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- Publisher Website: 10.1016/j.tips.2020.08.002
- Scopus: eid_2-s2.0-85090489942
- PMID: 32893004
- WOS: WOS:000572690600007
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Article: Inhaled RNA Therapy: From Promise to Reality
Title | Inhaled RNA Therapy: From Promise to Reality |
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Authors | |
Keywords | aerosol mRNA nonviral vector pulmonary delivery respiratory diseases |
Issue Date | 2020 |
Publisher | Elsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tips |
Citation | Trends in Pharmacological Sciences, 2020, v. 41 n. 10, p. 715-729 How to Cite? |
Abstract | RNA-based medicine is receiving growing attention for its diverse roles and potential therapeutic capacity. The largest obstacle in its clinical translation remains identifying a safe and effective delivery system. Studies investigating RNA therapeutics in pulmonary diseases have rapidly expanded and drug administration by inhalation allows the direct delivery of RNA therapeutics to the target site of action while minimizing systemic exposure. In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors. We also discuss the major knowledge gaps that require thorough investigation and provide insights that will help advance this exciting field towards the bedside. |
Persistent Identifier | http://hdl.handle.net/10722/287700 |
ISSN | 2023 Impact Factor: 13.9 2023 SCImago Journal Rankings: 3.232 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chow, MYT | - |
dc.contributor.author | QIU, Y | - |
dc.contributor.author | Lam, JKW | - |
dc.date.accessioned | 2020-10-05T12:01:58Z | - |
dc.date.available | 2020-10-05T12:01:58Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Trends in Pharmacological Sciences, 2020, v. 41 n. 10, p. 715-729 | - |
dc.identifier.issn | 0165-6147 | - |
dc.identifier.uri | http://hdl.handle.net/10722/287700 | - |
dc.description.abstract | RNA-based medicine is receiving growing attention for its diverse roles and potential therapeutic capacity. The largest obstacle in its clinical translation remains identifying a safe and effective delivery system. Studies investigating RNA therapeutics in pulmonary diseases have rapidly expanded and drug administration by inhalation allows the direct delivery of RNA therapeutics to the target site of action while minimizing systemic exposure. In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors. We also discuss the major knowledge gaps that require thorough investigation and provide insights that will help advance this exciting field towards the bedside. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/tips | - |
dc.relation.ispartof | Trends in Pharmacological Sciences | - |
dc.subject | aerosol | - |
dc.subject | mRNA | - |
dc.subject | nonviral vector | - |
dc.subject | pulmonary delivery | - |
dc.subject | respiratory diseases | - |
dc.title | Inhaled RNA Therapy: From Promise to Reality | - |
dc.type | Article | - |
dc.identifier.email | Chow, MYT: mytchow@hku.hk | - |
dc.identifier.email | Lam, JKW: jkwlam@hku.hk | - |
dc.identifier.authority | Lam, JKW=rp01346 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.tips.2020.08.002 | - |
dc.identifier.pmid | 32893004 | - |
dc.identifier.pmcid | PMC7471058 | - |
dc.identifier.scopus | eid_2-s2.0-85090489942 | - |
dc.identifier.hkuros | 314832 | - |
dc.identifier.volume | 41 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 715 | - |
dc.identifier.epage | 729 | - |
dc.identifier.isi | WOS:000572690600007 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0165-6147 | - |