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Article: Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study
Title | Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study |
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Authors | |
Keywords | Cardiovascular disease depression genetics Mendelian randomization |
Issue Date | 2020 |
Publisher | Cambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM |
Citation | Psychological Medicine, 2020, Epub 2020-10-09 How to Cite? |
Abstract | Background:
Depression and cardiovascular disease (CVD) are associated with each other but their relationship remains unclear. We aim to determine whether genetic predisposition to depression are causally linked to CVD [including coronary artery disease (CAD), myocardial infarction (MI), stroke and atrial fibrillation (AF)].
Methods:
Using summary statistics from the largest genome-wide association studies (GWAS) or GWAS meta-analysis of depression (primary analysis: n = 500 199), broad depression (help-seeking behavior for problems with nerves, anxiety, tension or depression; secondary analysis: n = 322 580), CAD (n = 184 305), MI (n = 171 875), stroke (n = 446 696) and AF (n = 1 030 836), genetic correlation was tested between two depression phenotypes and CVD [MI, stroke and AF (not CAD as its correlation was previously confirmed)]. Causality was inferred between correlated traits by Mendelian Randomization analyses.
Results:
Both depression phenotypes were genetically correlated with MI (depression: rG = 0.169; p = 9.03 × 10−9; broad depression: rG = 0.123; p = 1 × 10−4) and AF (depression: rG = 0.112; p = 7.80 × 10−6; broad depression: rG = 0.126; p = 3.62 × 10−6). Genetically doubling the odds of depression was causally associated with increased risk of CAD (OR = 1.099; 95% CI 1.031–1.170; p = 0.004) and MI (OR = 1.146; 95% CI 1.070–1.228; p = 1.05 × 10−4). Adjustment for blood lipid levels/smoking status attenuated the causality between depression and CAD/MI. Null causal association was observed for CVD on depression. A similar pattern of results was observed in the secondary analysis for broad depression.
Conclusions:
Genetic predisposition to depression may have positive causal roles on CAD/MI. Genetic susceptibility to self-awareness of mood problems may be a strong causal risk factor of CAD/MI. Blood lipid levels and smoking may potentially mediate the causal pathway. Prevention and early diagnosis of depression are important in the management of CAD/MI. |
Persistent Identifier | http://hdl.handle.net/10722/289274 |
ISSN | 2023 Impact Factor: 5.9 2023 SCImago Journal Rankings: 2.768 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, HY | - |
dc.contributor.author | Cheung, CL | - |
dc.contributor.author | Chung, AKK | - |
dc.contributor.author | Cheung, BMY | - |
dc.contributor.author | Wong, ICK | - |
dc.contributor.author | Fok, MLY | - |
dc.contributor.author | Au, PCM | - |
dc.contributor.author | Sham, PC | - |
dc.date.accessioned | 2020-10-22T08:10:20Z | - |
dc.date.available | 2020-10-22T08:10:20Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Psychological Medicine, 2020, Epub 2020-10-09 | - |
dc.identifier.issn | 0033-2917 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289274 | - |
dc.description.abstract | Background: Depression and cardiovascular disease (CVD) are associated with each other but their relationship remains unclear. We aim to determine whether genetic predisposition to depression are causally linked to CVD [including coronary artery disease (CAD), myocardial infarction (MI), stroke and atrial fibrillation (AF)]. Methods: Using summary statistics from the largest genome-wide association studies (GWAS) or GWAS meta-analysis of depression (primary analysis: n = 500 199), broad depression (help-seeking behavior for problems with nerves, anxiety, tension or depression; secondary analysis: n = 322 580), CAD (n = 184 305), MI (n = 171 875), stroke (n = 446 696) and AF (n = 1 030 836), genetic correlation was tested between two depression phenotypes and CVD [MI, stroke and AF (not CAD as its correlation was previously confirmed)]. Causality was inferred between correlated traits by Mendelian Randomization analyses. Results: Both depression phenotypes were genetically correlated with MI (depression: rG = 0.169; p = 9.03 × 10−9; broad depression: rG = 0.123; p = 1 × 10−4) and AF (depression: rG = 0.112; p = 7.80 × 10−6; broad depression: rG = 0.126; p = 3.62 × 10−6). Genetically doubling the odds of depression was causally associated with increased risk of CAD (OR = 1.099; 95% CI 1.031–1.170; p = 0.004) and MI (OR = 1.146; 95% CI 1.070–1.228; p = 1.05 × 10−4). Adjustment for blood lipid levels/smoking status attenuated the causality between depression and CAD/MI. Null causal association was observed for CVD on depression. A similar pattern of results was observed in the secondary analysis for broad depression. Conclusions: Genetic predisposition to depression may have positive causal roles on CAD/MI. Genetic susceptibility to self-awareness of mood problems may be a strong causal risk factor of CAD/MI. Blood lipid levels and smoking may potentially mediate the causal pathway. Prevention and early diagnosis of depression are important in the management of CAD/MI. | - |
dc.language | eng | - |
dc.publisher | Cambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM | - |
dc.relation.ispartof | Psychological Medicine | - |
dc.rights | Psychological Medicine. Copyright © Cambridge University Press. | - |
dc.rights | This article has been published in a revised form in [Journal] [http://doi.org/XXX]. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder. | - |
dc.subject | Cardiovascular disease | - |
dc.subject | depression | - |
dc.subject | genetics | - |
dc.subject | Mendelian randomization | - |
dc.title | Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study | - |
dc.type | Article | - |
dc.identifier.email | Li, HY: gloriali@hku.hk | - |
dc.identifier.email | Cheung, CL: lung1212@hku.hk | - |
dc.identifier.email | Chung, AKK: chungkka@hku.hk | - |
dc.identifier.email | Cheung, BMY: mycheung@hkucc.hku.hk | - |
dc.identifier.email | Wong, ICK: wongick@hku.hk | - |
dc.identifier.email | Sham, PC: pcsham@hku.hk | - |
dc.identifier.authority | Cheung, CL=rp01749 | - |
dc.identifier.authority | Chung, AKK=rp02341 | - |
dc.identifier.authority | Cheung, BMY=rp01321 | - |
dc.identifier.authority | Wong, ICK=rp01480 | - |
dc.identifier.authority | Sham, PC=rp00459 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1017/S0033291720003566 | - |
dc.identifier.pmid | 33032663 | - |
dc.identifier.scopus | eid_2-s2.0-85093535747 | - |
dc.identifier.hkuros | 316678 | - |
dc.identifier.volume | Epub 2020-10-09 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 12 | - |
dc.identifier.isi | WOS:000823927100018 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0033-2917 | - |