predictor for peanut allergy, followed by Ara h 2 sIgE.-
dc.languageeng-
dc.publisherThe Allergy and Immunology Society of Thailand. The Journal's web site is located at http://apjai-journal.org/-
dc.relation.ispartofAsian Pacific Journal of Allergy and Immunology-
dc.subjectPeanut Allergy-
dc.subjectChinese-
dc.subjectChildren-
dc.subjectSkin Prick Test-
dc.subjectComponent Resolved Diagnostics-
dc.titleSkin prick testing a better predictor than blood testing for the diagnosis of peanut allergy in Chinese children-
dc.typeArticle-
dc.identifier.emailChua, GT: cgt560@hku.hk-
dc.identifier.emailChong, PCY: chongpcy@hku.hk-
dc.identifier.emailCheong, KN: kncheong@hku.hk-
dc.identifier.emailWong, WHS: whswong@hku.hk-
dc.identifier.emailHo, MHK: marcoho@hku.hk-
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.emailS Da Rosa Duque, J: jsrduque@hku.hk-
dc.identifier.authorityChua, GT=rp02684-
dc.identifier.authorityLau, YL=rp00361-
dc.identifier.authorityS Da Rosa Duque, J=rp02340-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.12932/AP-110319-0519-
dc.identifier.pmid31310149-
dc.identifier.hkuros314790-
dc.identifier.volumeEpub 2019-07-16-
dc.publisher.placeThailand-
dc.identifier.issnl0125-877X-

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