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Article: Targeting PIN1 as a Therapeutic Approach for Hepatocellular Carcinoma
Title | Targeting PIN1 as a Therapeutic Approach for Hepatocellular Carcinoma |
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Authors | |
Keywords | PIN1 phosphorylation hepatocellular carcinoma inhibitor hepatocarcinogenes |
Issue Date | 2020 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at https://www.frontiersin.org/journals/cell-and-developmental-biology |
Citation | Frontiers in Cell and Developmental Biology, 2020, v. 7, p. article no. 369 How to Cite? |
Abstract | PIN1 is a peptidyl-prolyl cis/trans isomerase that specifically binds and catalyzes the cis/trans isomerization of the phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif of its interacting proteins. Through this phosphorylation-dependent prolyl isomerization, PIN1 is involved in the regulation of various important cellular processes including cell cycle progression, cell proliferation, apoptosis and microRNAs biogenesis; hence its dysregulation contributes to malignant transformation. PIN1 is highly expressed in hepatocellular carcinoma (HCC). By fine-tuning the functions of its interacting proteins such as cyclin D1, x-protein of hepatitis B virus and exportin 5, PIN1 plays an important role in hepatocarcinogenesis. Growing evidence supports that targeting PIN1 is a potential therapeutic approach for HCC by inhibiting cell proliferation, inducing cellular apoptosis, and restoring microRNAs biogenesis. Novel formulation of PIN1 inhibitors that increases in vivo bioavailability of PIN1 inhibitors represents a promising future direction for the therapeutic strategy of HCC treatment. In this review, the mechanisms underlying PIN1 over-expression in HCC are explored. Furthermore, we also discuss the roles of PIN1 in HCC tumorigenesis and metastasis through its interaction with various phosphoproteins. Finally, recent progress in the therapeutic options targeting PIN1 for HCC treatment is examined and summarized. |
Persistent Identifier | http://hdl.handle.net/10722/289778 |
ISSN | 2023 Impact Factor: 4.6 2023 SCImago Journal Rankings: 1.576 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cheng, CW | - |
dc.contributor.author | Tse, E | - |
dc.date.accessioned | 2020-10-22T08:17:20Z | - |
dc.date.available | 2020-10-22T08:17:20Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frontiers in Cell and Developmental Biology, 2020, v. 7, p. article no. 369 | - |
dc.identifier.issn | 2296-634X | - |
dc.identifier.uri | http://hdl.handle.net/10722/289778 | - |
dc.description.abstract | PIN1 is a peptidyl-prolyl cis/trans isomerase that specifically binds and catalyzes the cis/trans isomerization of the phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif of its interacting proteins. Through this phosphorylation-dependent prolyl isomerization, PIN1 is involved in the regulation of various important cellular processes including cell cycle progression, cell proliferation, apoptosis and microRNAs biogenesis; hence its dysregulation contributes to malignant transformation. PIN1 is highly expressed in hepatocellular carcinoma (HCC). By fine-tuning the functions of its interacting proteins such as cyclin D1, x-protein of hepatitis B virus and exportin 5, PIN1 plays an important role in hepatocarcinogenesis. Growing evidence supports that targeting PIN1 is a potential therapeutic approach for HCC by inhibiting cell proliferation, inducing cellular apoptosis, and restoring microRNAs biogenesis. Novel formulation of PIN1 inhibitors that increases in vivo bioavailability of PIN1 inhibitors represents a promising future direction for the therapeutic strategy of HCC treatment. In this review, the mechanisms underlying PIN1 over-expression in HCC are explored. Furthermore, we also discuss the roles of PIN1 in HCC tumorigenesis and metastasis through its interaction with various phosphoproteins. Finally, recent progress in the therapeutic options targeting PIN1 for HCC treatment is examined and summarized. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at https://www.frontiersin.org/journals/cell-and-developmental-biology | - |
dc.relation.ispartof | Frontiers in Cell and Developmental Biology | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | PIN1 | - |
dc.subject | phosphorylation | - |
dc.subject | hepatocellular carcinoma | - |
dc.subject | inhibitor | - |
dc.subject | hepatocarcinogenes | - |
dc.title | Targeting PIN1 as a Therapeutic Approach for Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Cheng, CW: timwai@hku.hk | - |
dc.identifier.email | Tse, E: ewctse@hku.hk | - |
dc.identifier.authority | Tse, E=rp00471 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fcell.2019.00369 | - |
dc.identifier.pmid | 32010690 | - |
dc.identifier.pmcid | PMC6974617 | - |
dc.identifier.scopus | eid_2-s2.0-85078759486 | - |
dc.identifier.hkuros | 317068 | - |
dc.identifier.volume | 7 | - |
dc.identifier.spage | article no. 369 | - |
dc.identifier.epage | article no. 369 | - |
dc.identifier.isi | WOS:000556735800001 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 2296-634X | - |