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Article: Cell‐Inspired All‐Aqueous Microfluidics: From Intracellular Liquid–Liquid Phase Separation toward Advanced Biomaterials

TitleCell‐Inspired All‐Aqueous Microfluidics: From Intracellular Liquid–Liquid Phase Separation toward Advanced Biomaterials
Authors
Keywordsadvanced biomaterials
all‐aqueous microfluidics
cell‐inspiration
intracellular organelles
liquid–liquid phase separation
Issue Date2020
PublisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844
Citation
Advanced Science, 2020, v. 7 n. 7, p. article no. 1903359 How to Cite?
AbstractLiving cells have evolved over billions of years to develop structural and functional complexity with numerous intracellular compartments that are formed due to liquid–liquid phase separation (LLPS). Discovery of the amazing and vital roles of cells in life has sparked tremendous efforts to investigate and replicate the intracellular LLPS. Among them, all‐aqueous emulsions are a minimalistic liquid model that recapitulates the structural and functional features of membraneless organelles and protocells. Here, an emerging all‐aqueous microfluidic technology derived from micrometer‐scaled manipulation of LLPS is presented; the technology enables the state‐of‐art design of advanced biomaterials with exquisite structural proficiency and diversified biological functions. Moreover, a variety of emerging biomedical applications, including encapsulation and delivery of bioactive gradients, fabrication of artificial membraneless organelles, as well as printing and assembly of predesigned cell patterns and living tissues, are inspired by their cellular counterparts. Finally, the challenges and perspectives for further advancing the cell‐inspired all‐aqueous microfluidics toward a more powerful and versatile platform are discussed, particularly regarding new opportunities in multidisciplinary fundamental research and biomedical applications.
Persistent Identifierhttp://hdl.handle.net/10722/289759
ISSN
2018 Impact Factor: 15.804
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorMa, Q-
dc.contributor.authorSong, Y-
dc.contributor.authorSun, W-
dc.contributor.authorCao, J-
dc.contributor.authorYuan, H-
dc.contributor.authorWang, X-
dc.contributor.authorSun, Y-
dc.contributor.authorShum, HC-
dc.date.accessioned2020-10-22T08:17:04Z-
dc.date.available2020-10-22T08:17:04Z-
dc.date.issued2020-
dc.identifier.citationAdvanced Science, 2020, v. 7 n. 7, p. article no. 1903359-
dc.identifier.issn2198-3844-
dc.identifier.urihttp://hdl.handle.net/10722/289759-
dc.description.abstractLiving cells have evolved over billions of years to develop structural and functional complexity with numerous intracellular compartments that are formed due to liquid–liquid phase separation (LLPS). Discovery of the amazing and vital roles of cells in life has sparked tremendous efforts to investigate and replicate the intracellular LLPS. Among them, all‐aqueous emulsions are a minimalistic liquid model that recapitulates the structural and functional features of membraneless organelles and protocells. Here, an emerging all‐aqueous microfluidic technology derived from micrometer‐scaled manipulation of LLPS is presented; the technology enables the state‐of‐art design of advanced biomaterials with exquisite structural proficiency and diversified biological functions. Moreover, a variety of emerging biomedical applications, including encapsulation and delivery of bioactive gradients, fabrication of artificial membraneless organelles, as well as printing and assembly of predesigned cell patterns and living tissues, are inspired by their cellular counterparts. Finally, the challenges and perspectives for further advancing the cell‐inspired all‐aqueous microfluidics toward a more powerful and versatile platform are discussed, particularly regarding new opportunities in multidisciplinary fundamental research and biomedical applications.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844-
dc.relation.ispartofAdvanced Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectadvanced biomaterials-
dc.subjectall‐aqueous microfluidics-
dc.subjectcell‐inspiration-
dc.subjectintracellular organelles-
dc.subjectliquid–liquid phase separation-
dc.titleCell‐Inspired All‐Aqueous Microfluidics: From Intracellular Liquid–Liquid Phase Separation toward Advanced Biomaterials-
dc.typeArticle-
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.authorityShum, HC=rp01439-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/advs.201903359-
dc.identifier.pmid32274317-
dc.identifier.pmcidPMC7141073-
dc.identifier.scopuseid_2-s2.0-85079376088-
dc.identifier.hkuros317462-
dc.identifier.volume7-
dc.identifier.issue7-
dc.identifier.spagearticle no. 1903359-
dc.identifier.epagearticle no. 1903359-
dc.publisher.placeGermany-

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