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Article: The effect of influenza vaccination history on changes in hemagglutination inhibition titers after receipt of the 2015–2016 influenza vaccine in older adults in Hong Kong

TitleThe effect of influenza vaccination history on changes in hemagglutination inhibition titers after receipt of the 2015–2016 influenza vaccine in older adults in Hong Kong
Authors
Keywordsinfluenza vaccine
repeated vaccination
immune response
Issue Date2020
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
The Journal of Infectious Diseases, 2020, v. 221 n. 1, p. 33-41 How to Cite?
AbstractBackground: Immune responses to influenza vaccination can be weaker in older adults than in other age groups. We hypothesized that antibody responses would be particularly weak among repeat vaccinees when the current and prior season vaccine components are the same. Methods: An observational study was conducted among 827 older adults (aged ≥75 years) in Hong Kong. Serum samples were collected immediately before and 1 month after receipt of the 2015–2016 quadrivalent inactivated influenza vaccine. We measured antibody titers with the hemagglutination inhibition assay and compared the mean fold rise from prevaccination to postvaccination titers and the proportions with postvaccination titers ≥40 or ≥160. Results: Participants who reported receipt of vaccination during either of the previous 2 years had a lower mean fold rise against all strains than with those who did not. Mean fold rises for A(H3N2) and B/Yamagata were particularly weak after repeated vaccination with the same vaccine strain, but we did not generally find significant differences in the proportions of participants with postvaccination titers ≥40 and ≥160. Conclusions: Overall, we found that reduced antibody responses in repeat vaccinees were particularly reduced among older adults who had received vaccination against the same strains in preceding years.
Descriptionlink_to_subscribed_fulltext
Persistent Identifierhttp://hdl.handle.net/10722/288381
ISSN
2019 Impact Factor: 5.022
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, TWY-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorFang, VJ-
dc.contributor.authorYau, EM-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorTam, YH-
dc.contributor.authorCowling, BJ-
dc.date.accessioned2020-10-05T12:12:02Z-
dc.date.available2020-10-05T12:12:02Z-
dc.date.issued2020-
dc.identifier.citationThe Journal of Infectious Diseases, 2020, v. 221 n. 1, p. 33-41-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/288381-
dc.descriptionlink_to_subscribed_fulltext-
dc.description.abstractBackground: Immune responses to influenza vaccination can be weaker in older adults than in other age groups. We hypothesized that antibody responses would be particularly weak among repeat vaccinees when the current and prior season vaccine components are the same. Methods: An observational study was conducted among 827 older adults (aged ≥75 years) in Hong Kong. Serum samples were collected immediately before and 1 month after receipt of the 2015–2016 quadrivalent inactivated influenza vaccine. We measured antibody titers with the hemagglutination inhibition assay and compared the mean fold rise from prevaccination to postvaccination titers and the proportions with postvaccination titers ≥40 or ≥160. Results: Participants who reported receipt of vaccination during either of the previous 2 years had a lower mean fold rise against all strains than with those who did not. Mean fold rises for A(H3N2) and B/Yamagata were particularly weak after repeated vaccination with the same vaccine strain, but we did not generally find significant differences in the proportions of participants with postvaccination titers ≥40 and ≥160. Conclusions: Overall, we found that reduced antibody responses in repeat vaccinees were particularly reduced among older adults who had received vaccination against the same strains in preceding years.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org-
dc.relation.ispartofThe Journal of Infectious Diseases-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.subjectinfluenza vaccine-
dc.subjectrepeated vaccination-
dc.subjectimmune response-
dc.titleThe effect of influenza vaccination history on changes in hemagglutination inhibition titers after receipt of the 2015–2016 influenza vaccine in older adults in Hong Kong-
dc.typeArticle-
dc.identifier.emailNg, TWY: tiffnwy@HKUCC-COM.hku.hk-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailYau, EM: emyau@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailTam, YH: yhtam@hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityPerera, RAPM=rp02500-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityTam, YH=rp01881-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/infdis/jiz327-
dc.identifier.pmid31282541-
dc.identifier.scopuseid_2-s2.0-85076505573-
dc.identifier.hkuros315496-
dc.identifier.volume221-
dc.identifier.issue1-
dc.identifier.spage33-
dc.identifier.epage41-
dc.identifier.isiWOS:000521333400006-
dc.publisher.placeUnited States-
dc.identifier.issnl0022-1899-

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