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Article: Oncogenic pathway driven by p85β: upstream signals to activate p110

TitleOncogenic pathway driven by p85β: upstream signals to activate p110
Authors
RAO, LCheung, WTL
KeywordsPI3K
p85
AXL
autophagy
protein degradation
Issue Date2020
PublisherTaylor & Francis Inc.. The Journal's web site is located at http://www.tandfonline.com/kmco
Citation
Molecular & Cellular Oncology, 2020, v. 7 n. 5, p. article no. 1780900 How to Cite?
DOI: http://dx.doi.org/10.1080/23723556.2020.1780900
AbstractThe phosphatidylinositol 3-kinase (PI3K), which is composed of the p85 regulatory and p110 catalytic subunits, is known to be downstream of the receptor tyrosine kinase (RTK). Our recent findings revealed that p85β increases the protein level of AXL (an RTK) to activate p110, suggesting bidirectional regulation between PI3K and RTK.
Persistent Identifierhttp://hdl.handle.net/10722/288406
ISSN
2372-3548
PubMed Central ID
PMC7469557
ISI Accession Number ID
WOS:000549750800001

 

DC FieldValueLanguage
dc.contributor.authorRAO, L-
dc.contributor.authorCheung, WTL-
dc.date.accessioned2020-10-05T12:12:25Z-
dc.date.available2020-10-05T12:12:25Z-
dc.date.issued2020-
dc.identifier.citationMolecular & Cellular Oncology, 2020, v. 7 n. 5, p. article no. 1780900-
dc.identifier.issn2372-3548-
dc.identifier.urihttp://hdl.handle.net/10722/288406-
dc.description.abstractThe phosphatidylinositol 3-kinase (PI3K), which is composed of the p85 regulatory and p110 catalytic subunits, is known to be downstream of the receptor tyrosine kinase (RTK). Our recent findings revealed that p85β increases the protein level of AXL (an RTK) to activate p110, suggesting bidirectional regulation between PI3K and RTK.-
dc.languageeng-
dc.publisherTaylor & Francis Inc.. The Journal's web site is located at http://www.tandfonline.com/kmco-
dc.relation.ispartofMolecular & Cellular Oncology-
dc.rightsAOM/Preprint Before Accepted: his article has been accepted for publication in [JOURNAL TITLE], published by Taylor & Francis. AOM/Preprint After Accepted: This is an [original manuscript / preprint] of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/[Article DOI]. Accepted Manuscript (AM) i.e. Postprint This is an Accepted Manuscript of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/[Article DOI].-
dc.subjectPI3K-
dc.subjectp85-
dc.subjectAXL-
dc.subjectautophagy-
dc.subjectprotein degradation-
dc.titleOncogenic pathway driven by p85β: upstream signals to activate p110-
dc.typeArticle-
dc.identifier.emailCheung, WTL: lydiacwt@hku.hk-
dc.identifier.authorityCheung, WTL=rp02137-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1080/23723556.2020.1780900-
dc.identifier.pmid32944639-
dc.identifier.pmcidPMC7469557-
dc.identifier.scopuseid_2-s2.0-85087884370-
dc.identifier.hkuros315516-
dc.identifier.volume7-
dc.identifier.issue5-
dc.identifier.spagearticle no. 1780900-
dc.identifier.epagearticle no. 1780900-
dc.identifier.isiWOS:000549750800001-
dc.publisher.placeUnited States-

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